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  • Identification of S100A8 and S100A9 as negative regulators for lymph node metastasis of gastric adenocarcinoma.
    of expression of S100A8 and S100A9 in gastric adenocarcinoma using a tissue microarray of 218 gastric adenocarcinoma specimens Cell invasion and migration assay were performed to confirm functional role of S100A8 and S100A9 using small hairpin RNA lentivirus We identified 8 up regulated and 5 down regulated proteins in gastric cancer tissues compared to matched normal mucosa Of these expression of S100A8 and S100A9 occurred mainly in stromal cells and inflammatory cells between tumor cells Correlation was observed between small lesion size decreased depth of invasion a tendency to absence of lymphovascular tumor emboli a decrease in perineural invasion and lymph node metastasis and expression of stromal S100A8 In addition increased expression of stromal S100A9 in gastric adenocarcinoma was associated with small lesion size and a decrease in lymph node metastasis Functional analysis confirmed that down regulation of S100A8 and S100A9 by small hairpin RNA lentivirus induced an increase of migration and invasion in gastric cancer cell lines Taken together these findings suggest that S100A8 and S100A9 are negative regulators of lymph node metastasis of gastric adenocarcinoma and can be used as biomarkers for prediction of lymph node metastasis in gastric adenocarcinoma Authors J H Choi N R Shin H J Moon C H Kwon G H Kim G A Song T Y Jeon D H Kim D H Kim D Y Park Related Documents 21877993 Carcinoma of the breast with choriocarcinomatous features 15160993 Molecular pathogenesis and prevention of prostate cancer 18958543 Polymorphisms of matrix metalloproteinase 7 and chymase are associated with susceptibil Publication Detail Type Journal Article Journal Detail Title Histology and histopathology Volume 27 ISSN 1699 5848 ISO Abbreviation Histol Histopathol Publication Date 2012 Nov Date Detail Created Date 2012 09 28 Completed Date Revised Date Medline Journal Info Nlm Unique ID 8609357 Medline TA Histol Histopathol Country
    http://www.biomedsearch.com/nih/Identification-S100A8-S100A9-as-negative/23018243.html (2012-10-12)

  • Regulation of neuronal and endothelial nitric oxide synthase by anabolic-androgenic steroid in skeletal muscles.
    treadmill running one hour day 5 days week were administered mesterolone Sed M and Ex M respectively or gum arabic vehicle Ex C during the last three weeks three alternate days per week Consistently The TA showed the strongest labeling and the SOL the weakest with NOS III predominating over NOS I Mesterolone administered to sedentary mice Sed C x Sed M significantly upregulated NOS I in TA and SOL and NOS III in all three muscles Mesterolone administered to exercised mice Ex C x Ex M upregulated NOS I in all three muscles and NOS III in TA and SOL The exercise to mesterolone treated mice Sed M x Ex M produced a strong increase in NOS I expression in GAS in contrast it antagonized the mesterolone induced upregulation of NOS I in TA muscle and NOS III in SOL and GAS The data show nitric oxide NO as a potential signaling mediator of AAS effects in skeletal muscle and that NOS I and NOS III upregulations were muscle phenotype specific These may be regarded as an indication of the complex NOS NO signaling mechanism related with AAS effects vs metabolic physiological muscle characteristics Authors K Fontana T Rocha M A da Cruz Höfling Related Documents 9256004 Estimation of loads and stresses in abdominal muscles during slow lifts 19065984 Surgical management for large hypertropia and exotropia after disinsertion of inferior 12973004 Localization of tc 99m mdp in the rectus abdominis muscle without associated symptoms 6964654 Importance of tenon s capsule in squint surgery 7519344 Response of colonic smooth muscle from newborn and adult rabbits to electrical field st 3085954 The muscle pattern of a segment of drosophila may be determined by neurons and not by c Publication Detail Type Journal Article Journal Detail Title Histology and histopathology Volume 27
    http://www.biomedsearch.com/nih/Regulation-neuronal-endothelial-nitric-oxide/23018244.html (2012-10-12)

