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  • Cell Research
    MA 01238 USA 3 Stem Cell and Regenerative Medicine Consortium LKS Faculty of Medicine University of Hong Kong Pokfulam Hong Kong SAR China 4 Department of Cardiology Children s Hospital Boston MA 02115 USA 5 School of Engineering and Applied Sciences Harvard University Cambridge MA 02138 USA 6 Department of Biomedical Engineering University of California Davis CA 95616 USA 7 Cardiovascular Research Center Mount Sinai School of Medicine New York NY 10029 USA 8 Department of Cell and Molecular Biology Karolinska Institute SE 171 77 Stockholm Sweden Correspondence Kathy O Lui E mail kathyolui fas harvard edu Kenneth R Chien E mail kenneth chien ki se Distinct families of multipotent heart progenitors play a central role in the generation of diverse cardiac smooth muscle and endothelial cell lineages during mammalian cardiogenesis The identification of precise paracrine signals that drive the cell fate decision of these multipotent progenitors and the development of novel approaches to deliver these signals in vivo are critical steps towards unlocking their regenerative therapeutic potential Herein we have identified a family of human cardiac endothelial intermediates located in outflow tract of the early human fetal hearts OFT ECs characterized by coexpression of Isl1 and CD144 vWF By comparing angiocrine factors expressed by the human OFT ECs and non cardiac ECs vascular endothelial growth factor VEGF A was identified as the most abundantly expressed factor and clonal assays documented its ability to drive endothelial specification of human embryonic stem cell ESC derived Isl1 progenitors in a VEGF receptor dependent manner Human Isl1 ECs endothelial cells differentiated from hESC derived ISL1 progenitors resemble OFT ECs in terms of expression of the cardiac endothelial progenitor and endocardial cell specific genes confirming their organ specificity To determine whether VEGF A might serve as an in vivo cell fate switch for human

    Original URL path: http://www.cell-research.com/arts.asp?id=1825 (2016-02-14)
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  • Cell Research
    2 Hanzhi Zhao 3 Hui Wang 5 Fan Tang 3 Yan Wang 2 Chenchen Zhang 2 Xin yuan Liu 4 Dongmei Lai 5 Ying Jin 3 Qiang Sun 2 and Jinsong Li 1 1 Group of Epigenetic Reprogramming State Key Laboratory of Cell Biology Shanghai Key Laboratory of Molecular Andrology Institute of Biochemistry and Cell Biology Shanghai Jiao Tong University School of Medicine Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China 2 Institute of Neuroscience Shanghai Jiao Tong University School of Medicine Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China 3 Key Laboratory of Stem Cell Biology Institute of Health Sciences Shanghai Jiao Tong University School of Medicine Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China 4 College of Life Sciences Zhejiang Sci Tech University Hangzhou Zhejiang 310018 China 5 The International Peace Maternity and Child Health Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200030 China Correspondence Jinsong Li E mail jsli sibcb ac cn Qiang Sun E mail qsun ion ac cn Ying Jin E mail yjin sibs ac cn Recent success in the derivation of haploid embryonic stem cells haESCs from mouse via parthenogenesis and androgenesis has enabled genetic screening in mammalian cells and generation of gene modified animals However whether haESCs can be derived from primates remains unknown Here we report the derivation of haESCs from parthenogenetic blastocysts of Macaca fascicularis monkeys These cells termed as PG haESCs are pluripotent and can differentiate to cells of three embryonic germ layers in vitro or in vivo Interestingly the haploidy of one monkey PG haESC line MPH1 is more stable compared with that of the other one MPH2 as shown by the existence of haploid cells for more than 140 days without fluorescence activated cell

