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  • Cell Research
    2 College of Life Science Northeast Agricultural University of China Harbin 150030 China 3 Center for Regenerative Medicine Beijing Institute of Geriatrics Xuanwu Hospital Capital Medical University Beijing China and Key Laboratory of Neurodegeneration Ministry of Education Beijing 100053 China 4 State Key Laboratory of Brain and Cognitive Sciences Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China 5 State Key Laboratory of Plant Genomics Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 China 6 Graduate School of Chinese Academy of Sciences Beijing 100049 China Correspondence Zhiguo Chen Qi Zhou E mail chenzhiguo gmail com qzhou ioz ac cn Multipotent neural stem progenitor cells hold great promise for cell therapy The reprogramming of fibroblasts to induced pluripotent stem cells as well as mature neurons suggests a possibility to convert a terminally differentiated somatic cell into a multipotent state without first establishing pluripotency Here we demonstrate that sertoli cells derived from mesoderm can be directly converted into a multipotent state that possesses neural stem progenitor cell properties The induced neural stem progenitor cells iNSCs express multiple NSC specific markers exhibit a global gene expression profile similar to normal NSCs and are capable of self renewal and

    Original URL path: http://www.cell-research.com/arts.asp?id=244 (2016-02-14)
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  • Cell Research
    Center SK Biopharmaceuticals Co Ltd Daejeon 305 712 Korea 3 Graduate School of Medicine Laboratory of G Protein Coupled Receptor Korea University Seoul 135 705 Korea 4 Probiond Co Ltd Seoul 143 834 Korea 5 College of Pharmacy and Research Institute for Drug Development Pusan National University Busan 609 735 Korea 6 Division of Molecular and Life Sciences POSTECH Pohang 790 784 Korea 7 Department of Bioscience and Biotechnology Konkuk University Seoul 143 701 Korea Correspondence Sangtaek Oh Tel 82 2 910 5732 E mail ohsa kookmin ac kr The Wnt β catenin pathway plays important roles in the differentiation of multiple cell types including mesenchymal stem cells Using a cell based chemical screening assay with a synthetic chemical library of 270 000 compounds we identified the compound SKL2001 as a novel agonist of the Wnt β catenin pathway and uncovered its molecular mechanism of action SKL2001 upregulated β catenin responsive transcription by increasing the intracellular β catenin protein level and inhibited the phosphorylation of β catenin at residues Ser33 37 Thr41 and Ser45 which would mark it for proteasomal degradation without affecting CK1 and GSK 3β enzyme activities Biochemical analysis revealed that SKL2001 disrupted the Axin β catenin interaction

    Original URL path: http://www.cell-research.com/arts.asp?id=246 (2016-02-14)
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  • Cell Research
    Biotherapy West China Hospital West China Medical School Sichuan University Chengdu 610041 China 2 Department of Gastrointestinal Surgery State Key Laboratory of Biotherapy West China Hospital West China Medical School Sichuan University Chengdu 610041 China 3 Oncology State Key Laboratory of Biotherapy West China Hospital West China Medical School Sichuan University Chengdu 610041 China Correspondence Jiankun Hu Xianming Mo Tel 86 28 81812851 86 28 81812851 E mail hujkwch 126 com xmingmo yahoo com Gastric cancer is the fourth most common cancer worldwide with a high rate of death and low 5 year survival rate To date there is a lack of efficient therapeutic protocols for gastric cancer Recent studies suggest that cancer stem cells CSCs are responsible for tumor initiation invasion metastasis and resistance to anticancer therapies Thus therapies that target gastric CSCs are attractive However CSCs in human gastric adenocarcinoma GAC have not been described Here we identify CSCs in tumor tissues and peripheral blood from GAC patients CSCs of human GAC GCSCs that are isolated from tumor tissues and peripheral blood of patients carried CD44 and CD54 surface markers generated tumors that highly resemble the original human tumors when injected into immunodeficient mice differentiated into gastric epithelial

    Original URL path: http://www.cell-research.com/arts.asp?id=247 (2016-02-14)
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  • Cell Research

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    Original URL path: /artsmore1.asp?id=17 (2016-02-14)


  • Cell Research
    Universitaetsklinikum Hamburg Eppendorf 20246 Hamburg Germany 3 Howard Hughes Medical Institute Correspondence Richard A Flavell E mail Richard flavell yale edu We all have been taught that the immune system is educated in the thymus however where the immune system receives the second lesson in order to be tolerant against non harmful pathogens such as commensal bacteria has never been addressed Considering that commensal bacteria colonize the intestine and that

    Original URL path: http://www.cell-research.com/arts.asp?id=208 (2016-02-14)
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  • Cell Research
    Gaur The Scripps Research Institute Department of Immunology and Microbial Science IMM22 10550 N Torrey Pines Rd La Jolla CA 92037 USA Correspondence Ann J Feeney Tel 1 858 784 2979 E mail feeney scripps edu The CTCF cohesin complex regulates higher order chromatin structure by creating long range chromatin loops and by insulating neighboring genes from each other The lymphocyte antigen receptor loci have large numbers of CTCF cohesin

    Original URL path: http://www.cell-research.com/arts.asp?id=209 (2016-02-14)
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  • Cell Research
    and Juan Carlos Izpisua Belmonte 1 3 1 Gene Expression Laboratory Salk Institute for Biological Studies 10010 North Torrey Pines Road La Jolla California 92037 USA 2 National Laboratory of Biomacromolecules Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China 3 Center for Regenerative Medicine in Barcelona Dr Aiguader 88 08003 Barcelona Spain Correspondence Juan Carlos Izpisua Belmonte E mail belmonte salk edu izpisua cmrb eu Gene editing technologies

    Original URL path: http://www.cell-research.com/arts.asp?id=210 (2016-02-14)
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  • Cell Research
    Issue Submission Advanced Online Publication Current Issue Top 10 VOLUME 22 ISSUE 2 2 2012 285 287 K Ras and mitochondria Dangerous liasons Jiri Neuzil 1 2 Jakub Rohlena 2 and Lan Feng Dong 1 1 Apoptosis Research Group School of Medical Science and the Griffith Health Institute Griffith University Gold Coast Campus Southport 4222 Qld Australia 2 Institute of Biotechnology Academy of Sciences of the Czech Republic Prague Czech Republic Correspondence Jiri Neuzil Tel 61 2 55529109 E mail j neuzil griffith edu au It is well documented that the K RAS oncogene efficiently transforms non malignant cells and there is some evidence for the role of mitochondria in this process Now Peng Huang and colleagues show that K Ras induction results early on in mitochondria assuming the phenotype consistent with the so called Warburg effect i e increased glycolysis and attenuated oxidative phosphorylation Thus the K Ras protein capable of swift induction of phenotypic changes typical of cancer cells yet these changes are reversible and for cells to irreversibly reach their full malignant potential a much longer K Ras expression is required implicating mitochondria in the longer term effects of the oncogene Cell Research 2012 22 285 287

    Original URL path: http://www.cell-research.com/arts.asp?id=211 (2016-02-14)
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