  • Distribution of exogenous metallothionein following intraperitoneal and intramuscular injection of metallothionein-deficient mice.
    deficient mice by immunohistochemistry of tissue samples and western blotting of urine samples MT IIA was detected within epithelial cells of the kidney cortical and medullary tubules within 1 hour of either intramuscular or intraperitoneal injection Additionally MT IIA was detected within the urine at 1 hour after injection indicating rapid absorbance into the circulation and filtration through the kidney glomerulus A portion of the intramuscularly injected MT IIA remained within the muscle for at least 24 hours after injection No MT IIA was observed within the liver or the brain after either a single injection or a series of MT IIA injections These results are consistent with earlier reports that exogenously administered MT IIA does not cross the intact blood brain barrier although a receptor for MT I II megalin is present in the choroid plexus We postulate that due to losses through the urine circulating MT IIA levels drop rapidly after injection and do not permit transport across the choroid plexus Peptide analogues of MT I II with similar neuroactive properties emtins may be more suited for CNS delivery Authors K E Lewis R S Chung A K West M I Chuah Related Documents 2153805 17 beta estradiol is the most active component of the conjugated estrogen mixture activ 11394645 Endothelin like immunoreactivity in lactotrophs gonadotrophs and somatotrophs of rat 19463685 Oestrogen and progestins differently prevent glutamate toxicity in cortical neurons dep 7407565 Estrogen metabolism in neural tissues of six day old rats 21396095 Effects of a selectively bred novelty seeking phenotype on the motivation to take cocai 22943605 Effect of dha epa on oxidative stress and apoptosis induced by ischemia reperfusion in Publication Detail Type Journal Article Journal Detail Title Histology and histopathology Volume 27 ISSN 1699 5848 ISO Abbreviation Histol Histopathol Publication Date 2012 Nov Date
    http://www.biomedsearch.com/nih/Distribution-exogenous-metallothionein-following-intraperitoneal/23018245.html (2012-10-12)

  • Experimental diabetes modulates collagen remodelling of joints in rats.
    types I III and V collagen in ligaments and synovial tissues and types II and XI collagen in cartilage Results Higher blood glucose levels and plasma anti carboxymethyllysine were observed in DG rats when compared to those in CG rats The final weight was significantly lower in the DG rats than in the CG rats Histomorphometric evaluation depicted a small quantity of collagen fibers in ligaments and articular cartilage in DG rats as well as increased collagen in synovial tissue There was a decrease in cartilage proteoglycans in DG rats when compared with CG rats Immunofluorescence staining revealed an increase of collagen III and V in ligaments collagen XI in cartilage and collagen I in synovial tissue of DG rats compared with CG rats Conclusion The ligaments cartilage and synovia are highly affected following STZ induced diabetes in rats due the remodeling of collagen types in these tissues This process may promote the degradation of the extracellular matrix thus compromising joint function Our data may help to better understand the pathogenesis of joint involvement related to diabetes Authors S A Atayde N H Yoshinari D P Nascimento S Catanozi P C Andrade A P P Velosa E R Parra M Passarelli E R Nakandakare V L Capelozzi W R Teodoro Related Documents 11247536 Effect of urea and pantothenol on the permeation of progesterone through excised rat sk 19280376 Effect of chemical enhancers on percutaneous absorption of daphnetin in isopropyl myri 1449476 Substrate preference of metalloproteinases secreted by ts 110 moloney murine sarcoma vi 12070496 The effect of fibrin clot on healing rat supraspinatus tendon defects 7271366 Effect of gossypol on boar spermatozoa in vitro 3583156 Lack of hepatic microsomal metabolism of deoxynivalenol and its metabolite dom 1 Publication Detail Type Journal Article Journal Detail Title Histology and histopathology Volume 27
    http://www.biomedsearch.com/nih/Experimental-diabetes-modulates-collagen-remodelling/23018246.html (2012-10-12)

