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  • Cell Research
    sites of cell adhesion Xianqiang Song 1 2 Jun Yang 2 Jamila Hirbawi 2 Sheng Ye 1 H Dhanuja Perera 2 Esen Goksoy 2 Pallavi Dwivedi 2 Edward F Plow 2 Rongguang Zhang 1 and J 1 Institute of Biophysics Chinese Academy of Sciences Beijing China 2 Department of Molecular Cardiology Lerner Research Institute Cleveland Clinic 9500 Euclid Ave Cleveland OH 44195 USA Correspondence Jun Qin Rongguang Zhang Tel 1

    Original URL path: http://www.cell-research.com/arts.asp?id=89 (2016-02-14)
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  • Cell Research
    Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences 320 Yue Yang Road Shanghai 200031 China Correspondence Naihe Jing Tel 86 21 54921381 E mail njing sibs ac cn Bone morphogenetic protein BMP inhibits neural specification and induces epidermal differentiation during ectodermal patterning However the mechanism of this process is not well understood Here we show that AP2 γ a transcription factor activator protein AP 2 family member is upregulated by BMP4 during neural differentiation of pluripotent stem cells Knockdown of AP2 γ facilitates mouse embryonic stem cell ESC neural fate determination and impairs epidermal differentiation whereas AP2 γ overexpression inhibits neural conversion and promotes epidermal commitment In the early chick embryo AP2 γ is expressed in the entire epiblast before HH stage 3 and gradually shifts to the putative epidermal ectoderm during HH stage 4 In the future neural plate AP2 γ inhibits excessive neural expansion and it also promotes epidermal development in the surface ectoderm Moreover AP2 γ knockdown in ESCs and chick embryos partially rescued the neural inhibition and epidermal induction effects of BMP4 Mechanistic studies showed that BMP4 directly regulates AP2 γ expression through Smad1 binding to the AP2 γ promoter Taken

    Original URL path: http://www.cell-research.com/arts.asp?id=90 (2016-02-14)
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  • Cell Research
    Membrane Biotechnology and Key Laboratory of Cell Proliferation and Differentiation of Ministry of Education College of Life Sciences Peking University Beijing 100871 China 2 Division of Cancer Research Jacqui Wood Cancer Centre Ninewells Hospital and Medical School University of Dundee DD1 9SY Scotland UK Correspondence Chuanmao Zhang Tel 86 10 62757173 E mail zhangcm pku edu cn The mechanism for nuclear envelope NE assembly is not fully understood Importin β and the small GTPase Ran have been implicated in the spatial regulation of NE assembly process Here we report that chromatin bound NLS nuclear localization sequence proteins provide docking sites for the NE precursor membrane vesicles and nucleoporins via importin α and β during NE assembly in Xenopus egg extracts We show that along with the fast recruitment of the abundant NLS proteins such as nucleoplasmin and histones to the demembranated sperm chromatin in the extracts importin α binds the chromatin NLS proteins rapidly Meanwhile importin β binds cytoplasmic NE precursor membrane vesicles and nucleoporins Through interacting with importin α on the chromatin NLS proteins importin β targets the membrane vesicles and nucleoporins to the chromatin surface Once encountering Ran GTP on the chromatin generated by RCC1 importin β preferentially

    Original URL path: http://www.cell-research.com/arts.asp?id=91 (2016-02-14)
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  • Cell Research
    A M de Haan 4 Johan Neyts 1 Department of Medical Microbiology Virology Section Nijmegen Centre for Molecular Life Sciences Nijmegen Institute for Infection Inflammation and Immunity Radboud University Nijmegen Medical Centre 6500 HB Nijmegen The Netherlands 2 Laboratory of Virology and Chemotherapy Rega Institute for Medical Research University of Leuven B 3000 Leuven Belgium 3 Institut f黵 Pharmazie Abteilung Pharmazeutische Chemie Universit鋞 Innsbruck A 6020 Innsbruck Austria 4 Department of Infectious Diseases and Immunology Virology Division Faculty of Veterinary Medicine Institute of Biomembranes Utrecht University 3508 TD Utrecht The Netherlands Correspondence Frank JM van Kuppeveld Tel 31 24 3617574 E mail f vankuppeveld ncmls ru nl RNA viruses can rapidly mutate and acquire resistance to drugs that directly target viral enzymes which poses serious problems in a clinical context Therefore there is a growing interest in the development of antiviral drugs that target host factors critical for viral replication since they are unlikely to mutate in response to therapy We recently demonstrated that phosphatidylinositol 4 kinase IIIβ PI4KIIIβ and its product phosphatidylinositol 4 phosphate PI4P are essential for replication of enteroviruses a group of medically important RNA viruses including poliovirus PV coxsackievirus rhinovirus and enterovirus 71 Here we show that enviroxime and GW5074 decreased PI4P levels at the Golgi complex by directly inhibiting PI4KIIIβ Coxsackievirus mutants resistant to these inhibitors harbor single point mutations in the non structural protein 3A These 3A mutations did not confer compound resistance by restoring the activity of PI4KIIIβ in the presence of the compounds Instead replication of the mutant viruses no longer depended on PI4KIIIβ since their replication was insensitive to siRNA mediated depletion of PI4KIIIβ The mutant viruses also did not rely on other isoforms of PI4K Consistently no high level of PI4P could be detected at the replication sites induced by

