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  • Cell Research
    Stalin Raj 2 and Bart L Haagmans 2 1 Virology Division Department of Infectious Diseases Immunology Faculty of Veterinary Medicine Utrecht University 3508 TD Utrecht the Netherlands 2 Department of Viroscience Erasmus Medical Center 3000 CA Rotterdam the Netherlands Correspondence Bart L Haagmans E mail b haagmans erasmusmc nl A novel coronavirus the Middle East respiratory syndrome coronavirus recently emerged through zoonotic transmission causing a severe lower respiratory tract infection

    Original URL path: http://www.cell-research.com/arts.asp?id=1809 (2016-02-14)
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  • Cell Research
    way to link FREE Christian Preußer 1 and Albrecht Bindereif 1 1 Institute of Biochemistry Justus Liebig University of Giessen D 35392 Giessen Germany Correspondence Albrecht Bindereif Tel 49 641 9935 420 Fax 49 641 9935 419 E mail albrecht bindereif chemie bio uni giessen de In addition to canonical cis splicing which joins exons from a single pre mRNA various forms of trans splicing have been described whereby two

    Original URL path: http://www.cell-research.com/arts.asp?id=1816 (2016-02-14)
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  • Cell Research
    2 1 Department of Neurology Mount Sinai School of Medicine 1468 Madison Avenue Annenberg Building Room 20 02 New York NY 10029 USA 2 GRECC James J Peters Veterans Affairs Medical Center Bronx NY USA Correspondence Giulio Maria Pasinetti Tel 1 212 241 7938 or 1 212 241 5563 Fax 1 212 876 9042 E mail Giulio Pasinetti mssm edu Sirtuins have received a lot of attention in biological functions

    Original URL path: http://www.cell-research.com/arts.asp?id=1817 (2016-02-14)
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  • Cell Research
    Biological Sciences Graduate School of the Chinese Academy of Sciences Chinese Academy of Sciences Shanghai 200031 China 2 Model Animal Research Center of Nanjing University Nanjing Jiangsu 210061 China 3 Shanghai Children s Medical Center Shanghai Jiao Tong University School of Medicine Shanghai 200092 China 4 State Key Laboratory of Genetic Engineering School of Life Sciences Fudan University Shanghai 200433 China 5 State Key Laboratory of Proteomics Institute of Biotechnology Beijing 100071 China 6 Zhongshan Hospital Fudan University Shanghai 200032 China 7 Institute of Genetics and Biophysics CNR University of Naples Federico II 80138 Naples Italy 8 School of Medicine Tongji University Shanghai 201000 China 9 Shanghai 10th People s Hospital Tongji University School of Medicine Shanghai 200072 China 10 Department of Biology and Biochemistry University of Houston Houston TX 77204 USA 11 The Skaggs School of Pharmacy and Pharmaceutical Science University of California San Diego La Jolla CA 92093 USA 12 Department of Cardiology Leiden University Medical Center Postal zone S 5 24 PO Box 9600 2300 RC Leiden The Netherlands 13 Department of Biology School of Medicine Stanford University Stanford CA 94305 USA Correspondence Bin Zhou E mail zhoubin sibs ac cn Coronary arteries bring blood flow to the heart muscle Understanding the developmental program of the coronary arteries provides insights into the treatment of coronary artery diseases Multiple sources have been described as contributing to coronary arteries including the proepicardium sinus venosus SV and endocardium However the developmental origins of coronary vessels are still under intense study We have produced a new genetic tool for studying coronary development an AplnCreER mouse line which expresses an inducible Cre recombinase specifically in developing coronary vessels Quantitative analysis of coronary development and timed induction of AplnCreER fate tracing showed that the progenies of subepicardial endothelial cells ECs both invade the