    Original URL path: http://www.cell-research.com/arts.asp?id=1826 (2016-02-14)
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  • Cell Research
    23 ISSUE 10 10 2013 1201 1214 A novel partner of Scalloped regulates Hippo signaling via antagonizing Scalloped Yorkie activity Tong Guo 1 Yi Lu 1 Peixue Li 1 Meng Xin Yin 1 Dekang Lv 1 Wenjing Zhang 1 Huizhen Wang 1 Zhaocai Zhou 1 Hongbin Ji 1 Yun Zhao 1 and Lei Zhang 1 1 State Key Laboratory of Cell Biology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences 320 Yue Yang Road Shanghai 200031 China Correspondence Lei Zhang E mail rayzhang sibcb ac cn Yun Zhao E mail yunzhao sibcb ac cn The Hippo Hpo pathway controls tissue growth and organ size by regulating the activity of transcriptional co activator Yorkie Yki which associates with transcription factor Scalloped Sd in the nucleus to promote downstream target gene expression Here we identify a novel protein Sd Binding Protein SdBP Tgi which directly competes with Yki for binding to Sd through its TDU domains and inhibits the Sd Yki transcriptional activity We also find that SdBP retains Yki in the nucleus through the association with Yki WW domains via its PPXY motifs Collectively we identify SdBP as a novel component of the Hpo

    Original URL path: http://www.cell-research.com/arts.asp?id=1827 (2016-02-14)
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  • Cell Research
    Department of Experimental Radiation Oncology The University of Texas MD Anderson Cancer Center Houston TX 77030 USA 3 Department of Genetics The University of Texas MD Anderson Cancer Center Houston TX 77030 USA 4 High Magnetic Field Laboratory Chinese Academy of Sciences Hefei Anhui 230031 China 5 Department of Molecular Carcinogenesis The University of Texas MD Anderson Cancer Center Smithville TX 78957 USA 6 National Laboratory for Physical Science at Microscale School of Life Sciences University of Science and Technology of China Hefei Anhui 230026 China Correspondence Weimin Gong E mail wgong ibp ac cn Lei Li E mail leili mdanerson org Changlin Tian E mail cltian ustc edu cn The FANCM FAAP24 heterodimer has distinct functions in protecting cells from complex DNA lesions such as interstrand crosslinks These functions rely on the biochemical activity of FANCM FAAP24 to recognize and bind to damaged DNA or stalled replication forks However the DNA binding activity of this complex was not clearly defined We investigated how FAAP24 contributes to the DNA interacting functions of the FANCM FAAP24 complex by acquiring the N terminal and C terminal solution structures of human FAAP24 Modeling of the FAAP24 structure indicates that FAAP24 may possess a

    Original URL path: http://www.cell-research.com/arts.asp?id=1828 (2016-02-14)
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  • Cell Research
    1 Dong Lei Yang 1 Pengliang Wei 1 Fengqiu Cao 1 Shihua Zhu 4 Feng Zhang 5 Yanfei Mao 1 and Jian Kang Zhu 1 6 1 Shanghai Center for Plant Stress Biology Chinese Academy of Sciences Shanghai 200032 China 2 Institute of Plant Physiology and Ecology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200032 China 3 University of Chinese Academy of Sciences Shanghai 200032 China 4

    Original URL path: http://www.cell-research.com/arts.asp?id=1829 (2016-02-14)
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  • Cell Research
    Wan 2 Hongya Gu 1 and Li Jia Qu 1 3 1 State Key Laboratory for Protein and Plant Gene Research Peking Tsinghua Center for Life Sciences College of Life Sciences Peking University Beijing 100871 China 2 National Key Facility for Crop Gene Resources and Genetic Improvement Institute of Crop Science Chinese Academy of Agricultural Sciences Beijing 100081 China 3 The National Plant Gene Research Center Beijing Beijing 100101 China

    Original URL path: http://www.cell-research.com/arts.asp?id=1830 (2016-02-14)
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  • Cell Research
    1 Zhi Xin Wang 1 and Jia Wei Wu 1 1 MOE Key Laboratory of Protein Science and Tsinghua Peking Center for Life Sciences School of Life Sciences Tsinghua University Beijing 100084 China Correspondence Jia Wei Wu Tel 86 10 62789387 Fax 86 10 62792826 E mail jiaweiwu mail tsinghua edu cn The AMP activated protein kinase AMPK is the key energy sensor in response to various stresses that decrease

    Original URL path: http://www.cell-research.com/arts.asp?id=1831 (2016-02-14)
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  • Cell Research

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    Original URL path: /artsmore1.asp?id=161 (2016-02-14)




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