    Original URL path: http://www.cell-research.com/arts.asp?id=92 (2016-02-14)
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  • Cell Research
    Breast Tumor of the 3rd Affiliated Hospital of Kunming Medical University Kunming Yunnan 650118 China 3 Department of Developmental Biology University of Texas Southwestern Medical Center at Dallas Dallas TX 75390 USA Correspondence Yongbin Chen Jin Jiang Tel 86 871 5176312 1 214 645 5914 E mail ybchen mail kiz ac cn jin jiang utsouthwestern edu Hedgehog Hh signaling plays pivotal roles in embryonic development and adult tissue homeostasis in species ranging from Drosophila to mammals The Hh signal is transduced by Smoothened Smo a seven transmembrane protein related to G protein coupled receptors Despite a conserved mechanism by which Hh activates Smo in Drosophila and mammals how mammalian Hh signal is transduced from Smo to the Gli transcription factors is poorly understood Here we provide evidence that two ciliary proteins Evc and Evc2 the products of human disease genes responsible for the Ellis van Creveld syndrome act downstream of Smo to transduce the Hh signal We found that loss of Evc Evc2 does not affect Sonic Hedgehog induced Smo phosphorylation and ciliary localization but impedes Hh pathway activation mediated by constitutively active forms of Smo Evc Evc2 are dispensable for the constitutive Gli activity in Sufu cells suggesting that

    Original URL path: http://www.cell-research.com/arts.asp?id=93 (2016-02-14)
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  • Cell Research
    screening of the human colorectal cancer genome identifies multifunctional tumor suppressors regulating epithelial cell invasion Peter Ly 1 Ugur Eskiocak 1 Chelsea R Parker 1 Kenneth J Harris 1 Woodring E Wright 1 and Jerry W Shay 1 2 1 Department of Cell Biology University of Texas Southwestern Medical Center Dallas TX 75390 USA 2 Center of Excellence in Genomic Medicine Research King Abdulaziz University Jeddah Saudi Arabia Correspondence Jerry

    Original URL path: http://www.cell-research.com/arts.asp?id=94 (2016-02-14)
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  • Cell Research
    extremely enriched in mature mouse sperm Hongying Peng 1 Junchao Shi 1 Ying Zhang 1 He Zhang 1 Shangying Liao 1 Wei Li 1 2 Li Lei 1 2 Chunsheng Han 1 Lina Ning 1 Yujing Cao 1 Qi 1 State Key Laboratory of Reproductive Biology Institute of Zoology Chinese Academy of Sciences Beijing 100101 China 2 Graduate Universty of Chinese Academy of Sciences Beijing 100049 China Correspondence Enkui Duan

    Original URL path: http://www.cell-research.com/arts.asp?id=95 (2016-02-14)
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  • Cell Research
    is mediated by nuclear translocation of the cleaved EIN2 carboxyl terminus Xing Wen 1 Cunli Zhang 1 Yusi Ji 1 Qiong Zhao 1 2 Wenrong He 1 Fengying An 1 Liwen Jiang 2 and Hongwei Guo 1 1 State Key Laboratory of Protein and Plant Gene Research College of Life Sciences Peking Tsinghua Center for Life Sciences Peking University Beijing 100871 China 2 School of Life Sciences the Chinese University

    Original URL path: http://www.cell-research.com/arts.asp?id=96 (2016-02-14)
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