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  • Tissue culture products - Biodetection Systems
    Expertise Facilities Projects Contract research News Downloads News Events Publications Downloads Contact Contact information Directions International partners Login Print Bioassays Reference materials Standards Tissue culture products Extraction clean up products Tissue culture products We offer several products used for culturing the CALUX cells and performing of the assays such as trypsine lysis mix measuring solutions FCS and stripped FCS Most products we offer are tested to ensure correct functioning in

    Original URL path: http://www.biodetectionsystems.com/products/tissue-culture-products.html (2016-02-10)
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  • Extraction clean-up products - Biodetection Systems
    Contact Contact information Directions International partners Login Print Bioassays Reference materials Standards Tissue culture products Extraction clean up products Extraction clean up products BDS offers different products that have been optimized for the use together with our bioassays Our columns that are extensively used in our dioxin analyses are tailor made to ensure a fast running profile easy cleaning ability and are robust in their use The columns can be

    Original URL path: http://www.biodetectionsystems.com/products/extraction-clean-up-products.html (2016-02-10)
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  • Applications - Biodetection Systems
    Water quality Innovations Expertise Facilities Projects Contract research News Downloads News Events Publications Downloads Contact Contact information Directions International partners Login Print Food Feed Product Safety Human health epidemiology Chemicals pharmaceuticals Complex mixtures Environment Water quality Numerous applications Our assays and techniques are suitable for numerous applications Our technology is used for standard service analyses as well as in research projects related to e g food feed and environmental quality

    Original URL path: http://www.biodetectionsystems.com/applications.html (2016-02-10)
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  • Food / Feed - Biodetection Systems
    Product Safety Human health epidemiology Chemicals pharmaceuticals Complex mixtures Environment Water quality Food Feed BDS offers analyses that specifically target dioxins dioxin like PCBs nondioxin like PCBs and PAHs In addition to the screenings for adverse compounds CALUX assays are used in screenings for potentially beneficial functional traits of food products With our DNA based authentication service we also offer the possibility of tracing the origin of food constituents such animal species included in meat containing products Safety testing The presence of dioxins and PCBs in food and feed is subjected to international regulations The EU has laid down general requirements for the determination of dioxins and dioxin like PCBs in food and feed using cell based bioassays The DR CALUX bioassay fully complies with these stringent requirements and is ISO 17025 accredited registration number RvA L401 For samples that are suspected based on the DR CALUX results we offer confirmative analysis by GC HRMS Detection of nondioxin like PCBs is performed by chemical analysis GC ECD ISO 17025 accredited Functionality testing In addition to specific unwanted toxicants and constituents that determine the nutritional value food products may contain compounds that could elicit a range of health promoting or adverse

    Original URL path: http://www.biodetectionsystems.com/applications/food-feed.html (2016-02-10)
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  • Product Safety - Biodetection Systems
    Human health epidemiology Chemicals pharmaceuticals Complex mixtures Environment Water quality Product Safety Our health may not only be affected by chemical compounds that are food or environment based but also by compounds that migrate from consumer products and packaging materials Examples of consumer product related chemicals that are under suspicion for their potential health effects are certain plasticizers and fire retardants CALUX assays can be used to control and monitor

    Original URL path: http://www.biodetectionsystems.com/applications/product-safety.html (2016-02-10)
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  • Human health / epidemiology - Biodetection Systems
    mixtures Environment Water quality Human health epidemiology Human health can be affected by exposure to a wide variety of chemicals Many processes that play a role in the onset of adverse health effects such as immunotoxicity endocrine disruption obesity and metabolic diseases carcinogenesis and reproductive toxicity can be assessed with CALUX reporter assays The sensitivity and high throughput compatibility of these assays makes them suitable both for mechanistic studies as well as screenings of large sample panels In many cases epidemiological studies and monitoring of human health effects are hampered by the limited amount of available sample material e g tissue blood In addition many analytical techniques are costly and time consuming to perform CALUX bioassays require small amount of material e g 1 ml human plasma for DR CALUX Especially in case of larger sample series CALUX analyses can be performed in a time and cost efficient manner due to the standardized high throughput compatible assay protocols Another important benefit of using CALUX assays is that they often give mechanistic insight in health effects that may otherwise only be correlated to a certain exposure from a statistical point of view Typical bioassays used for human monitoring and epidemiological studies

    Original URL path: http://www.biodetectionsystems.com/applications/human-health-epidemiology.html (2016-02-10)
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  • Chemicals & pharmaceuticals - Biodetection Systems
    information Directions International partners Login Print Food Feed Product Safety Human health epidemiology Chemicals pharmaceuticals Complex mixtures Environment Water quality Chemicals pharmaceuticals Correct safety evaluation of chemicals and pharmaceuticals is essential to protect consumers For industries realistic safety evaluation is of equal importance The use of experimental animals in safety evaluation is under pressure not only because of obvious ethical reasons but also because these tests are expensive time consuming low in throughput and often give unsatisfactory predictions of human toxicity Modern mechanistic bioassays provide insight in the modes of action of toxicants and can be used as alternative methods to assess chemical safety particularly when coupled to so called adverse outcome pathways AOP We have developed a wide range of such human cell based assays and we have automated them for the use in high throughput panels to assess safety of chemicals and pharmaceuticals These methods are particularly suited for use in integrated testing and read across procedures Other major applications include screening and bioactivity profiling to select new candidate drugs and chemicals with promising profiles with respect to safety Our latest developments focus on activity screens directed to beneficial effects including bioactivity profiling of herbal drugs and functional

    Original URL path: http://www.biodetectionsystems.com/applications/chemicals-pharmaceuticals.html (2016-02-10)
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  • Complex mixtures - Biodetection Systems
    Publications Downloads Contact Contact information Directions International partners Login Print Food Feed Product Safety Human health epidemiology Chemicals pharmaceuticals Complex mixtures Environment Water quality Complex mixtures Biological effects by mixtures are typically hard to predict from chemical analytical data on the individual constituents which usually only cover part of the compounds actually present This can be circumvented by direct measurement of sum effects from the bioactive components in the mixture using CALUX reporter assays While most compounds are only tested if at all for their health effects in their pure form we are mostly exposed to complex mixtures of compounds Predicting health effects of mixtures is typically complicated for the interactions that may occur as well as the lack of information on individual components Effect based measurements using CALUX assays offer two important features for providing information on the effects of mixtures CALUX assays focus on effects instead of compounds This avoids bias towards targeted compounds CALUX assays directly measure the combined effects by the total mixture that is analyzed Results are therefore independent of prior toxicological knowledge on the individual constituents of a mixture and their mutual effects If desired a combination of chemical analytical and biology based techniques

    Original URL path: http://www.biodetectionsystems.com/applications/complex-mixtures.html (2016-02-10)
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