  • Clinicopathologic features of molecular subtypes of triple negative breast cancer based on immunohistochemical markers.
    apocrine AR positive and or GGT1 positive claudin low claudin 3 claudin 4 claudin 7 negative and or E cadherin negative mixed tumors belonging to two or more subtypes and null tumors not matching any other subtypes The TNBC specimens of 122 patients included 27 basal like 22 1 28 claudin low 23 0 12 molecular apocrine 9 8 23 mixed 18 9 and 32 null 26 2 subtype tumors The molecular apocrine subtype showed the highest percentage of apocrine differentiation and the lowest Ki 67 labeling index p 0 001 and p 0 040 respectively In univariate analysis tumor cell discohesiveness was related with shorter disease free survival DFS and overall survival OS p 0 005 and 0 002 respectively In multivariate analysis tumor cell discohesiveness was related with shorter OS and CK5 6 positivity p 0 018 and claudin 7 positivity p 0 019 was related with shorter DFS In conclusion using immunohistochemical staining for CK5 6 EGFR claudin 3 claudin 4 claudin 7 E cadherin AR and GGT1 we categorized TNBC into a basal like subtype a claudin low subtype a molecular apocrine subtype a mixed subtype showing characteristics of two different subtypes and a null subtype not belonging to any of the subtypes identified Authors J Choi W H Jung J S Koo Related Documents 22943017 Immunohistochemical features of the gastrointestinal tract tumors 8657737 Benzophenothiazine and benzoporphyrin derivative combination phototherapy effectively e 2034787 Oxygen consumption and diffusion effects in photodynamic therapy 10486597 Improving diagnostic staging laparoscopy using intraperitoneal lavage of delta aminolev 9694107 Nonteratomatous germ cell tumors in children 18769117 Hdac3 impacts multiple oncogenic pathways in colon cancer cells with effects on wnt and Publication Detail Type Journal Article Journal Detail Title Histology and histopathology Volume 27 ISSN 1699 5848 ISO Abbreviation Histol Histopathol Publication Date
    http://www.biomedsearch.com/nih/Clinicopathologic-features-molecular-subtypes-triple/23018247.html (2012-10-12)

  • Expression of matricellular proteins in human uterine leiomyomas and normal myometrium.
    human uterine leiomyomas and normal myometrium Immunostaining was performed on 33 pairs of paraffin fixed sections and 9 cell lines derived from uterine leiomyomas and normal myometrium Fifteen 45 5 leiomyomas investigated were positive for TNC whereas all normal myometrial samples were immunonegative χ² 19 41 p 0 001 Immunostaining for TSP 1 was observed in 20 60 6 uterine fibroids and in 12 36 4 control samples χ² 3 88 p 0 05 The expression of SPARC osteonectin protein was more frequently found in leiomyomas than in normal myometrium but this difference was not significant Apart from one fibroid culture and one myometrial culture all the others revealed strong TNC immunostaining Expression of TSP 1 and SPARC osteonectin was weak to moderate in all established cell lines None of the tissues or cell lines investigated showed positive staining for TNX In conclusion TSP 1 and TNC are likely to play important roles in the pathogenesis of uterine leiomyomas presumably affecting cell proliferation and or extracellular matrix deposition Authors M Bogusiewicz A Semczuk M Juszczak E Langner K Walczak W Rzeski J Tomaszewski T Rechberger Related Documents 1125108 Nonvirionic inhibitor of dna synthesis in human embryo fibroblast cell cultures infecte 3258238 Cell cycle related metabolic and enzymatic events in proliferating rat thymocytes 1718328 Rapid small scale rna isolation from tissue culture cells 4591948 Deoxyribonucleic acid synthesis during the division cycle of escherichia coli a compar 19031368 A promising anticancer and antimalarial component from the leaves of bidens pilosa 4737378 The uptake of gamma aminobutyrate by organotypic cultures of chick spinal cord Publication Detail Type Journal Article Journal Detail Title Histology and histopathology Volume 27 ISSN 1699 5848 ISO Abbreviation Histol Histopathol Publication Date 2012 Nov Date Detail Created Date 2012 09 28 Completed Date Revised Date Medline Journal Info Nlm
    http://www.biomedsearch.com/nih/Expression-matricellular-proteins-in-human/23018248.html (2012-10-12)

