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  • Cell Research
    3 Li Feng 2 Helene Pelicano 2 1 State Key Laboratory of Oncology in Southern China Sun Yat Sen University Cancer Center Guangzhou 510275 China 2 Department of Molecular Pathology Unit 951 The University of Texas MD Anderson Cancer Center 1515 Holcombe Boulevard Houston TX 77030 USA 3 Faculty of Dentistry Thammasat University Pathum thani 12121 Thailand 4 Department of Surgical Oncology The University of Texas MD Anderson Cancer Center Houston TX 77030 USA 5 Department of Leukemia The University of Texas MD Anderson Cancer Center Houston TX 77030 USA Correspondence Peng Huang Tel 1 713 834 6044 E mail phuang mdanderson org Increased aerobic glycolysis and oxidative stress are important features of cancer cell metabolism but the underlying biochemical and molecular mechanisms remain elusive Using a tetracycline inducible model we show that activation of K ras G12V causes mitochondrial dysfunction leading to decreased respiration elevated glycolysis and increased generation of reactive oxygen species The K RAS protein is associated with mitochondria and induces a rapid suppression of respiratory chain complex I and a decrease in mitochondrial transmembrane potential by affecting the cyclosporin sensitive permeability transition pore Furthermore pre induction of K ras G12V expression in vitro to allow metabolic

    Original URL path: http://www.cell-research.com/arts.asp?id=219 (2016-02-14)
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  • Cell Research
    Liwen Jiang 2 Karin Schumacher 1 Department of Botany and Plant Sciences Center for Plant Cell Biology Institute for Integrative Genome Biology 4119C Genomics Building University of California Riverside CA 92521 USA 2 School of Life Sciences Center for Cell and Developmental Biology Chinese University of Hong Kong New Territories Hong Kong China 3 Heidelberg Institute for Plant Science Im Neuenheimer Feld 230 Heidelberg 69120 Germany 4 Complex Carbohydrate Research Center University of Georgia Athens GA 30602 USA 5 NuSep Inc Bogart GA 30622 USA 6 Current address Department of Plant Sciences University of California Davis CA 95616 USA 7 Current address Department of Molecular and Cell Biology University of California Berkeley CA 94720 USA Correspondence Natasha Raikhel E mail nraikhel ucr edu The endomembrane system is a complex and dynamic intracellular trafficking network It is very challenging to track individual vesicles and their cargos in real time however affinity purification allows vesicles to be isolated in their natural state so that their constituent proteins can be identified Pioneering this approach in plants we isolated the SYP61 trans Golgi network compartment and carried out a comprehensive proteomic analysis of its contents with only minimal interference from other organelles The proteome of SYP61 revealed the association of proteins of unknown function that have previously not been ascribed to this compartment We identified a complete SYP61 SNARE complex including regulatory proteins and validated the proteome data by showing that several of these proteins associated with SYP61 in planta We further identified the SYP121 complex and cellulose synthases suggesting that SYP61 plays a role in the exocytic trafficking and the transport of cell wall components to the plasma membrane The presence of proteins of unknown function in the SYP61 proteome including ECHIDNA offers the opportunity to identify novel trafficking components and cargos The

    Original URL path: http://www.cell-research.com/arts.asp?id=220 (2016-02-14)
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  • Cell Research
    Drosophila Xianjue Ma Jiuhong Huang Lixia Yang Yang Yang Wenzhe Li and Lei Xue Shanghai Key Laboratory for Signaling and Diseases School of Life Science and Technology Tongji University 1239 Siping Road Shanghai 200092 China Correspondence Lei Xue Tel 86 21 65985407 E mail lei xue tongji edu cn Tumor necrosis factor TNF family ligands play essential roles in regulating a variety of cellular processes including proliferation differentiation and survival Expression of Drosophila TNF ortholog Eiger Egr induces JNK dependent cell death while the roles of caspases in this process remain elusive To further delineate the Egr triggered cell death pathway we performed a genetic screen to identify dominant modifiers of the Egr induced cell death phenotype Here we report that Egr elicits a caspase mediated cell death pathway independent of JNK signaling Furthermore we show NOPO the Drosophila ortholog of TRIP TRAF interacting protein encoding an E3 ubiquitin ligase modulates Egr induced Caspase mediated cell death through transcriptional activation of pro apoptotic genes reaper and hid Finally we found Bendless and dUEV1a an ubiquitin conjugating E2 enzyme complex regulates NOPO triggered cell death Our results indicate that the Ben dUEV1a complex constitutes a molecular switch that bifurcates the Egr

    Original URL path: http://www.cell-research.com/arts.asp?id=221 (2016-02-14)
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  • Cell Research
    is required for self renewal and differentiation of adult human stem cells Souzan Salemi 1 Shida Yousefi 1 Mihai A Constantinescu 2 Martin F Fey 3 and Hans Uwe Simon 1 1 Institute of Pharmacology University of Bern Bern Switzerland 2 Department of Plastic Reconstructive and Aesthetic Surgery University Hospital Bern Bern Switzerland 3 Institute of Medical Oncology University Hospital Bern University of Bern CH 3010 Bern Switzerland Correspondence Hans

    Original URL path: http://www.cell-research.com/arts.asp?id=222 (2016-02-14)
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  • Cell Research
    Jianwei Jiao 5 1 Department of ophthalmology Eye ENT Hospital Fudan University 83 Fenyang Rd Shanghai 200031 China 2 Institute of Neuroscience State Key Laboratory of Neuroscience Shanghai Institutes for Biological Sciences Chinese Academy of Sciences 320 Yueyang Rd Shanghai 200031 China 3 Fudan University Shanghai Medical College Shanghai 200032 China 4 Department of Ophthalmology Ninth People s Hospital Shanghai Jiao Tong University School of Medicine 639 Zhizaoju Rd Shanghai

    Original URL path: http://www.cell-research.com/arts.asp?id=223 (2016-02-14)
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  • Cell Research

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    Original URL path: /artsmore1.asp?id=16 (2016-02-14)


  • Cell Research
    and Lewis C Cantley Beth Israel Deaconess Medical Center Department of Medicine Division of Signal Transduction Department of Systems Biology Harvard Medical School Boston MA 02115 USA E mail lewis cantley hms harvard edu Many cancer cells depend on glutamine as a fuel for proliferation yet the mechanisms by which glutamine supports cancer metabolism are not fully understood Two recent studies highlight an important role for glutamine in the synthesis

    Original URL path: http://www.cell-research.com/arts.asp?id=191 (2016-02-14)
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  • Cell Research
    620 University Avenue Toronto ON M5C 2M9 Canada 2 The Department of Medical Biophysics University of Toronto 610 University Avenue Toronto ON M5G 2C1 Canada Correspondence Tak Wah Mak E mail tmak uhnres utoronto ca Pyruvate kinase catalyzes the transfer of a high energy phosphate group from phosphoenol pyruvate PEP to generate pyruvate and ATP a reaction that is the rate limiting step of the glycolytic pathway The PKM1 alternatively

    Original URL path: http://www.cell-research.com/arts.asp?id=192 (2016-02-14)
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