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  • Cell Research

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    Original URL path: /artsmore1.asp?id=147 (2016-02-14)


  • Cell Research
    Institute for Medical Research 1000 E 50th Street Kansas City MO 64110 USA Correspondence Jerry L Workman E mail JLW stowers org An abundance of long non coding RNA lncRNA present in most species from yeast to human are involved in transcriptional regulation dosage compensation and imprinting This underscores the importance of lncRNA as functional RNA despite the fact that they do not produce proteins Two recent papers in Cell

    Original URL path: http://www.cell-research.com/arts.asp?id=1619 (2016-02-14)
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  • Cell Research
    La Jolla CA 92037 USA 2 National Laboratory of Biomacromolecules Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China 3 Center for Regenerative Medicine in Barcelona Dr Aiguader 88 08003 Barcelona Spain Correspondence Guang Hui Liu Juan Carlos Izpisua Belmonte E mail ghliu ibp ac cn belmonte salk edu izpisua cmrb eu Functional human cardiomyocytes hold great promise in cell transplantation based therapy to treat many heart diseases To

    Original URL path: http://www.cell-research.com/arts.asp?id=1620 (2016-02-14)
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  • Cell Research
    NY 10032 USA Correspondence lss5 columbia edu E mail Lorraine S Symington Repair of double strand breaks by homologous recombination requires Repair of double strand breaks by homologous recombination requires 5 3 resection of the DNA ends to create 3 single stranded DNA tails While much progress has been made in identifying the proteins that directly participate in end resection how this process occurs in the context of chromatin is

    Original URL path: http://www.cell-research.com/arts.asp?id=1621 (2016-02-14)
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  • Cell Research
    Søren R Paludan 1 2 1 Department of Biomedicine University of Aarhus Aarhus Denmark 2 Aarhus Research Center for Innate Immunology Aarhus University Aarhus Denmark 3 Department of Infectious Diseases Aarhus University Hospital Skejby Denmark Correspondence Søren R Paludan E mail srp microbiology au dk Human immunodeficiency virus type 1 HIV 1 is the cause of AIDS In recent years it has emerged that cellular interferon stimulated genes ISG play

    Original URL path: http://www.cell-research.com/arts.asp?id=1622 (2016-02-14)
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  • Cell Research
    1 Department of Neuroscience Columbia University Medical Center 630 W 168th St P S 12 403 New York NY 10032 USA 2 Department of Physiology and Cellular Biophysics Columbia University Medical Center 630 W 168th St P S 12 403 New York NY 10032 USA Correspondence Wesley B Grueber E mail wg2135 columbia edu Dendrites exhibit self avoidance in which branches of the same neuron repel each other while overlapping

    Original URL path: http://www.cell-research.com/arts.asp?id=1623 (2016-02-14)
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  • Cell Research
    Department of Cell Biology Harvard Medical School Boston MA 02115 USA Correspondence Yang Shi E mail yshi hms harvard edu Histone lysine demethylases are chromatin modifiers that play important roles in many pathological processes such as inflammation and cancer making them potentially attractive drug targets In a recent study Kruidenier et al provided proof of concept by identifying chemical matters that inhibit demethylation mediated by the two related histone H3

    Original URL path: http://www.cell-research.com/arts.asp?id=1624 (2016-02-14)
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  • Cell Research
    MA 02115 USA 2 Program in Cellular and Molecular Medicine WAB 149G 200 Longwood Av Boston MA 02115 USA 3 Division of Hematology Oncology Department of Pediatrics Boston Children s Hospital WAB 149G 200 Longwood Av Boston MA 02115 USA 4 Department of Genetics Harvard Medical School WAB 149G 200 Longwood Av Boston MA 02115 USA 5 Harvard Stem Cell Institute WAB 149G 200 Longwood Av Boston MA 02115 USA 6 Departments of Bioengineering University of California at San Diego La Jolla CA 92093 0412 USA Correspondence Yi Zhang E mail yzhang genetics med harvard edu Previous studies have revealed that mouse primordial germ cells PGCs undergo genome wide DNA methylation reprogramming to reset the epigenome for totipotency However the precise 5 methylcytosine 5mC dynamics and its relationship with the generation of 5 hydroxymethylcytosine 5hmC are not clear Here we analyzed the dynamics of 5mC and 5hmC during PGC reprograming and germ cell development Unexpectedly we found a specific period E8 5 9 5 during which both 5mC and 5hmC levels are low Subsequently 5hmC levels increase reaching its peak at E11 5 and gradually decrease until E13 5 likely by replication dependent dilution Interestingly 5hmC is enriched in chromocenters during this period While this germ cell specific 5hmC subnuclear localization pattern is maintained in female germ cells even in mature oocytes such pattern is gradually lost in male germ cells as mitotic proliferation resumes during the neonatal stage Pericentric 5hmC plays an important role in silencing major satellite repeat especially in female PGCs Global transcriptome analysis by RNA seq revealed that the great majority of differentially expressed genes from E9 5 to 13 5 are upregulated in both male and female PGCs Although only female PGCs enter meiosis during the prenatal stage meiosis related and a subset of imprinted

    Original URL path: http://www.cell-research.com/arts.asp?id=1625 (2016-02-14)
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