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  • Cell Research
    Cabrera 1 Madrid 28049 Spain Correspondence Paola Bovolenta E mail pbovolenta cbm uam es Shh and Wnts secreted by the floor and roof plate of the spinal cord direct longitudinal growth of the axons from the adjacent ventral funiculus and cortico spinal tract Whether these midline cues influence the directionality of axons elongating in more lateral positions of the spinal cord is unexplored Song and colleagues investigate this possibility and

    Original URL path: http://www.cell-research.com/arts.asp?id=174 (2016-02-14)
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  • Cell Research
    School of Medicine Institute for Biogenesis Research University of Hawaii 651 Ilalo St Biomedical Science Bldg Room 163B Honolulu HI 96813 USA Correspondence Richard Allsopp Tel 1 808 692 1412 E mail allsopp hawaii edu A hallmark feature of pluripotent stem cells is the ability to proliferate indefinitely immortal phenotype Despite reactivation of telomerase during iPSC derivation there exists considerable heterogeneity in telomere length amongst established iPSC cell lines Both

    Original URL path: http://www.cell-research.com/arts.asp?id=175 (2016-02-14)
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  • Cell Research
    Center for Regenerative Medicine in Barcelona Dr Aiguader 88 08003 Barcelona Spain 3 National Laboratory of Biomacromolecules Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China Correspondence Juan Carlos Izpisua Belmonte Guang Hui Liu E mail belmonte salk edu izpisua cmrb eu ghliu ibp ac cn Induced pluripotent stem cells iPSCs and the cell transdifferentiation technologies are providing powerful tools to generate patient specific cells for research and therapeutic

    Original URL path: http://www.cell-research.com/arts.asp?id=176 (2016-02-14)
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  • Cell Research
    Publication Current Issue Top 10 VOLUME 22 ISSUE 4 4 2012 620 623 Defining the expressed breast cancer kinome Alicia A Midland 1 Martin C Whittle 2 James S Duncan 2 Amy N Abell 2 Kazuhiro Nakamura 2 Jon S Zawistowski 2 Lisa A Carey 3 H Shelton Earp III 3 Lee M Graves 1 Biomedical Engineering and Curriculum in Bioinformatics and Computational Biology Lineberger Comprehensive Cancer Center University of North Carolina School of Medicine Chapel Hill NC 27599 USA 2 Department of Pharmacology Lineberger Comprehensive Cancer Center University of North Carolina School of Medicine Chapel Hill NC 27599 USA 3 Department of Medicine Lineberger Comprehensive Cancer Center University of North Carolina School of Medicine Chapel Hill NC 27599 USA Correspondence Gary L Johnson Tel 1 919 843 3107 E mail glj med unc edu Protein kinases are arguably the most tractable candidates for development of new therapies to treat cancer Deep sequencing of breast cancer cell lines indicates each express 375 or so kinases representing nearly 75 of the kinome A rich network both downstream and upstream from key oncogenic kinases includes both tyrosine and serine threonine kinases giving plasticity and resiliency to the cancer cell kinome Cell Research

    Original URL path: http://www.cell-research.com/arts.asp?id=177 (2016-02-14)
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  • Cell Research
    Botany and Plant Sciences Institute of Integrative Genome Biology University of California Riverside CA 92521 USA 2 Howard Hughes Medical Institute Department of Botany and Plant Sciences Institute of Integrative Genome Biology University of California Riverside CA 92521 USA Correspondence Xuemei Chen Tel 1 951 827 3988 E mail xuemei chen ucr edu As central components of RNA silencing small RNAs play diverse and important roles in many biological processes in eukaryotes Aberrant reduction or elevation in the levels of small RNAs is associated with many developmental and physiological defects The in vivo levels of small RNAs are precisely regulated through modulating the rates of their biogenesis and turnover 2 O methylation on the 3 terminal ribose is a major mechanism that increases the stability of small RNAs The small RNA methyltransferase HUA ENHANCER1 HEN1 and its homologs methylate microRNAs and small interfering RNAs siRNAs in plants Piwi interacting RNAs piRNAs in animals and siRNAs in Drosophila 3 nucleotide addition especially uridylation and 3 5 exonucleolytic degradation are major mechanisms that turnover small RNAs Other mechanisms impacting small RNA stability include complementary RNAs cis elements in small RNA sequences and RNA binding proteins Investigations are ongoing to further understand how

