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  • Cell Research
    Academy of Sciences Beijing 100101 China 3 Tsinghua Peking Center for Life Sciences Tsinghua University Beijing 100084 China Correspondence Zhi Xin Wang Tel 86 10 6278 5505 Fax 86 10 6279 2826 E mail zhixinwang mail tsinghua edu cn Jia Wei Wu Tel 86 10 6278 9387 Fax 86 10 6279 2826 E mail jiaweiwu mail tsinghua edu cn The Ca2 calmodulin dependent protein phosphatase calcineurin CN a heterodimer composed of a catalytic subunit A and an essential regulatory subunit B plays critical functions in various cellular processes such as cardiac hypertrophy and T cell activation It is the target of the most widely used immunosuppressants for transplantation tacrolimus FK506 and cyclosporin A However the structure of a large part of the CNA regulatory region remains to be determined and there has been considerable debate concerning the regulation of CN activity Here we report the crystal structure of full length CN β isoform which revealed a novel autoinhibitory segment AIS in addition to the well known autoinhibitory domain AID The AIS nestles in a hydrophobic intersubunit groove which overlaps the recognition site for substrates and immunosuppressant immunophilin complexes Indeed disruption of this AIS interaction results in partial stimulation of CN

    Original URL path: http://www.cell-research.com/aoparts.asp?id=463 (2016-02-14)
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  • Cell Research
    USA 5 Cores of Integrative Genomics City of Hope Beckman Research Institute and Medical Center Duarte CA 91010 USA 6 City of Hope Irell Manella Graduate School of Biological Sciences Duarte CA 91010 USA Correspondence Shizhen Emily Wang E mail ewang coh org MicroRNAs miRNAs are critical regulators of gene expression and exert extensive impacts on development physiology and disease of eukaryotes A high degree of parallelism is found in the molecular basis of miRNA biogenesis and action in plants and animals Recent studies interestingly suggest a potential cross kingdom action of plant derived miRNAs through dietary intake in regulating mammalian gene expression Although the source and scope of plant miRNAs detected in mammalian specimens remain controversial these initial studies inspired us to determine whether plant miRNAs can be detected in Western human sera and whether these plant miRNAs are able to influence gene expression and cellular processes related to human diseases such as cancer Here we found that Western donor sera contained the plant miRNA miR159 whose abundance in the serum was inversely correlated with breast cancer incidence and progression in patients In human sera miR159 was predominantly detected in the extracellular vesicles and was resistant to sodium periodate

    Original URL path: http://www.cell-research.com/aoparts.asp?id=462 (2016-02-14)
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  • Cell Research
    Biology Laboratory Institutes of Biomedical Sciences Shanghai Medical College Fudan University Shanghai 200032 China 2 Department of Pharmacology and Moores Cancer Center University of California San Diego La Jolla CA 92093 USA Correspondence Hai Xin Yuan E mail yuanhaixin fudan edu cn Kun Liang Guan E mail kuguan ucsd edu The mammalian target of rapamycin mTOR also known as the mechanistic target of rapamycin is a central cell growth regulating

    Original URL path: http://www.cell-research.com/aoparts.asp?id=461 (2016-02-14)
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  • Cell Research
    and Juan Carlos Izpisua Belmonte 1 1 Gene Expression Laboratory The Salk Institute for Biological Studies 10010 North Torrey Pines Road La Jolla CA 92037 USA Correspondence Juan Carlos Izpisua Belmonte Tel 1 858 453 4100 ext 1130 E mail belmonte salk edu Reprogramming to pluripotency has thus far required complex procedures involving nuclear transfer cell fusion or genetic manipulation Two recent papers from Hongkui Deng s group now show

    Original URL path: http://www.cell-research.com/aoparts.asp?id=460 (2016-02-14)
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  • Cell Research
    Recherche Médicale Unité 1138 Paris F 75006 France 2 Sorbonne Universités UPMC Univ Paris 06 UMR S 1138 Paris F 75006 France 3 Université Paris Descartes Sorbonne Paris Cité UMR S 1138 Paris F 75006 France 4 Centre de Recherche des Cordeliers Equipe Immunopathologie et immuno intervention thérapeutique Paris F 75006 France Correspondence Jagadeesh Bayry E mail jagadeesh bayry crc jussieu fr IgE is commonly known for its role in

    Original URL path: http://www.cell-research.com/aoparts.asp?id=459 (2016-02-14)
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  • Cell Research
    SIRT6 oxidative stress and aging FREE Chen Yu Liao 1 and Brian K Kennedy 1 1 Buck Institute for Research on Aging 8001 Redwood Blvd Novato CA 94945 USA Correspondence Brian K Kennedy Tel 415 209 2040 E mail bkennedy buckinstitute org The role of oxidative stress in the aging process has been highly debated for decades and remains equivocal A new study published in Cell Research reports a novel

    Original URL path: http://www.cell-research.com/aoparts.asp?id=458 (2016-02-14)
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  • Cell Research
    labeling OPEN Albert W Cheng 1 2 3 Nathaniel Jillette 1 2 Phoebe Lee 1 Dylan Plaskon 1 Yasuhiro Fujiwara 1 Wenbo Wang 1 Aziz Taghbalout 2 and Haoyi Wang 1 4 1 The Jackson Laboratory Bar Harbor ME 04609 USA 2 The Jackson Laboratory for Genomic Medicine Farmington CT 06032 USA 3 Department of Genetics and Genome Sciences University of Connecticut School of Medicine Farmington CT 06030 USA 4 State Key Laboratory of Stem Cell and Reproductive Biology Institute of Zoology Chinese Academy of Sciences Beijing 100101 China Correspondence Haoyi Wang E mail wanghaoyi ioz ac cn Albert W Cheng E mail albert cheng jax org The CRISPR Cas9 system has recently been widely adopted in genome editing due to its simplicity1 2 3 Nuclease deficient mutant dCas9 protein can be fused to effector domains and the fusion proteins can be guided by sgRNAs to genomic sites to regulate gene expression or label chromosomes4 5 6 7 8 9 10 However only one type of effector is applied in most experiments due to the exclusive sgRNA Cas9 pairing Moreover multimerization by directly fusing multiple copies of effectors with dCas9 protein to achieve sufficient effector activity is technically challenging RNA

    Original URL path: http://www.cell-research.com/aoparts.asp?id=457 (2016-02-14)
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  • Cell Research
    G Netea 1 and Leo AB Joosten 1 1 Department of Internal Medicine and Radboud Center for Infectious Diseases RCI Radboud University Medical Center Nijmegen The Netherlands Correspondence E mail mihai netea radboudumc nl Leo AB Joosten E mail leo joosten radboudumc nl Macrophages are important innate immune cells with functions in tissue repair and remodeling induction and resolution of inflammation as well as elimination of invading pathogens In a

    Original URL path: http://www.cell-research.com/aoparts.asp?id=453 (2016-02-14)
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