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  • Cell Research

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    Original URL path: /artsmore1.asp?id=160 (2016-02-14)



  • Cell Research
    2 Nicolas Léveillé 1 and Reuven Agami 1 3 1 Division of Gene Regulation The Netherlands Cancer Institute Plesmanlaan 121 1066 CX Amsterdam The Netherlands 2 Doctoral Programme in Biomedicine and Experimental Biology Centre for Neuroscience and Cell Biology Erasmus MC Rotterdam University The Netherlands 3 Erasmus MC Rotterdam University The Netherlands Correspondence Reuven Agami E mail r agami nki nl Recently various studies shed light on the functional significance

    Original URL path: http://www.cell-research.com/arts.asp?id=1818 (2016-02-14)
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  • Cell Research
    way FREE Fu Huang 1 and Jerry L Workman 1 1 Stowers Institute for Medical Research 1000 East 50th Street Kansas City MO 64110 USA Correspondence Jerry L Workman E mail jlw stowers org How cells ensure that productive transcription from divergent promoters is limited to the downstream protein coding region is an important question in the transcription field A recent study in Nature proposed an answer by revealing that

    Original URL path: http://www.cell-research.com/arts.asp?id=1819 (2016-02-14)
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  • Cell Research
    out for tumor suppression FREE Antonella Papa 1 Ming Chen 1 and Pier Paolo Pandolfi 1 1 Cancer Genetics Program Beth Israel Deaconess Cancer Center Departments of Medicine and Pathology Beth Israel Deaconess Medical Center Harvard Medical School Boston MA 02115 USA Correspondence Pier Paolo Pandolfi E mail ppandolf bidmc harvard edu The tumor suppressive activity of PTEN has always been attributed to its endogenous intracellular function Recently two different

    Original URL path: http://www.cell-research.com/arts.asp?id=1820 (2016-02-14)
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  • Cell Research
    The University of Texas MD Anderson Cancer Center 1515 Holcombe Boulevard Houston TX 77030 USA 2 Department of Gastroenterological Surgery Osaka University Graduate School of Medicine 2 2 Yamada oka Suita City Osaka Japan 3 Department of Surgery Kyushu University Beppu Hospital 4546 Tsurumibaru Beppu Oita Japan Correspondence Correspondence George A Calin Tel 1 713 792 5461 Fax 1 713 745 4528 E mail gcalin mdanderson org Recent studies suggest

    Original URL path: http://www.cell-research.com/arts.asp?id=1821 (2016-02-14)
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  • Cell Research
    Michigan A Alfred Taubman Medical Research Institute Ann Arbor MI 48109 2200 USA Correspondence Henry L Paulsona Tel 1 734 615 6156 Fax 1 734 615 5655 E mail henryp umich edu Maria do Carmo Costab Tel 1 734 615 6156 Fax 1 734 615 5655 E mail mariadoc umich edu E mail costa carmo gmail com The use of genetic screens to define cellular pathways that regulate neurodegenerative disease

    Original URL path: http://www.cell-research.com/arts.asp?id=1822 (2016-02-14)
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  • Cell Research
    The Years of the Monkey FREE Xiaojun Lian1 and Kenneth R Chien1 1Departments of Cell and Molecular Biology and Medicine Karolinska Institutet Stockholm Sweden Correspondence Kenneth R Chien E mail kenneth chien ki se The fact that mammals are diploid sets a barrier to rapidly understand the function of non coding and coding genes in the genome Recently Yang et al reported successful derivation of monkey haploid embryonic stem cells

    Original URL path: http://www.cell-research.com/arts.asp?id=1823 (2016-02-14)
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  • Cell Research
    1 Chikdu S Shivalila 1 4 Daniel B Dadon 1 4 and Rudolf Jaenisch 1 4 1 Whitehead Institute for Biomedical Research Cambridge MA 02142 USA 2 Computational and Systems Biology Program Massachusetts Institute of Technology Cambridge MA 02139 USA 3 Department of Brain and Cognitive Sciences Massachusetts Institute of Technology Cambridge MA 02139 USA 4 Department of Biology Massachusetts Institute of Technology Cambridge MA 02139 USA Correspondence Rudolf Jaenisch Tel 1 617 258 5186 E mail jaenisch wi mit edu Technologies allowing for specific regulation of endogenous genes are valuable for the study of gene functions and have great potential in therapeutics We created the CRISPR on system a two component transcriptional activator consisting of a nuclease dead Cas9 dCas9 protein fused with a transcriptional activation domain and single guide RNAs sgRNAs with complementary sequence to gene promoters We demonstrate that CRISPR on can efficiently activate exogenous reporter genes in both human and mouse cells in a tunable manner In addition we show that robust reporter gene activation in vivo can be achieved by injecting the system components into mouse zygotes Furthermore we show that CRISPR on can activate the endogenous IL1RN SOX2 and OCT4 genes The most efficient

    Original URL path: http://www.cell-research.com/arts.asp?id=1824 (2016-02-14)
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