    Original URL path: http://www.cell-research.com/arts.asp?id=178 (2016-02-14)
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  • Cell Research
    1 National Institute of Biological Sciences Zhongguancun Life Science Park 7 Science Park Road Beijing 102206 China 2 Guangxi Zhuang Autonomous Region Women and Children Care Hospital Nanning Guangxi 530003 China 3 National Institute of Geriatrics Beijing Hospital Chinese Ministry of Health Beijing 100730 China Correspondence Shaorong Gao Ze Yang E mail gaoshaorong nibs ac cn yangze016 yahoo com cn The generation of induced pluripotent stem cells iPSCs from differentiated somatic cells by over expression of several transcription factors has the potential to cure many genetic and degenerative diseases currently recalcitrant to traditional clinical approaches One such genetic disease is β thalassemia major Cooley s anemia This disease is caused by either a point mutation or the deletion of several nucleotides in the β globin gene and it threatens the lives of millions of people in China In the present study we successfully generated iPSCs from fibroblasts collected from a 2 year old patient who was diagnosed with a homozygous 41 42 deletion in his β globin gene More importantly we successfully corrected this genetic mutation in the β thalassemia iPSCs by homologous recombination Furthermore transplantation of the genetically corrected iPSCs derived hematopoietic progenitors into sub lethally irradiated immune deficient

    Original URL path: http://www.cell-research.com/arts.asp?id=179 (2016-02-14)
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  • Cell Research
    1 Liya Zhu 2 Zhenlan Liu 1 Letian Chen 1 State Key Laboratory for Conservation and Utilization of Subtropical Agro bioresources College of Life Sciences South China Agricultural University Guangzhou Guangdong 510642 China 2 Zhongkai University of Agriculture and Engineering Guangzhou Guangdong 510225 China Correspondence Chuxiong Zhuang Yao Guang Liu E mail zhuangcx scau edu cn ygliu scau edu cn Photoperiod and thermo sensitive genic male sterility PGMS and TGMS are the core components for hybrid breeding in crops Hybrid rice based on the two line system using PGMS and TGMS lines has been successfully developed and applied widely in agriculture However the molecular mechanism underlying the control of PGMS and TGMS remains obscure In this study we mapped and cloned a major locus p tms12 1 photo or thermo sensitive genic male sterility locus on chromosome 12 which confers PGMS in the japonica rice line Nongken 58S NK58S and TGMS in the indica rice line Peiai 64S PA64S derived from NK58S A 2 4 kb DNA fragment containing the wild type allele P TMS12 1 was able to restore the pollen fertility of NK58S and PA64S plants in genetic complementation P TMS12 1 encodes a unique noncoding RNA which produces a 21 nucleotide small RNA that we named osa smR5864w A substitution of C to G in p tms12 1 the only polymorphism relative to P TMS12 1 is present in the mutant small RNA namely osa smR5864m Furthermore overexpression of a 375 bp sequence of P TMS12 1 in transgenic NK58S and PA64S plants also produced osa smR5864w and restored pollen fertility The small RNA was expressed preferentially in young panicles but its expression was not markedly affected by different day lengths or temperatures Our results reveal that the point mutation in p tms12 1 which probably leads

    Original URL path: http://www.cell-research.com/arts.asp?id=180 (2016-02-14)
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  • Cell Research
    Chinese Academy of Sciences Shanghai 200031 China 2 School of Biomedical Sciences University of Queensland Brisbane Australia Correspondence Yan Chen Tel 86 21 54920916 E mail ychen3 sibs ac cn Ras plays a pivotal role in many cellular activities and its subcellular compartmentalization provides spatial and temporal selectivity Here we report a mode of spatial regulation of Ras signaling in the Golgi apparatus by two highly homologous proteins PAQR10 and PAQR11 of the progestin and AdipoQ receptors family PAQR10 and PAQR11 are exclusively localized in the Golgi apparatus Overexpression of PAQR10 PAQR11 stimulates basal and EGF induced ERK phosphorylation and increases the expression of ERK target genes in a dose dependent manner Overexpression of PAQR10 PAQR11 markedly elevates Golgi localization of HRas NRas and KRas4A but not KRas4B PAQR10 and PAQR11 can also interact with HRas NRas and KRas4A but not KRas4B The increased Ras protein at the Golgi apparatus by overexpression of PAQR10 PAQR11 is in an active state Consistently knockdown of PAQR10 and PAQR11 reduces EGF stimulated ERK phosphorylation and Ras activation at the Golgi apparatus Intriguingly PAQR10 and PAQR11 are able to interact with RasGRP1 a guanine nucleotide exchange protein of Ras and increase Golgi localization of

    Original URL path: http://www.cell-research.com/arts.asp?id=181 (2016-02-14)
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