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  • Cell Research
    1 1 2012 6 8 Investigating the bona fide differentiation capacity of human pluripotent stem cells Jian Chien Dominic Heng 1 2 Kyle M Loh 1 and Huck Hui Ng 1 2 1 Gene Regulation Laboratory Genome Institute of Singapore 60 Biopolis Street Singapore 138672 2 Graduate School for Integrative Sciences Engineering National University of Singapore 28 Medical Drive Singapore 117456 Correspondence Huck Hui Ng Tel 65 68088145 E mail

    Original URL path: http://www.cell-research.com/arts.asp?id=227 (2016-02-14)
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  • Cell Research
    1 1 2012 12 13 Watching lymphatic vessels grow by making them glow Steven T Proulx and Michael Detmar Institute of Pharmaceutical Sciences Swiss Federal Institute of Technology ETH Zurich Wolfgang Pauli Strasse 10 8093 Zurich Switzerland Correspondence Michael Detmar E mail michael detmar pharma ethz ch A novel imaging technique for visualizing the growth of lymphatic vessels in the cornea is summarized Comparison to existing lymphatic imaging approaches and

    Original URL path: http://www.cell-research.com/arts.asp?id=229 (2016-02-14)
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  • Cell Research
    Forest Park Road Dallas Texas 75390 9041 USA Correspondence Melanie H Cobb Tel 1 214 645 6122 E mail Melanie Cobb UTSouthwestern edu The extracellular signal regulated kinase 1 2 ERK1 2 cascade is the prototype mammalian mitogen activated protein kinase MAPK signaling cascade that regulates a number of processes including proliferation differentiation survival migration stress responses and apoptosis How this seemingly linear cascade is modulated to achieve a specific

    Original URL path: http://www.cell-research.com/arts.asp?id=230 (2016-02-14)
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  • Cell Research
    Publication Current Issue Top 10 VOLUME 22 ISSUE 1 1 2012 23 32 Semaphorin signaling in angiogenesis lymphangiogenesis and cancer Atsuko Sakurai Colleen Doci and J Silvio Gutkind Oral and Pharyngeal Cancer Branch National Institute of Dental and Craniofacial Research National Institutes of Health 30 Convent Drive Rm 211 Bethesda MD 20892 USA Correspondence J Silvio Gutkind Tel 1 301 496 3695 E mail sg39v nih gov Angiogenesis the formation of new blood vessels from preexisting vasculature is essential for many physiological processes and aberrant angiogenesis contributes to some of the most prevalent human diseases including cancer Angiogenesis is controlled by delicate balance between pro and anti angiogenic signals While pro angiogenic signaling has been extensively investigated how developmentally regulated naturally occurring anti angiogenic molecules prevent the excessive growth of vascular and lymphatic vessels is still poorly understood In this review we summarize the current knowledge on how semaphorins and their receptors plexins and neuropilins control normal and pathological angiogenesis with an emphasis on semaphorin regulated anti angiogenic signaling circuitries in vascular and lymphatic endothelial cells This emerging body of information may afford the opportunity to develop novel anti angiogenic therapeutic strategies Cell Research 2012 22 23 32 doi 10

    Original URL path: http://www.cell-research.com/arts.asp?id=231 (2016-02-14)
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  • Cell Research
    Cellular Stress Biology and School of Life Sciences Xiamen University Xiamen Fujian 361005 China 2 Department of Automation Xiamen University Xiamen Fujian 361005 China Correspondence Jiahuai Han E mail jhan xmu edu cn Historically sharing T cell receptors TCRs between individuals has been speculated to be impossible considering the dramatic discrepancy between the potential enormity of the TCR repertoire and the limited number of T cells generated in each individual However public T cell response in which multiple individuals share identical TCRs in responding to a same antigenic epitope has been extensively observed in a variety of immune responses across many species Public T cell responses enable individuals within a population to generate similar antigen specific TCRs against certain ubiquitous pathogens leading to favorable biological outcomes However the relatively concentrated feature of TCR repertoire may limit T cell response in a population to some other pathogens It could be a great benefit for human health if public T cell responses can be manipulated Therefore the mechanistic insight of public TCR generation is important to know Recently high throughput DNA sequencing has revolutionized the study of immune receptor repertoires which allows a much better understanding of the factors that determine the

