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  • Cell Research
    Zhong 1 Hanwei Jiang 1 Salma Rasool 1 Qiaomei Hao 1 Zongyou 1 Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences University of Science and Technology of China Hefei Anhui 230026 China 2 Department of Dermatology Brigham and Women s Hospital and Harvard Skin Disease Research Center Harvard Institutes of Medicine Room 664 77 Ave Louis Pasteur Boston MA 02115 USA 3 MRC Human Genetics

    Original URL path: http://www.cell-research.com/arts.asp?id=172 (2016-02-14)
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  • Cell Research
    Publication Current Issue Top 10 VOLUME 22 ISSUE 5 5 2012 936 940 Essential role of Fbxl14 ubiquitin ligase in regulation of vertebrate axis formation through modulating Mkp3 level Hongping Zheng Yong Du Ye Hua Zhili Wu Yuanchang Yan and Yiping Li Hongping Zheng Yong Du Ye Hua Zhili Wu Yuanchang Yan and Yiping Li Correspondence Yiping Li Tel 86 21 54921413 E mail Yipingli sibs ac cn Cell Research

    Original URL path: http://www.cell-research.com/arts.asp?id=173 (2016-02-14)
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  • Cell Research

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    Original URL path: /artsmore1.asp?id=13 (2016-02-14)


  • Cell Research
    Submission Advanced Online Publication Current Issue Top 10 VOLUME 22 ISSUE 6 6 2012 941 944 Reprogramming based gene therapy for inherited red blood cell disorders Xiuling Xu 1 Jing Qu 1 2 Keiichiro Suzuki 2 Mo Li 2 Weizhou Zhang 4 Guang Hui Liu 1 and Juan Carlos Izpisua Belmonte 2 3 1 National Laboratory of Biomacromolecules Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China 2 Gene Expression Laboratory Salk Institute for Biological Studies 10010 North Torrey Pines Road La Jolla CA 92037 USA 3 Center for Regenerative Medicine in Barcelona Dr Aiguader 88 08003 Barcelona Spain 4 Laboratory of Gene Regulation and Signal Transduction Department of Pharmacology School of Medicine University of California San Diego La Jolla CA 92093 USA Correspondence Guang Hui Liu Weizhou Zhang Juan Carlos Izpisua Belmonte E mail ghliu ibp ac cn w4zhang ucsd edu belmonte salk edu izpisua cmrb eu Hematopoietic stem cell transplantation remains the only curative therapy for certain genetic diseases of the hematopoietic system including some inheritable deficiencies in red blood cells RBC Recent advances in induced pluripotent stem cells may open a new era for the cure of such severe genetic RBC diseases Cell Research 2012 22

    Original URL path: http://www.cell-research.com/arts.asp?id=145 (2016-02-14)
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  • Cell Research
    52 121 CHS 10833 Le Conte Ave Los Angeles CA 90095 1750 USA Correspondence Roger S Lo E mail rlo mednet ucla edu The BRAF inhibitors BRAFi induce anti tumor responses in nearly 60 of patients with advanced V600BRAF mutant melanomas but only 5 of patients with V600BRAF mutant colorectal carcinomas Earlier studies of how a subset of melanoma that initially responds to BRAFi but later acquires drug resistance pointed

    Original URL path: http://www.cell-research.com/arts.asp?id=146 (2016-02-14)
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  • Cell Research
    missing Ronald W Stam Department of Pediatric Oncology Haematology Erasmus MC Sophia Children s Hospital Dr Molewaterplein 50 Room Ee15 14a 3015 GE Rotterdam The Netherlands Correspondence Ronald W Stam Tel 31 10 7044654 E mail r stam erasmusmc nl Pre leukemic MLL AF4 fusions arise prenatally and typically lead to overt acute lymphoblastic leukemia ALL at or shortly after birth In a recent study Bueno and colleagues explored the

    Original URL path: http://www.cell-research.com/arts.asp?id=147 (2016-02-14)
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  • Cell Research
    Cell Biology RWTH Aachen University Pauwelsstrasse 30 D 52074 Aachen Germany Correspondence Jürrgen Bernhagen Tel 49 241 8088840 41 E mail jbernhagen ukaachen de Macrophage migration inhibitory factor MIF is overexpressed in numerous tumors and has been correlated with the development of breast cancer but the mechanism s have largely remained unknown Suppression of autophagy has now been unraveled as a pivotal mechanism underlying MIF s role in breast cancer

    Original URL path: http://www.cell-research.com/arts.asp?id=148 (2016-02-14)
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  • Cell Research
    Xing Yu Jiang 2 and Zhen Ge Luo 1 1 Institute of Neuroscience and Key State Laboratory of Neuroscience Chinese Academy of Sciences Shanghai 200031 China 2 National Center for NanoScience and Technology of China Beijing 100190 China Correspondence Zhen Ge Luo E mail zgluo ion ac cn Axon specification during neuronal polarization is closely associated with increased microtubule stabilization in one of the neurites of unpolarized neuron but how this increased microtubule stability is achieved is unclear Here we show that extracellular matrix ECM component laminin promotes neuronal polarization via regulating directional microtubule assembly through β1 integrin Itgb1 Contact with laminin coated on culture substrate or polystyrene beads was sufficient for axon specification of undifferentiated neurites in cultured hippocampal neurons and cortical slices Active Itgb1 was found to be concentrated in laminin contacting neurites Axon formation was promoted and abolished by enhancing and attenuating Itgb1 signaling respectively Interestingly laminin contact promoted plus end microtubule assembly in a manner that required Itgb1 Moreover stabilizing microtubules partially prevented polarization defects caused by Itgb1 downregulation Finally genetic ablation of Itgb1 in dorsal telencephalic progenitors caused deficits in axon development of cortical pyramidal neurons Thus laminin Itgb1 signaling plays an instructive role in

    Original URL path: http://www.cell-research.com/arts.asp?id=149 (2016-02-14)
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