    Original URL path: http://www.cell-research.com/arts.asp?id=1810 (2016-02-14)
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  • Cell Research
    Gao 1 Hualiang Jiang 2 and Min Li 1 3 1 CAS Key Laboratory of Receptor Research Shanghai Institute of Materia Medica Chinese Academy of Sciences 555 Zuchongzhi Road Shanghai 201203 China 2 State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences 555 Zuchongzhi Road Shanghai 201203 China 3 The Solomon H Snyder Department of Neuroscience High Throughput Biology Center and Johns Hopkins Ion Channel Center School of Medicine Johns Hopkins University Baltimore MD 21205 USA Correspondence Hualiang Jiang 86 21 50805873 Fax 86 21 50807088 E mail hljiang mail shcnc ac cn Zhaobing Gao Tel 86 21 20239067 Fax 86 21 20239067 E mail zbgao simm ac cn Huaiyu Yang Tel 86 21 50800619 Fax 86 21 50807088 E mail hyyang simm ac cn Voltage gated potassium Kv channels derive their voltage sensitivity from movement of gating charges in voltage sensor domains VSDs The gating charges translocate through a physical pathway in the VSD to open or close the channel Previous studies showed that the gating charge pathways of Shaker and Kv1 2 2 1 chimeric channels are occluded forming the structural basis for the focused electric field and gating charge transfer center Here we show that the gating charge pathway of the voltage gated KCNQ2 potassium channel activity reduction of which causes epilepsy can accommodate various small molecule ligands Combining mutagenesis molecular simulation and electrophysiological recording a binding model for the probe activator ztz240 in the gating charge pathway was defined This information was used to establish a docking based virtual screening assay targeting the defined ligand binding pocket Nine activators with five new chemotypes were identified and in vivo experiments showed that three ligands binding to the gating charge pathway exhibit significant anti epilepsy activity Identification of various novel activators by

    Original URL path: http://www.cell-research.com/arts.asp?id=1812 (2016-02-14)
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  • Cell Research
    School of Medicine SJTUSM Shanghai 200025 China 2 Shanghai Stem Cell Institute Shanghai Jiao Tong University School of Medicine SJTUSM Shanghai 200025 China Correspondence Huang Tian Yang Tel Fax 86 21 63852593 E mail htyang sibs ac cn Cardiovascular progenitor cells CVPCs derived from human pluripotent stem cells hPSCs including human embryonic stem cells hESCs and human induced pluripotent stem cells hiPSCs hold great promise for the study of cardiovascular development and cell based therapy of heart diseases but their applications are challenged by the difficulties in their efficient generation and stable maintenance This study aims to develop chemically defined systems for robust generation and stable propagation of hPSC derived CVPCs by modulating the key early developmental pathways involved in human cardiovascular specification and CVPC self renewal Herein we report that a combination of bone morphogenetic protein 4 BMP4 glycogen synthase kinase 3 GSK3 inhibitor CHIR99021 and ascorbic acid is sufficient to rapidly convert monolayer cultured hPSCs including hESCs and hiPSCs into homogeneous CVPCs in a chemically defined medium under feeder and serum free culture conditions These CVPCs stably self renewed under feeder and serum free conditions and expanded over 107 fold when the differentiation inducing signals from BMP GSK3

    Original URL path: http://www.cell-research.com/arts.asp?id=1813 (2016-02-14)
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  • Cell Research
    and Human Disease Mechanisms of Chinese Academy of Sciences Yunnan Province Kunming Institute of Zoology Chinese Academy of Sciences 32 Jiaochang Donglu Kunming Yunnan 650223 China 3 Program in Molecular Medicine University of Massachusetts Medical School Worcester MA 01605 USA 4 Current address Wuxi AppTec Wuxi Jiangsu 214092 China 5 Current address Department of Biochemistry and Cell Biology Rice University Houston TX 77251 USA Correspondence Jin Jiang E mail Jin Jiang utsouthwestern edu Intestinal stem cells ISCs in the Drosophila adult midgut are essential for maintaining tissue homeostasis and their proliferation and differentiation speed up in order to meet the demand for replenishing the lost cells in response to injury Several signaling pathways including JAK STAT EGFR and Hippo Hpo pathways have been implicated in damage induced ISC proliferation but the mechanisms that integrate these pathways have remained elusive Here we demonstrate that the Drosophila homolog of the oncoprotein Myc dMyc functions downstream of these signaling pathways to mediate their effects on ISC proliferation dMyc expression in precursor cells is stimulated in response to tissue damage and dMyc is essential for accelerated ISC proliferation and midgut regeneration We show that tissue damage caused by dextran sulfate sodium feeding stimulates dMyc

    Original URL path: http://www.cell-research.com/arts.asp?id=1814 (2016-02-14)
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  • Cell Research
    2013 1147 1149 Establishing brain functional laterality in adult mice through unilateral gene manipulation in the embryonic cortex Qingsong Li 1 3 Shan Bian 1 Bingfang Liu 2 Janet Hong 1 Miklos Toth 2 and Tao Sun 1 1 Department of Cell and Developmental Biology Cornell University Weill Medical College 1300 York Avenue New York NY 10065 USA 2 Department of Pharmacology Cornell University Weill Medical College 1300 York Avenue

    Original URL path: http://www.cell-research.com/arts.asp?id=1815 (2016-02-14)
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