    Original URL path: http://www.cell-research.com/arts.asp?id=232 (2016-02-14)
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  • Cell Research
    Zwijnaarde Belgium 2 Department of Biomedical Molecular Biology Unit for Molecular Signaling and Cell Death Ghent University Technologiepark 927 B 9052 Ghent Belgium 3 KULeuven Laboratory for Cell Death and Therapy Department for Molecular and Cell Biology O N I Herestraat 49 B 3000 Leuven Belgium Correspondence Peter Vandenabeele Tel 32 9 3313763 E mail Peter Vandenabeele dmbr vib UGent be Autophagy is a lysosomal degradation pathway that degrades damaged or superfluous cell components into basic biomolecules which are then recycled back into the cytosol In this respect autophagy drives a flow of biomolecules in a continuous degradation regeneration cycle Autophagy is generally considered a pro survival mechanism protecting cells under stress or poor nutrient conditions Current research clearly shows that autophagy fulfills numerous functions in vital biological processes It is implicated in development differentiation innate and adaptive immunity ageing and cell death In addition accumulating evidence demonstrates interesting links between autophagy and several human diseases and tumor development Therefore autophagy seems to be an important player in the life and death of cells and organisms Despite the mounting knowledge about autophagy the mechanisms through which the autophagic machinery regulates these diverse processes are not entirely understood In this review

    Original URL path: http://www.cell-research.com/arts.asp?id=233 (2016-02-14)
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  • Cell Research
    Avda de la Ilustración 14 Granada 18007 Granada Spain Correspondence Pablo Menendez Rene Rodriguez Tel 34 958 894 672 E mail pablo menendez genyo es rene rodriguez genyo es Because of their unique properties multipotent mesenchymal stem cells MSCs represent one of the most promising adult stem cells being used worldwide in a wide array of clinical applications Overall compelling evidence supports the long term safety of ex vivo expanded human MSCs which do not seem to transform spontaneously However experimental data reveal a link between MSCs and cancer and MSCs have been reported to inhibit or promote tumor growth depending on yet undefined conditions Interestingly solid evidence based on transgenic mice and genetic intervention of MSCs has placed these cells as the most likely cell of origin for certain sarcomas This research area is being increasingly explored to develop accurate MSC based models of sarcomagenesis which will be undoubtedly valuable in providing a better understanding about the etiology and pathogenesis of mesenchymal cancer eventually leading to the development of more specific therapies directed against the sarcoma initiating cell Unfortunately still little is known about the mechanisms underlying MSC transformation and further studies are required to develop bona fide sarcoma

    Original URL path: http://www.cell-research.com/arts.asp?id=234 (2016-02-14)
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  • Cell Research
    Mary Wiese 1 3 and Hui Zheng 1 2 3 1 Huffington Center on Aging Baylor College of Medicine One Baylor Plaza BCM MS230 Houston TX 77030 USA 2 Program in Translational Biology and Molecular Medicine Houston TX 77030 USA 3 Department of Molecular and Human Genetics Baylor College of Medicine Houston TX 77030 USA Correspondence Hui Zheng Tel 1 713 798 1568 E mail huiz bcm edu The amyloid precursor protein APP has been under intensive study in recent years mainly due to its critical role in the pathogenesis of Alzheimer s disease AD β Amyloid Aβ peptides generated from APP proteolytic cleavage can aggregate leading to plaque formation in human AD brains Point mutations of APP affecting Aβ production are found to be causal for hereditary early onset familial AD It is very likely that elucidating the physiological properties of APP will greatly facilitate the understanding of its role in AD pathogenesis A number of APP loss and gain of function models have been established in model organisms including Caenorhabditis elegans Drosophila zebrafish and mouse These in vivo models provide us valuable insights into APP physiological functions In addition several knock in mouse models expressing mutant APP at

    Original URL path: http://www.cell-research.com/arts.asp?id=281 (2016-02-14)
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