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  • Cell Research
    1 2 Xiaoyi Yan 1 2 Xiaoqi Liu 3 and Tianhua Zhou 1 2 1 Department of Cell Biology and Program in Molecular Cell Biology Zhejiang University School of Medicine 866 Yuhangtang Road Hangzhou Zhejiang 310058 China 2 Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases Hangzhou 310003 China 3 Department of Biochemistry Purdue University West Lafayette IN 47907 USA Correspondence Tianhua Zhou Tel 86 571 88208258 Fax 86 571 88208069 E mail tzhou zju edu cn Centrosomes are required for efficient cell cycle progression mainly by orchestrating microtubule dynamics and facilitating G1 S and G2 M transitions However the role of centrosomes in S phase progression is largely unknown Here we report that depletion of FOR20 FOP related protein of 20 kDa a conserved centrosomal protein inhibits S phase progression and prevents targeting of Plk1 polo like kinase 1 to centrosomes where FOR20 interacts with Plk1 Ablation of Plk1 also significantly induces S phase defects which are reversed by ectopic expression of Plk1 even a kinase dead mutant but not a mutant that fails to localize to centrosomes Exogenous expression of centrosome tethered Plk1 but not wild type Plk1 overrides FOR20 depletion induced S phase defects independently

    Original URL path: http://www.cell-research.com/arts.asp?id=1842 (2016-02-14)
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  • Cell Research
    Chinese Academy of Sciences 320 Yue Yang Road Shanghai 200031 China 2 Graduate School of Chinese Academy of Sciences 320 Yue Yang Road Shanghai 200031 China Correspondence Jianping Ding Tel 086 21 5492 1619 Fax 086 21 5492 1116 E mail jpding sibcb ac cn DNA methylation and demethylation regulate many crucial biological processes in mammals and are linked to many diseases Active DNA demethylation is believed to be catalyzed by TET proteins and a putative DNA decarboxylase that may share some similarities in sequence structure and catalytic mechanism with isoorotate decarboxylase IDCase that catalyzes decarboxylation of 5caU to U in fungi We report here the structures of wild type and mutant IDCases from Cordyceps militaris and Metarhizium anisopliae in apo form or in complexes with 5caU U and an inhibitor 5 nitro uracil IDCases adopt a typical β α 8 barrel fold of the amidohydrolase superfamily and function as dimers A Zn2 is bound at the active site and coordinated by four strictly conserved residues one Asp and three His The substrate is recognized by several strictly conserved residues The functional roles of the key residues at the active site are validated by mutagenesis and biochemical studies Based on

    Original URL path: http://www.cell-research.com/arts.asp?id=1843 (2016-02-14)
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  • Cell Research
    Ji Qiu Wang 3 Bing Hao Wu 1 2 Zhuang Zhuang Zhang 1 2 Ying Yong Hou 4 Wei Ming Sun 5 Ren Ming Hu 6 Guang Ning 3 and Ze Guang Han 1 2 1 Key Laboratory of Systems Biomedicine Ministry of Education of Rui Jin Hospital Shanghai Jiao Tong University School of Medicine 197 Rui Jin 2nd Road Shanghai 200025 China 2 Shanghai MOST Key Laboratory for Disease and Health Genomics Chinese National Human Genome Center at Shanghai 351 Guo Shou Jing Road Shanghai 201203 China 3 Department of Endocrinology and Metabolism Rui Jin Hospital Shanghai Jiao Tong University School of Medicine 197 Rui Jin 2nd Road Shanghai 200025 China 4 Department of pathology Zhongshan Hospital Fudan University Shanghai 200032 China 5 Department of Endocrinology The First Hospital of Lanzhou University 1 Dong Gang West Road Lanzhou Gansu 730000 China 6 Department of Endocrinology and Metabolism Huashan Hospital Fudan University Shanghai 200040 China 7 Department of Medical Biochemistry and Molecular Biology School of Basic Medical Sciences Lanzhou University 199 Dong Gang West Road Lanzhou Gansu 730000 China Correspondence Ze Guang Han Tel 86 21 50801325 Fax 86 21 50800402 E mail hanzg chgc sh cn IRTKS encodes a member of the IRSp53 MIM homology domain family which has been shown to play an important role in the formation of plasma membrane protrusions Although the phosphorylation of IRTKS occurs in response to insulin stimulation the role of this protein in insulin signaling remains unknown Here we show that IRTKS deficient mice exhibit insulin resistance including hyperglycemia hyperinsulinemia glucose intolerance decreased insulin sensitivity and increased hepatic glucose production The administration of ectopic IRTKS can ameliorate the insulin resistance of IRTKS deficient and diabetic mice In parallel the expression level of IRTKS was significantly decreased in diabetic mouse model Furthermore DNA

    Original URL path: http://www.cell-research.com/arts.asp?id=1844 (2016-02-14)
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  • Cell Research
    Zhou 1 Xiaojun Zhu 1 and Jing Wei Xiong 1 1 Beijing Key Laboratory of Cardiometabolic Molecular Medicine Institute of Molecular Medicine Peking University Beijing China Correspondence Jing Wei Xiong Tel 8610 62766239 E mail jingwei xiong pku edu cn Xinli Hu E mail huxxx025 pku edu cn The rat is a preferred animal model in many research applications especially in physiological behavioral and translational studies1 Although the rat embryonic

    Original URL path: http://www.cell-research.com/arts.asp?id=1845 (2016-02-14)
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  • Cell Research
    recognizes the BRI1 bound brassinolide FREE Yadong Sun 1 Zhifu Han 1 Jiao Tang 1 Zehan Hu 1 Chengliang Chai 1 Bin Zhou 1 and Jijie Chai 1 1 Tsinghua Peking Center for Life Sciences Beijing 100084 China School of Life Sciences Tsinghua University Beijing 100084 China Correspondence Jijie Chai E mail chaijj mail tsinghua edu cn In animals steroid hormones play critical roles in many vital physiological processes Brassinosteroids

    Original URL path: http://www.cell-research.com/arts.asp?id=1846 (2016-02-14)
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  • Cell Research
    1333 Parthenogenetic haploid embryonic stem cells produce fertile mice Haifeng Wan Zhengquan He Mingzhu Dong Tiantian Gu Guan Zheng Luo Fei Teng Baolong Xia Wei Li Chunjing Feng Xin Li Tianda Li Ling Shuai Rui Fu Liu Wang Xiu Jie Wang Xiao Yang Zhao and Qi Zhou Abnormal oocytes are one of the major causes of reproductive failure and also limit the efficiency of assisted reproduction1 The generation of functional

    Original URL path: http://www.cell-research.com/arts.asp?id=1847 (2016-02-14)
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  • Cell Research

    (No additional info available in detailed archive for this subpage)
    Original URL path: /artsmore1.asp?id=162 (2016-02-14)


  • Cell Research
    crystal balls FREE Kwok Yung Yuen 1 1 State Key Laboratory for Emerging Infectious Diseases Department of Microbiology The University of Hong Kong Pokfulam Road Pokfulam Hong Kong SAR China Correspondence Kwok Yung Yuen E mail kyyuen hkucc hku hk How the novel influenza H7N9 virus crossed species barrier from avian to human is intriguing Extrapolation from previous studies on H5N1 can be misleading as illustrated by crystallographic studies on

    Original URL path: http://www.cell-research.com/arts.asp?id=1848 (2016-02-14)
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