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  • Cell Research
    of Biological Geological and Environmental Sciences College of Sciences and Health Professions Cleveland State University 2121 Euclid Avenue Cleveland OH 44115 USA 2 Department of Molecular Genetics Lerner Research Institute of the Cleveland Clinic 9500 Euclid Avenue Cleveland OH 44195 USA Correspondence Sailen Barik Tel 1 216 523 7326 Fax 1 216 687 6972 E mail s barik csuohio edu The balance between the innate immunity of the host and the ability of a pathogen to evade it strongly influences pathogenesis and virulence The two nonstructural NS proteins NS1 and NS2 of respiratory syncytial virus RSV are critically required for RSV virulence Together they strongly suppress the type I interferon IFN mediated innate immunity of the host cells by degrading or inhibiting multiple cellular factors required for either IFN induction or response pathways including RIG I IRF3 IRF7 TBK1 and STAT2 Here we provide evidence for the existence of a large and heterogeneous degradative complex assembled by the NS proteins which we named NS degradasome NSD The NSD is roughly 300 750 kD in size and its degradative activity was enhanced by the addition of purified mitochondria in vitro Inside the cell the majority of the NS proteins and the

    Original URL path: http://www.cell-research.com/arts.asp?id=1805 (2016-02-14)
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  • Cell Research
    200032 China 2 VARI SIMM Center Center for Structure and Function of Drug Targets Key Laboratory of Receptor Research Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201203 China 3 Institute of Chemical Biology Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences No 190 Kaiyuan Avenue Guangzhou Science Park Guangzhou Guangdong 510530 China 4 Shenyang Pharmaceutical University No 103 Wenhua Road Shenhe District Shenyang Liaoning 110016 China 5 Laboratory of Structural Sciences Center for Structural Biology and Drug Discovery Van Andel Research Institute 333 Bostwick Ave N E Grand Rapids MI 49503 USA 6 Department of Horticulture and Landscape Architecture Purdue University West Lafayette IN 47906 USA 7 Shanghai Institute of Plant Physiology and Ecology Shanghai Institutes of Biological Sciences Chinese Academy of Sciences 300 Fenglin Road Shanghai 200032 China 8 Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201203 China Correspondence Correspondence Jian Kang Zhu E mail zhu132 purdue edu H Eric Xu E mail Eric Xu vai org Yong Xu E mail xu yong gibh ac cn These two authors contributed equally to this work Abscisic acid ABA is the most important hormone for plants to resist drought and other abiotic stresses ABA binds directly to the PYR PYL family of ABA receptors resulting in inhibition of type 2C phosphatases PP2C and activation of downstream ABA signaling It is envisioned that intervention of ABA signaling by small molecules could help plants to overcome abiotic stresses such as drought cold and soil salinity However chemical instability and rapid catabolism by plant enzymes limit the practical application of ABA itself Here we report the identification of a small molecule ABA mimic AM1 that acts as a potent activator of multiple members of the family of ABA receptors In Arabidopsis AM1 activates a gene network

    Original URL path: http://www.cell-research.com/arts.asp?id=1802 (2016-02-14)
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  • Cell Research
    Crowley3 Zongyang Lv 1 Jingjing Li 1 Yingfang Liu 1 Genhong Cheng 3 Su Zeng 2 and Huanhuan Liang 1 1 State Key Laboratory of Biomacromolecules Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China 2 Department of Pharmaceutical Analysis and Drug Metabolism Zhejiang University Hangzhou Zhejiang 310058 China 3 Department of Microbiology Immunology and Molecular Genetics University of California Los Angeles CA 90095 USA Correspondence Huanhuan Liang E

    Original URL path: http://www.cell-research.com/arts.asp?id=1803 (2016-02-14)
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  • Cell Research
    Liu 1 Peng Li 1 Duanqing Pei 1 and Liangxue Lai 1 2 1 Key Laboratory of Regenerative Biology Chinese Academy of Sciences Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine South China Institute for Stem Cell Biology and Regenerative Medicine Guangzhou Institutes of Biomedicine and Health Guangzhou Guangdong 510530 China 2 College of Veterinary Medicine Jilin University Changchun Jilin 130062 China 3 School of Life Sciences University of Science and Technology of China Hefei Anhui 230027 China Correspondence Duanqing Pei E mail pei duanqing gibh ac cn Liangxue Lai E mail lai liangxue gibh ac cn These three authors contributed equally to this work The traditional approach for the generation of gene targeted animals is homologous recombination HR conducted in embryonic stem ES cells followed by chimera technology such as in mice and rats or HR in somatic cells combined with nuclear transfer in those animals in which germline competent ES cells are not available such as pigs sheep goats and cattle However no germline competent rabbit ES cells are yet available Furthermore the efficiency of rabbit cloning is so low that no gene targeted rabbits have been produced thus far by somatic cell nuclear transfer approaches Over the past several years zinc finger nucleases ZFNs technology has been employed to produce gene knockout KO animals such as rats1 pigs2 and rabbits3 Recently transcription activator like effector nucleases TALENs a new genome modifying technology has been employed for in vivo genetic engineering in vertebrates Unlike ZFNs TALENs have fewer off target effects and lower toxicity Given the success of the TALEN technology in reported species 4 5 6 we attempted to explore the feasibility of producing KO rabbits using this technology In the current study we chose recombination activation genes RAGs including RAG1 and RAG2 as the

    Original URL path: http://www.cell-research.com/arts.asp?id=1804 (2016-02-14)
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  • Cell Research

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    Original URL path: /artsmore1.asp?id=159 (2016-02-14)


  • Cell Research
    VOLUME 23 ISSUE 9 9 2013 1063 1064 The mysterious origins of coronary vessels FREE Bing Zhang 1 and William T Pu 1 2 1 Department of Cardiology Boston Children s Hospital Boston MA 02115 USA 2 Harvard Stem Cell Institute Harvard University Cambridge MA 02138 USA Correspondence Correspondence William T Pu wpu pulab org The origin of the coronary vessels remains a mystery Here we review recent studies that

    Original URL path: http://www.cell-research.com/arts.asp?id=1806 (2016-02-14)
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  • Cell Research
    Fagundes 1 and Luke A J O Neill 1 1 School of Biochemistry and Immunology Trinity Biomedical Sciences Institute Trinity College Dublin Dublin 2 Ireland Correspondence Luke A J O Neill Tel 353 1 896 1851 E mail laoneill tcd ie A cyclic dinucleotide comprised of GMP and AMP was previously shown to be a key intermediate during activation of innate immune responses to cytosolic DNA A report by Patel

    Original URL path: http://www.cell-research.com/arts.asp?id=1807 (2016-02-14)
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  • Cell Research
    Polina Kornilov 1 Asher Peretz 1 and Bernard Attali 1 1 Department of Physiology Pharmacology Sackler Faculty of Medicine Tel Aviv University Tel Aviv 69978 Israel Correspondence Correspondence Bernard Attali Tel 972 3640 5116 Fax 972 3640 9113 E mail battali post tau ac il Each subunit of voltage gated cation channels comprises a voltage sensing domain and a pore region In a paper recently published in Cell Research Li

    Original URL path: http://www.cell-research.com/arts.asp?id=1808 (2016-02-14)
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