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  • Cell Research
    function Wenqian Hu 1 and Jeff Coller 2 1 Whitehead Institute for Biomedical Research Cambridge MA 02142 USA 2 Center for RNA Molecular Biology Case Western Reserve University Cleveland OH 44106 USA Correspondence Jeff Coller E mail jmc71 case edu While many mechanisms have been proposed for microRNAs miRNAs function most ultimately cause message degradation A view has emerged that miRNAs silence gene expression by promoting the association of mRNA

    Original URL path: http://www.cell-research.com/arts.asp?id=110 (2016-02-14)
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  • Cell Research
    Shin and Akiko Iwasaki Department of Immunobiology Yale University School of Medicine New Haven CT 06520 USA Correspondence Akiko Iwasaki E mail akiko iwasaki yale edu Tissue resident memory T cells TRM are a new subset of memory cells that have been associated with enhanced protective immunity for their tissue of residence A recent study by Jiang et al sheds light on the migration behavior of TRM in both infected

    Original URL path: http://www.cell-research.com/arts.asp?id=111 (2016-02-14)
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  • Cell Research
    1 Qian Zhou 2 Ying Li 2 Haiwei Chen 3 Wen Ye 2 Danying Chen 3 Joy Fleming 1 Hongbing Shu 2 and Yingfang Liu 1 1 State Key Laboratory of Biomacromolecules Institute of Biophysics Chinese Academy of Sciences 15 Datun Road Chaoyang District Beijing 100101 China 2 College of Life Sciences Wuhan University Luojia Hill Wuhan Hubei 430072 China 3 School of Life Sciences Peking University 5 Yi He Yuan Road Haidian Beijing 100871 China Correspondence Yingfang Liu E mail liuy ibp ac cn Interferon stimulated gene 56 ISG56 family members play important roles in blocking viral replication and regulating cellular functions however their underlying molecular mechanisms are largely unclear Here we present the crystal structure of ISG54 an ISG56 family protein with a novel RNA binding structure The structure shows that ISG54 monomers have 9 tetratricopeptide repeat like motifs and associate to form domain swapped dimers The C terminal part folds into a super helical structure and has an extensively positively charged nucleotide binding channel on its inner surface EMSA results show that ISG54 binds specifically to some RNAs such as adenylate uridylate AU rich RNAs with or without 5 triphosphorylation Mutagenesis and functional studies show that this

    Original URL path: http://www.cell-research.com/arts.asp?id=112 (2016-02-14)
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  • Cell Research
    08540 USA 3 Lewis Sigler Institute for Integrative Genomics Princeton University Princeton NJ 08544 USA 4 Genomic Instability and Tumor Progression Program Cancer Institute of New Jersey New Brunswick NJ 08903 USA 5 Current address Department of Human Genetics University of Chicago Chicago IL 60637 USA Correspondence Yibin Kang Tel 01 609 258 8834 E mail ykang princeton edu Bone is the one of the most common sites of distant metastasis of solid tumors Secreted proteins are known to influence pathological interactions between metastatic cancer cells and the bone stroma To comprehensively profile secreted proteins associated with bone metastasis we used quantitative and non quantitative mass spectrometry to globally analyze the secretomes of nine cell lines of varying bone metastatic ability from multiple species and cancer types By comparing the secretomes of parental cells and their bone metastatic derivatives we identified the secreted proteins that were uniquely associated with bone metastasis in these cell lines We then incorporated bioinformatic analyses of large clinical metastasis datasets to obtain a list of candidate novel bone metastasis proteins of several functional classes that were strongly associated with both clinical and experimental bone metastasis Functional validation of selected proteins indicated that in vivo bone