  • The appropriateness method has acceptable reliability and validity for assessing overuse and underuse of surgical procedures.
    identified and 37 met the inclusion criteria The test retest reliability is good to very good kappa 0 64 0 81 for total knee and hip joint replacement coronary artery bypass grafting CABG and carotid endarterectomy CEA The interpanel reliability is moderate to very good kappa 0 52 0 83 for CABG and hysterectomy Construct validity has been demonstrated by comparing the appropriateness method with guidelines and or evidence based approaches for endoscopy colonoscopy CABG hysterectomy and CEA Predictive validity has been studied for cardiac revascularization in which concordance with appropriateness classification is associated with better clinical outcomes CONCLUSION Our findings support use of the appropriateness method to assess variation in the rates of the procedures studied by identifying overuse and underuse Further methodological research should be conducted as appropriateness criteria are developed and implemented for a broader range of procedures Authors Elise H Lawson Melinda Maggard Gibbons Clifford Y Ko Paul G Shekelle Publication Detail Type Journal Article Journal Detail Title Journal of clinical epidemiology Volume 65 ISSN 1878 5921 ISO Abbreviation J Clin Epidemiol Publication Date 2012 Nov Date Detail Created Date 2012 09 28 Completed Date Revised Date Medline Journal Info Nlm Unique ID 8801383 Medline TA
    http://www.biomedsearch.com/nih/appropriateness-method-has-acceptable-reliability/23017632.html (2012-10-12)

  • A framework for understanding cancer comparative effectiveness research data needs.
    articulating cancer comparative effectiveness research data needs STUDY DESIGN AND SETTING We examined prevalent models and conducted semi structured discussions with 76 clinicians and comparative effectiveness research researchers affiliated with the Agency for Healthcare Research and Quality s cancer comparative effectiveness research programs RESULTS A new model was iteratively developed and presents cancer comparative effectiveness research and important measures in a patient centered longitudinal chronic care model better reflecting contemporary cancer care in the context of the cancer care continuum rather than a single episode acute care perspective CONCLUSION Immediately relevant for federally funded comparative effectiveness research programs the model informs an evolving framework articulating cancer comparative effectiveness research data needs including evolutionary enhancements to registries and epidemiologic research data systems We discuss elements of contemporary clinical practice methodology improvements and related needs affecting comparative effectiveness research s ability to yield findings clinicians policy makers and stakeholders can confidently act on Authors William R Carpenter Anne Marie Meyer Amy P Abernethy Til Stürmer Michael R Kosorok Related Documents 22823003 Attitudes to brain donation for parkinson s research and how to ask a qualitative stud 22629513 The breasts of tutankhamun 19017193 Myxomatous neoplasms in the perineal region of baboons Publication Detail Type Journal Article Journal Detail Title Journal of clinical epidemiology Volume 65 ISSN 1878 5921 ISO Abbreviation J Clin Epidemiol Publication Date 2012 Nov Date Detail Created Date 2012 09 28 Completed Date Revised Date Medline Journal Info Nlm Unique ID 8801383 Medline TA J Clin Epidemiol Country United States Other Details Languages eng Pagination 1150 8 Citation Subset IM Copyright Information Copyright 2012 Elsevier Inc All rights reserved Affiliation Department of Health Policy and Management Gillings School of Global Public Health University of North Carolina CB 7411 135 Dauer Drive Chapel Hill NC 27599 USA Cecil G Sheps Center
    http://www.biomedsearch.com/nih/framework-understanding-cancer-comparative-effectiveness/23017633.html (2012-10-12)