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  • Cell Research
    7 A 1030 Vienna Austria 2 Laboratory of Molecular Cell Biology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Yueyang Road 320 Shanghai 200031 China 3 F BBVA CNIO Cancer Cell Biology Programme Spanish National Cancer Research Centre Melchor Fernández Almagro 3 E 28029 Madrid Spain 4 Deceased While this manuscript was in revision Dr Hartmut Beug passed away after a heroic fight against cancer We dedicate this work to his memory Correspondence Lijian Hui Tel 86 21 5492 1328 E mail ljhui sibs ac cn Enucleation of erythroblasts during terminal differentiation is unique to mammals Although erythroid enucleation has been extensively studied only a few genes including retinoblastoma protein Rb have been identified to regulate nuclear extrusion It remains largely undefined by which signaling molecules the extrinsic stimuli such as erythropoietin Epo are transduced to induce enucleation Here we show that p38α a mitogen activated protein kinase MAPK is required for erythroid enucleation In an ex vivo differentiation system that contains high Epo levels and mimics stress erythropoiesis p38α is activated during erythroid differentiation Loss of p38α completely blocks enucleation of primary erythroblasts Moreover p38α regulates erythroblast enucleation in a cell autonomous

    Original URL path: http://www.cell-research.com/arts.asp?id=201 (2016-02-14)
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  • Cell Research
    KU Leuven Department of Molecular Cell Biology Laboratory Ion Channel Research Campus Gasthuisberg Herestraat 49 B 3000 Leuven Belgium 3 Institute of Vascular Medicine Li Ka Shing Institute of Health Sciences and School of Biomedical Sciences Chinese University of Hong Kong Hong Kong China Correspondence Zhiming Zhu Zhencheng Yan Tel 86 23 68767849 E mail zhuzm yahoo com zhenchengyan sina com Impaired aerobic exercise capacity and skeletal muscle dysfunction are associated with cardiometabolic diseases Acute administration of capsaicin enhances exercise endurance in rodents but the long term effect of dietary capsaicin is unknown The capsaicin receptor the transient receptor potential vanilloid 1 TRPV1 cation channel has been detected in skeletal muscle the role of which remains unclear Here we report the function of TRPV1 in cultured C2C12 myocytes and the effect of TRPV1 activation by dietary capsaicin on energy metabolism and exercise endurance of skeletal muscles in mice In vitro capsaicin increased cytosolic free calcium and peroxisome proliferator activated receptor coactivator 1a PGC 1α expression in C2C12 myotubes through activating TRPV1 In vivo PGC 1α in skeletal muscle was upregulated by capsaicin induced TRPV1 activation or genetic overexpression of TRPV1 in mice TRPV1 activation increased the expression of genes involved

    Original URL path: http://www.cell-research.com/arts.asp?id=202 (2016-02-14)
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  • Cell Research
    2 and Hongbin Ji 1 1 State Key Laboratory of Cell Biology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences SIBS Chinese Academy of Sciences Shanghai 200031 China 2 School of Life Sciences Institute of Biostatistics Fudan University Shanghai 200433 China Correspondence Hongbin Ji Weidong Tian E mail hbji sibs ac cn weidong tian fudan edu cn Classical algorithms aiming at identifying biological pathways significantly related to studying conditions frequently reduced pathways to gene sets with an obvious ignorance of the constitutive non equivalence of various genes within a defined pathway We here designed a network based method to determine such non equivalence in terms of gene weights The gene weights determined are biologically consistent and robust to network perturbations By integrating the gene weights into the classical gene set analysis with a subsequent correction for the over counting bias associated with multi subunit proteins we have developed a novel gene weighed pathway analysis approach as implemented in an R package called Gene Associaqtion Network based Pathway Analysis GANPA Through analysis of several microarray datasets including the p53 dataset asthma dataset and three breast cancer datasets we demonstrated that our approach is biologically reliable and reproducible and

    Original URL path: http://www.cell-research.com/arts.asp?id=203 (2016-02-14)
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  • Cell Research
    China Correspondence Hong Wei Xue Tel 86 21 54924059 E mail hwxue sibs ac cn Phosphatidylinositol monophosphate 5 kinase PIP5K catalyzes the synthesis of PI 4 5 bisphosphate PtdIns 4 5 P 2 by phosphorylation of PI 4 phosphate at the 5 position of the inositol ring and is involved in regulating multiple developmental processes and stress responses We here report on the functional characterization of Arabidopsis PIP5K2 which is expressed during lateral root initiation and elongation and whose expression is enhanced by exogenous auxin The knockout mutant pip5k2 shows reduced lateral root formation which could be recovered with exogenous auxin and interestingly delayed root gravity response that could not be recovered with exogenous auxin Crossing with the DR5 GUS marker line and measurement of free IAA content confirmed the reduced auxin accumulation in pip5k2 In addition analysis using the membrane selective dye FM4 64 revealed the decelerated vesicle trafficking caused by PtdIns 4 5 P 2 reduction which hence results in suppressed cycling of PIN proteins PIN2 and 3 and delayed redistribution of PIN2 and auxin under gravistimulation in pip5k2 roots On the contrary PtdIns 4 5 P 2 significantly enhanced the vesicle trafficking and cycling of PIN proteins

    Original URL path: http://www.cell-research.com/arts.asp?id=204 (2016-02-14)
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  • Cell Research
    interactions with RbBP5 and DPY30 Yong Chen 1 2 Fang Cao 3 Bingbing Wan 1 2 Yali Dou 2 3 and Ming Lei 1 2 1 Howard Hughes Medical Institute University of Michigan Medical School 1150 W Medical Center Drive Ann Arbor MI 48109 USA 2 Department of Biological Chemistry University of Michigan Medical School 1150 W Medical Center Drive Ann Arbor MI 48109 USA 3 Department of Pathology University

    Original URL path: http://www.cell-research.com/arts.asp?id=205 (2016-02-14)
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  • Cell Research
    ISSUE 3 3 2012 603 606 The E3 ubiquitin ligase MIB1 negatively regulates basal IκBα level and modulates NF κB activation Li Juan Liu Tian Tian Liu Yong Ran Ying Li Xiao Dong Zhang Hong Bing Shu and Yan Yi Wang College of Life Sciences Wuhan University Wuhan Hubei 430072 China Correspondence Hong Bing Shu Yan Yi Wang Tel 86 27 68753795 86 27 68753861 E mail shuh whu edu

    Original URL path: http://www.cell-research.com/arts.asp?id=206 (2016-02-14)
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  • Cell Research
    exosomes from TGF β1 gene modified dendritic cells attenuate Th17 mediated inflammatory autoimmune disease by inducing regulatory T cells Zhijian Cai 1 Wei Zhang 1 Fei Yang 1 Lei Yu 1 Zhou Yu 1 JihHung Pan 2 Lie Wang 1 Xuetao Cao 1 and Jianli Wang 1 1 Institute of Immunology Zhejiang University School of Medicine Hangzhou Zhejiang 310058 China 2 Hangzhou Wahaha group Co Ltd Hangzhou Zhejiang 310018 China

    Original URL path: http://www.cell-research.com/arts.asp?id=207 (2016-02-14)
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  • Cell Research

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    Original URL path: /artsmore1.asp?id=15 (2016-02-14)




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