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  • Environment - Biodetection Systems
    dioxins PCBs and PAHs In addition various assays are available for the screening of environmental samples on effects they could have on processes relating to adverse health effects such as endocrine disruption carcinogenicity mutagenicity and developmental toxicity CALUX reporter assays are suitable for a wide range of applications regarding environmental safety assessment Our assays have been used for identifying pollution hotspots profiling health hazard related potencies on polluted sites effect

    Original URL path: http://www.biodetectionsystems.com/applications/environment.html (2016-02-10)
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  • Water quality - Biodetection Systems
    Complex mixtures Environment Water quality Water quality Being one of the key necessities of life water should be submitted to a thorough quality control Targeted chemical analysis of priority compounds can give an impression of the chemical quality but may not cover the entire load of pollutants that evoke biological effects CALUX assays are successfully applied in the identification of water samples that are polluted with biologically active toxicants even at low levels and address the complexity associated with the compound mixtures Current water quality monitoring practices mainly rely on targeted chemical analysis of selected set of compounds e g priority compounds This compound oriented approach however does not cover the entire load of pollution and may overlook the presence of biologically active chemicals Effect oriented testing approaches can overcome this limitation by measuring the effect of the total mixture of compounds that are present in a sample The CALUX assay panel is particularly suitable for this purpose since it detects a number of key effects in relation to water quality BDS provides routine services and participates various national and international projects in order to further implement a minimal panel of CALUX assays from a broad range of available assays

    Original URL path: http://www.biodetectionsystems.com/applications/water-quality.html (2016-02-10)
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  • Innovations - Biodetection Systems
    economy increasingly rely on bioanalytical tools to assess safety and beneficial activities in extremely complex often recycled mixtures of natural and synthetic chemicals BDS is a front end player in this area Our laboratories include fully equipped Innovation and Development departments with ample experience in developing new bioanalytical tools including all current CALUX assays and their various applications Recently the CALUX methods have been transformed from the classical manual format to high throughput formats using robotics This also allowed miniaturization to 384 wells format increasing both throughput and accuracy Furthermore in this miniaturised set up only a fraction of the original sample volume is required which is especially relevant when only small sample volumes are available such as in clinical or epidemiological studies Comprehensive panels of bioassays have been developed for safety and activity profiling for various applications Current research focuses on further expansion of the range of bioanalytical tools and their applications Those include animal alternatives to do activity screens and safety assessments DNA barcoding methods e g for food identification and tool development for rapid data interpretation and extrapolation including assessment of metabolism and pharmacokinetics In addition cost reduction simplification kit based technologies and on line technologies are

    Original URL path: http://www.biodetectionsystems.com/innovations.html (2016-02-10)
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  • Expertise - Biodetection Systems
    employs highly trained personnel with a strong academic and commercial background In addition the BDS team does not operate in isolation but in an extensive network of international collaborations This allows handling of sensitive and complex analytical problems interpretation of the data and consultancy We offer our technologies and services world wide through a network of laboratories and agents and we thereby have access to a wide range of service

    Original URL path: http://www.biodetectionsystems.com/innovations/expertise.html (2016-02-10)
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  • Facilities - Biodetection Systems
    Downloads Contact Contact information Directions International partners Login Print Expertise Facilities Projects Contract research Facilities Our staff and facilities comprise knowledge experience and equipment for performing projects related to effect based testing and the development and validation of new experimental tools and approaches We use this infrastructure for improving and expanding our own portfolio but we also offer contract analysis services and contract research BDS is located at the Amsterdam Science Park ASP in the Netherlands The Amsterdam Science Park hosts one of the largest concentrations of beta sciences in Europe Among the residents of the ASP are the University of Amsterdam Faculty of Science Amsterdam University College other research institutes and some 120 companies from start ups to multinationals all working in the fields of IT Life Sciences advanced technology and sustainability We are operating internationally and can offer contract service analyses contract research and licencing of our CALUX biotechnology BDS has a state of the art and fully equipped laboratory with a wide range of methods high level of knowledge and expertise Our facilities are equipped for a o Cell culturing Extraction of a wide variety of matrices using e g ASE Post extraction clean up e g

    Original URL path: http://www.biodetectionsystems.com/innovations/facilities.html (2016-02-10)
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  • Projects - Biodetection Systems
    of our technologies to different stakeholders In addition to active participation in these projects our scientific staff often plays a coordinating role An overview of some of the larger research projects we participated in is presented below 2012 DEMEAU Demonstration of promising technologies to address emerging pollutants in water and waste water EU FP7 2012 2010 BE Basic Bio based Ecologically Balanced Sustainable Industrial Chemistry member of coordination team and partner 2010 ECOLINC Ecogenomics Innovation Centre NGI coordinator 2010 ZonMw Dierproeven Begrensd Validation and implementation of rapid and cost effective human in vitro screening assays to predict genotoxicity and carcinogenicity of chemicals and pharmaceuticals 2010 RAAK PRO Alternatieve testbatterij voor veiligheid en werking van natuurlijke stoffen 2010 ChemScreen Chemical substance in vitro in silico evaluation and exclusion system to predict human and ecotoxicological effects EU FP7 coordinator 2010 Plantlibra PLANT food supplements Levels of Intake Benefit and Risk Assessment 2010 2009 Metaexplore Metagenomics for bioexploration tools and application EU FP7 2009 2008 Netherlands Toxicogenomics Centre NTC 2008 Top Institute Pharma Towards novel translational safety biomarkers for adverse drug toxicity 2008 Genes4water program G4W A genomics approach to develop an effect based water quality assessment framework 2008 Food and Nutrition Delta Assay toolbox for health effects of functional foods coordinator 2008 2006 NewGeneris Newborns and Genotoxic exposure risks Development and application of biomarkers of dietary exposure to genotoxic chemicals and biomarkers of precarcinogenic and immunomodulatory effects using mother child birth cohorts and biobanks EU FP6 IP 2006 TECHNEAU Technology enabled universal access to safe water EU FP6 IP 2006 2005 Mechanism based toxicogenomics to develop an in vitro high throughput test for human cancer hazard assessment of non genotoxic chemicals 2005 FACEiT Fast advanced cellular and ecosystems information technologies EU FP6 STREP 2005 ZonMw Development of in vitro test strategies for

    Original URL path: http://www.biodetectionsystems.com/innovations/projects.html (2016-02-10)
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  • Contract research - Biodetection Systems
    Projects Contract research Contract research The combined expertise of our personnel and our laboratories that are equipped for a wide range of techniques allow for the successful execution of contract research projects for our customers This can range from routine measurements of samples in our service department to the setup of new bio analytical methods to complex R D projects guided by our academically trained staff Our ample experience in

    Original URL path: http://www.biodetectionsystems.com/innovations/contract-research.html (2016-02-10)
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  • News & Downloads - Biodetection Systems
    Standards Tissue culture products Extraction clean up products Applications Food Feed Product Safety Human health epidemiology Chemicals pharmaceuticals Complex mixtures Environment Water quality Innovations Expertise Facilities Projects Contract research News Downloads News Events Publications Downloads Contact Contact information Directions International

    Original URL path: http://www.biodetectionsystems.com/news-downloads.html (2016-02-10)
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