    Original URL path: http://www.cell-research.com/arts.asp?id=113 (2016-02-14)
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  • Cell Research
    Hu 2 and Guohong Hu 1 1 The Key Laboratory of Stem Cell Biology Institute of Health Sciences Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai Jiao Tong University School of Medicine 225 South Chongqing Rd Shanghai 200025 China 2 School of Biomedical Engineering and Med X Research Institute Shanghai Jiao Tong University 1954 Huashan Rd Shanghai 200030 China 3 Anhui Key Laboratory of Cellular Dynamics Chemical Biology University of Science Technology of China Hefei Anhui 230027 China Correspondence Guohong Hu Xiaofang Hu Lisa X Xu Tel 86 21 63844516 E mail ghhu sibs ac cn xfhu sjtu edu cn lisaxu sjtu edu cn Bone metastasis is a frequent complication of breast cancer and a common cause of morbidity and mortality from the disease During metastasis secreted proteins play crucial roles in the interactions between cancer cells and host stroma To characterize the secreted proteins that are associated with breast cancer bone metastasis we preformed a label free proteomic analysis to compare the secretomes of four MDA MB 231 MDA231 derivative cell lines with varied capacities of bone metastasis A total of 128 proteins were found to be consistently up down regulated in the conditioned medium of bone tropic cancer cells The enriched molecular functions of the altered proteins included receptor binding and peptidase inhibition Through additional transcriptomic analyses of breast cancer cells we selected cystatin E M CST6 a cysteine protease inhibitor down regulated in bone metastatic cells for further functional studies Our results showed that CST6 suppressed the proliferation colony formation migration and invasion of breast cancer cells The suppressive function against cancer cell motility was carried out by cancer cell derived soluble CST6 More importantly ectopic expression of CST6 in cancer cells rescued mice from overt osteolytic metastasis and deaths in the animal study while

    Original URL path: http://www.cell-research.com/arts.asp?id=114 (2016-02-14)
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  • Cell Research
    Shanghai Institution of Digestive Disease Key Laboratory of Gastroenterology Hepatology Ministry of Health Shanghai Jiao Tong University State Key Laboratory of Oncogene and Related Genes 145 Middle Shandong Rd Shanghai 200001 China 2 Chinese Academy of Fishery Science Ministry of Agriculture 150 Qingta Yongding Rd Beijing 100141 China 3 Center for Bioinformatics National Laboratory of Protein Engineering and Plant Genetic Engineering College of Life Sciences Peking University 5 Yiheyuan Rd Beijing 100871 China Correspondence Jing Yuan Fang Tel 86 21 53882450 E mail fangjingyuan new 163 com Natural antisense transcripts NATs exist ubiquitously in mammalian genomes and play roles in the regulation of gene expression However both the existence of bidirectional antisense RNA regulation and the possibility of protein coding genes that function as antisense RNAs remain speculative Here we found that the protein coding gene deoxyhypusine synthase DHPS as the NAT of WDR83 concordantly regulated the expression of WDR83 mRNA and protein Conversely WDR83 also regulated DHPS by antisense pairing in a concordant manner WDR83 and DHPS were capable of forming an RNA duplex at overlapping 3 untranslated regions and this duplex increased their mutual stability which was required for the bidirectional regulation As a pair of protein coding

    Original URL path: http://www.cell-research.com/arts.asp?id=115 (2016-02-14)
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  • Cell Research
    State Key Laboratory of Biomembrane and Membrane Bioengineering and The Key Laboratory of Cell Proliferation and Differentiation of Ministry of Education College of Life Sciences Peking University Beijing 100871 China 2 Department of Neurobiology Neuroscience Research Institute School of Basic Medical Sciences Peking University Beijing 100191 China 3 The Center for Theoretical Biology Peking University Beijing 100871 China Correspondence Junlin Teng 86 10 62755786 Tel 86 10 62767044 86 10 62755786 E mail junlinteng pku edu cn chenjg pku edu cn Formation of a bipolar spindle is indispensable for faithful chromosome segregation and cell division Spindle integrity is largely dependent on the centrosome and the microtubule network Centrosome protein Cep57 can bundle microtubules in mammalian cells Its related protein Cep57R in Xenopus was characterized as a stabilization factor for microtubule kinetochore attachment Here we show that Cep57 is a pericentriolar material PCM component Its interaction with NEDD1 is necessary for the centrosome localization of Cep57 Depletion of Cep57 leads to unaligned chromosomes and a multipolar spindle which is induced by PCM fragmentation In the absence of Cep57 centrosome microtubule array assembly activity is weakened and the spindle length and microtubule density decrease As a spindle microtubule binding protein Cep57 is

    Original URL path: http://www.cell-research.com/arts.asp?id=116 (2016-02-14)
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  • Cell Research
    lysine 120 monoubiquitination is required for embryonic stem cell differentiation Su Chen 1 2 3 Juan Li 1 2 Da Liang Wang 3 and Fang Lin Sun 1 2 3 1 School of Life Sciences and Technology Tongji University Shanghai 200092 China 2 The Advanced Institute of Translational Medicine Tongji University Shanghai 200092 China 3 Institute of Epigenetics and Cancer Research School of Medicine Tsinghua University Beijing 100084 China Correspondence

    Original URL path: http://www.cell-research.com/arts.asp?id=117 (2016-02-14)
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