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  • Cell Research

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    Original URL path: /artsmore1.asp?id=14 (2016-02-14)



  • Cell Research
    of Molecular Cellular and Developmental Biology University of Michigan Ann Arbor MI 48109 USA 2 Laboratory of Molecular Biology National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health Bethesda MD 20892 USA Correspondence Daniel J Klionsky James H Hurley E mail klionsky umich edu hurley helix nih gov BECN1 plays a central role in determining cell fate acting as a balance point in the decision to

    Original URL path: http://www.cell-research.com/arts.asp?id=157 (2016-02-14)
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  • Cell Research
    22 ISSUE 5 5 2012 786 788 Insights into Chinese prostate cancer with RNA seq Anirban Sahu 1 Matthew K Iyer 1 and Arul M Chinnaiyan 1 2 3 4 5 1 Michigan Center for Translational Pathology University of Michigan Medical School 1400 E Medical Center Dr 5316 Cancer Center Ann Arbor MI 48109 0602 USA 2 Department of Pathology University of Michigan Medical School 1400 E Medical Center Dr 5316 Cancer Center Ann Arbor MI 48109 0602 USA 3 Department of Urology University of Michigan Medical School 1400 E Medical Center Dr 5316 Cancer Center Ann Arbor MI 48109 0602 USA 4 Comprehensive Cancer Center University of Michigan Medical School 1400 E Medical Center Dr 5316 Cancer Center Ann Arbor MI 48109 0602 USA 5 Howard Hughes Medical Institute University of Michigan Medical School 1400 E Medical Center Dr 5316 Cancer Center Ann Arbor MI 48109 0602 USA Correspondence Arul M Chinnaiyan Tel 1 734 615 4062 E mail arul umich edu The prevalence of certain driver mutations in prostate cancer varies across ethnic populations A recent study uses RNA seq to profile the mutational landscape of prostate cancer in a Chinese population to gain additional insights on ethnic

    Original URL path: http://www.cell-research.com/arts.asp?id=158 (2016-02-14)
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  • Cell Research
    California Los Angeles Los Angeles CA 90095 1737 USA 2 Eli Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA Los Angleles CA 90095 7357 USA Correspondence Jason Ernst E mail jason ernst ucla edu Histone modifications have previously been leveraged to map the locations of candidate enhancer and promoters in one dimensional genomic space Chepelev et al report the first Chromatin Interaction Analysis with Paired End

    Original URL path: http://www.cell-research.com/arts.asp?id=159 (2016-02-14)
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  • Cell Research
    Sample Issue Submission Advanced Online Publication Current Issue Top 10 VOLUME 22 ISSUE 5 5 2012 791 792 A non coding RNA locus mediates environment conditioned male sterility in rice Danmeng Zhu 1 and Xing Wang Deng 1 2 1 Peking Yale Joint Research Center for Plant Molecular Genetics and Agrobiotechnology State Key Laboratory of Protein and Plant Gene Research College of Life Sciences Peking University Beijing 100871 China 2 Department of Molecular Cellular and Developmental Biology Yale University New Haven Connecticut 06520 USA Correspondence Xing Wang Deng Tel 1 203 432 8908 E mail xingwang deng yale edu The discovery of Nongken 58S a natural recessive photoperiod sensitive male sterile line served as a starting point for development of two line hybrid rice in China While original Nongken 58S in its japonica background is photoperiod sensitive male sterile after introgressing of the related locus into indica rice background the same trait become mainly temperature sensitive male sterile Although those photoperiod and temperature sensitive male sterile lines have been successfully used in two line hybrid rice seed production the genetic cause remained a mystery till the two recent publications with one in Cell Research Cell Research 2012 22 791 792

    Original URL path: http://www.cell-research.com/arts.asp?id=160 (2016-02-14)
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  • Cell Research
    University Hefei Anhui 230032 China Correspondence Kai Simons Tel 49 0 351 210 1200 E mail simons mpi cbg de The polarized distribution of proteins and lipids at the surface membrane of epithelial cells results in the formation of an apical and a basolateral domain which are separated by tight junctions The generation and maintenance of epithelial polarity require elaborate mechanisms that guarantee correct sorting and vectorial delivery of cargo

    Original URL path: http://www.cell-research.com/arts.asp?id=161 (2016-02-14)
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  • Cell Research
    Shenzhen Guangdong 518083 China 3 Life Sciences Division Lawrence Berkeley National Laboratory One Cyclotron Road Berkeley CA 94720 USA 4 Department of Pathology Shanghai Changhai Hospital Second Military Medical University Shanghai 200433 China 5 Department of Urology Jiangsu Provincial People s Hospital Nanjing Medical University Nanjing Jiangsu 210029 China 6 Department of Urology the Third Affiliated Hospital of Sun Yat Sen University Guangzhou Guangdong 510630 China Correspondence Yinghao Sun Tel 86 021 65566429 E mail sunyh medmail com cn There are remarkable disparities among patients of different races with prostate cancer however the mechanism underlying this difference remains unclear Here we present a comprehensive landscape of the transcriptome profiles of 14 primary prostate cancers and their paired normal counterparts from the Chinese population using RNA seq revealing tremendous diversity across prostate cancer transcriptomes with respect to gene fusions long noncoding RNAs long ncRNA alternative splicing and somatic mutations Three of the 14 tumors 21 4 harbored a TMPRSS2 ERG fusion and the low prevalence of this fusion in Chinese patients was further confirmed in an additional tumor set 10 54 18 5 Notably two novel gene fusions CTAGE5 KHDRBS3 20 54 37 and USP9Y TTTY15 19 54 35 2 occurred

    Original URL path: http://www.cell-research.com/arts.asp?id=162 (2016-02-14)
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  • Cell Research
    TX 77030 USA 3 Center for Inflammation and Epigenetics The Methodist Hospital Research Institute Houston TX 77030 USA 4 Department of Pathology and Immunology Baylor College of Medicine Houston TX 77030 USA Correspondence Rong Fu Wang E mail rwang3 tmhs org Nod like receptors NLRs are intracellular sensors that respond to a variety of pathogen and intracellular danger signals to induce innate immune responses NLRC5 has recently been identified to be an important regulator of NF κB type I interferon IFN and inflammasome signaling pathways but the in vivo function and mechanisms of NLRC5 remain to be defined Here we describe the generation and characterization of NLRC5 knockout mice We show that induction of NLRC5 expression by Toll like receptor TLR ligand or cytokine stimulation requires the signal transducers and activators of transcription Stat 1 mediated signaling pathway NLRC5 ablation reduces MHC class I expression and enhances IKK and IRF3 phosphorylation in response to TLR stimulation or viral infection Consistent with these observations we found that NLRC5 deficiency enhanced IL 6 and IFN β production in mouse embryonic fibroblasts MEFs peritoneal macrophages and bone marrow derived macrophages BMMs but not bone marrow derived dendritic cells BMDCs after LPS stimulation or

    Original URL path: http://www.cell-research.com/arts.asp?id=163 (2016-02-14)
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