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  • Cell Research
    Laboratory of Molecular Biology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences 320 Yueyang Road Shanghai 200031 China 3 National Center for Protein Science Shanghai 320 Yueyang Road Shanghai 200031 China Correspondence Sandy Chang E mail s chang yale edu Human single strand ss DNA binding proteins 1 and 2 hSSB1 and 2 are components of the hSSB1 2 INTS3 C9orf80 heterotrimeric protein complex shown to participate in DNA damage response and maintenance of genome stability However their roles at telomeres remain unknown Here we generated murine SSB1 conditional knockout mice and cells and found that mSSB1 plays a critical role in telomere end protection Both mSSB1 and mSSB2 localize to a subset of telomeres and are required to repair TRF2 deficient telomeres Deletion of mSSB1 resulted in increased chromatid type fusions involving both leading and lagging strand telomeric DNA suggesting that it is required for the protection of G overhangs mSSB1 s interaction with INTS3 is required for its localization to damaged DNA mSSB1 interacts with Pot1a but not Pot1b and its association with telomeric ssDNA requires Pot1a mSSB1Δ Δ mice die at birth with developmental abnormalities while mice with the hypomorphic

    Original URL path: http://www.cell-research.com/arts.asp?id=1666 (2016-02-14)
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  • Cell Research
    3 Xueguang Zhang 2 Pumin Zhang 4 and Xingxu Huang 1 1 MOE Key Laboratory of Model Animal for Disease Study Model Animal Research Center of Nanjing University Nanjing Biomedical Research Institute National Resource Center for Mutant Mice Nanjing 210061 Jiang Su China 2 Jiangsu Institute of Clinical Immunology The First Affiliated Hospital of Soochow University Suzhou 215007 Jiang Su China 3 Department of Biochemistry and Molecular Biology Tianjin Medical

    Original URL path: http://www.cell-research.com/arts.asp?id=1667 (2016-02-14)
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  • Cell Research
    3 Wooyoung Choi 1 2 3 Yuling Chen 1 2 Qi Zhang 2 Haiteng Deng 1 2 Wei He 2 and Yigong Shi 1 2 3 1 Ministry of Education Key Laboratory of Protein Science School of Life Sciences and School of Medicine Tsinghua University Beijing 100084 China 2 Tsinghua Peking Joint Center for Life Sciences School of Life Sciences and School of Medicine Tsinghua University Beijing 100084 China 3

    Original URL path: http://www.cell-research.com/arts.asp?id=1668 (2016-02-14)
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  • Cell Research
    with meropenem reveals the mechanism of carbapenem against Mycobacterium tuberculosis Wen Juan Li 1 2 De Feng Li 1 Yong Lin Hu 1 Xian En Zhang 1 Li Jun Bi 1 and Da Cheng Wang 1 1 National Laboratory of Biomacromolecules and Laboratory of Noncoding RNA Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China 2 University of the Chinese Academy of Sciences Beijing 100049 China Correspondence Li Jun

    Original URL path: http://www.cell-research.com/arts.asp?id=1669 (2016-02-14)
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  • Cell Research
    732 732 RNA seq analysis of prostate cancer in the Chinese population identifies recurrent gene fusions cancer associated long noncoding RNAs and aberrant alternative splicings Shancheng Ren Zhiyu Peng Jian Hua Mao Yongwei Yu Changjun Yin Xin Gao Zilian Cui Jibin Zhang Kang Yi Weidong Xu Chao Chen Fubo Wang Xinwu Guo Ji Lu Jun Yang Min Wei Zhijian Tian Yinghui Guan Liang Tang Chuanliang Xu Linhui Wang Xu Gao

    Original URL path: http://www.cell-research.com/arts.asp?id=1670 (2016-02-14)
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  • Cell Research

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    Original URL path: /artsmore1.asp?id=156 (2016-02-14)


  • Cell Research
    Dangé Saint Romain 86220 France 2 DuPont Nutrition and Health Madison WI 53716 USA 3 New address Department of Food Bioprocessing and Nutrition Sciences North Carolina State University Raleigh NC 27695 USA Correspondence Philippe Horvath Tel 33 549 191 209 Fax 33 549 864 839 E mail philippe horvath dupont com Two recent papers in Science illustrate how the prokaryotic CRISPR Cas immune system machinery which typically targets invasive genetic

    Original URL path: http://www.cell-research.com/arts.asp?id=1758 (2016-02-14)
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  • Cell Research
    of Biological Chemistry and Molecular Pharmacology Harvard Medical School Boston MA 02115 USA 2 Program in Cellular and Molecular Medicine Boston Children s Hospital Boston MA 02115 USA Correspondence Sun Hur E mail hur idi harvard edu Paramyxoviruses evade antiviral immune response using a small nonstructural protein V which binds to the host dsRNA sensor MDA5 and prevents it from activating the interferon signaling pathway A recent crystal structure of

    Original URL path: http://www.cell-research.com/arts.asp?id=1759 (2016-02-14)
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