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  • Cell Research
    and Ari M Melnick 1 2 1 Department of Medicine Division of Hematology Oncology Weill Cornell Medical College 1300 York Ave New York NY 10065 USA 2 Department of Pharmacology Weill Cornell Medical College 1300 York Ave New York NY 10065 USA E mail amm2014 med cornell edu Recently discovered recurrent somatic mutations in the key metabolic enzymes IDH1 and IDH2 produce the aberrant oncometabolite 2 HG and contribute to

    Original URL path: http://www.cell-research.com/arts.asp?id=1794 (2016-02-14)
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  • Cell Research
    Kyohei Oyama 1 Danny El Nachef 1 and W Robb MacLellan 1 1 Departments of Medicine and Cardiology Center for Cardiovascular Biology Institute for Stem Cell Research University of Washington School of Medicine Seattle WA 98195 USA Correspondence W Robb MacLellan Tel 1 206 543 8584 Fax 1 206 616 4847 E mail WRMacLellan cardiology washington edu Although adult cardiac myocytes CMs have very little proliferative potential fetal CMs divide

    Original URL path: http://www.cell-research.com/arts.asp?id=1795 (2016-02-14)
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  • Cell Research
    Harvard Medical School Boston MA 02114 USA 2 The Broad Institute of Harvard and MIT Cambridge MA 02142 USA 3 INSERM U1065 Centre Méditerranéen de Médecine Moléculaire C3M Toxines Microbiennes dans la relation hôte pathogènes Nice F 06204 France Correspondence Lynda M Stuart E mail lstuart partners org A recent study published in Nature by Keestra and colleagues addresses how the immune system detects the pathogenic potential of microbes and

    Original URL path: http://www.cell-research.com/arts.asp?id=1796 (2016-02-14)
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  • Cell Research
    1 Molecular Cancer Research Centre for Biomedical Genetics and Cancer Genomics Centre University Medical Center Utrecht Universiteitsweg 100 3584 CG Utrecht The Netherlands Correspondence Fried J T Zwartkruis E mail G J T Zwartkruis umcutrecht nl Boudewijn M T Burgering E mail B M T Burgering umcutrecht nl Oncogene driven adaptation of metabolism during tumorigenesis includes steps that stimulate the uptake of nutrients especially glucose and glutamine to sustain cell

    Original URL path: http://www.cell-research.com/arts.asp?id=1797 (2016-02-14)
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  • Cell Research
    Byles 1 and Tiffany Horng 1 1 Department of Genetics and Complex Diseases Harvard School of Public Health Boston MA 02115 USA Correspondence Correspondence Tiffany Horng E mail thorng hsph harvard edu While M1 macrophages are highly pro inflammatory and microbicidal M2 macrophages and the related tumor associated macrophages TAMs regulate tissue remodeling and angiogenesis and can display immunomodulatory activity In July issue of Cell Research Zhang et al show

    Original URL path: http://www.cell-research.com/arts.asp?id=1798 (2016-02-14)
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  • Cell Research
    2 Ying Hua Chen 1 Linqi Zhang 2 and Xinquan Wang 1 1 Ministry of Education Key Laboratory of Protein Science Center for Structural Biology School of Life Sciences Tsinghua University Beijing 100084 China 2 Comprehensive AIDS Research Center Research Center for Public Health School of Medicine Tsinghua University Beijing 100084 China Correspondence Correspondence Xinquan Wang E mail xinquanwang mail tsinghua edu cn Linqi Zhang E mail zhanglinqi tsinghua edu cn These two authors contributed equally to this work The spike glycoprotein S of recently identified Middle East respiratory syndrome coronavirus MERS CoV targets the cellular receptor dipeptidyl peptidase 4 DPP4 Sequence comparison and modeling analysis have revealed a putative receptor binding domain RBD on the viral spike which mediates this interaction We report the 3 0 Å resolution crystal structure of MERS CoV RBD bound to the extracellular domain of human DPP4 Our results show that MERS CoV RBD consists of a core and a receptor binding subdomain The receptor binding subdomain interacts with DPP4 β propeller but not its intrinsic hydrolase domain MERS CoV RBD and related SARS CoV RBD share a high degree of structural similarity in their core subdomains but are notably divergent in the receptor

    Original URL path: http://www.cell-research.com/arts.asp?id=1799 (2016-02-14)
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  • Cell Research
    He 1 Yangxin Li 1 Jianhui Ma 1 Wanze Chen 1 Yingying Zhang 1 Xiaojuan Zhou 1 Zhentao Yang 1 Su Qin Wu 1 Lanfen Chen 1 and Jiahuai Han 1 1 State Key Laboratory of Cellular Stress Biology and School of Life Sciences Xiamen University Xiamen Fujian 361005 China Correspondence Correspondence Jiahuai Han E mail jhan xmu edu cn jhan scripps edu These three authors contributed equally to this work Mixed lineage kinase domain like protein Mlkl was recently found to interact with receptor interacting protein 3 Rip3 and to be essential for tumor necrosis factor TNF induced programmed necrosis necroptosis in cultured cell lines We have generated Mlkl deficient mice by transcription activator like effector nucleases TALENs mediated gene disruption and found Mlkl to be dispensable for normal mouse development as well as immune cell development Mlkl deficient mouse embryonic fibroblasts MEFs and macrophages both showed resistance to necrotic but not apoptotic stimuli Mlkl deficient MEFs and macrophages were indistinguishable from wild type cells in their ability to activate NF κB ERK JNK and p38 in response to TNF and lipopolysaccharides LPS respectively Consistently Mlkl deficient macrophages and mice exhibited normal interleukin 1β IL 1β IL 6 and

    Original URL path: http://www.cell-research.com/arts.asp?id=1800 (2016-02-14)
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  • Cell Research
    1 Ming Zhu 1 Ying Xiong 1 Qin Li 1 Catherine CY Chang 2 Bao Liang Song 1 Ta Yuan Chang 2 and Bo Liang Li 1 1 State Key Laboratory of Molecular Biology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China 2 Department of Biochemistry Geisel School of Medicine at Dartmouth Hanover NH 03756 USA Correspondence Correspondence Bo Liang Li Tel 86 21 54921278 Fax 86 21 54921279 E mail blli sibcb ac cn These three authors contributed equally to this work Trans splicing a process involving the cleavage and joining of two separate transcripts can expand the transcriptome and proteome in eukaryotes Chimeric RNAs generated by trans splicing are increasingly described in literatures The widespread presence of antibiotic resistance genes in natural environments and human intestines is becoming an important challenge for public health Certain antibiotic resistance genes such as ampicillin resistance gene Ampr are frequently used in recombinant plasmids Until now trans splicing involving recombinant plasmid derived exogenous transcripts and endogenous cellular RNAs has not been reported Acyl CoA cholesterol acyltransferase 1 ACAT1 is a key enzyme involved in cellular cholesterol homeostasis The 4 3 kb human ACAT1 chimeric mRNA can produce 50 kDa and 56 kDa isoforms with different enzymatic activities Here we show that human ACAT1 56 kDa isoform is produced from an mRNA species generated through the trans splicing of an exogenous transcript encoded by the antisense strand of Ampr asAmp present in common Ampr plasmids and the 4 3 kb endogenous ACAT1 chimeric mRNA which is presumably processed through a prior event of interchromosomal trans splicing Strikingly DNA fragments containing the asAmp with an upstream recombined cryptic promoter and the corresponding exogenous asAmp transcripts have been detected in human cells Our findings shed

    Original URL path: http://www.cell-research.com/arts.asp?id=1801 (2016-02-14)
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