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  • Cell Research
    cancer effects of vitamin C revisited FREE Jiska van der Reest 1 and Eyal Gottlieb 1 1 Cancer Metabolism Research Unit Cancer Research UK Beatson Institute Glasgow UK Correspondence Eyal Gottlieb E mail e gottlieb beatson gla ac uk Vitamin C was first suggested to have cancer fighting properties in the 1930s and has been the subject of controversy ever since Despite repeated reports of selective cancer cell toxicity induced

    Original URL path: http://www.cell-research.com/aoparts.asp?id=454 (2016-02-14)
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  • Cell Research
    Liu 1 3 12 13 1 National Laboratory of Biomacromolecules Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China 2 Biodynamic Optical Imaging Center College of Life Sciences Peking University Beijing 100871 China 3 FSU CAS Innovation Institute Foshan Guangdong 528000 China 4 State Key Laboratory of Stem Cell and Reproductive Biology Institute of Zoology Chinese Academy of Sciences Beijing 100101 China 5 Gene Expression Laboratory Salk Institute for Biological Studies La Jolla CA 92037 USA 6 Department of Pathology Carver College of Medicine University of Iowa Iowa City IA 52242 USA 7 Institute of Aging Research Leibniz Link Partner Group on Stem Cell Aging Hangzhou Normal University School of Medicine Hangzhou Zhejiang 310036 China 8 School of life sciences and technology Tongji University Shanghai 200092 China 9 The Key Laboratory of Geriatrics Beijing Hospital Beijing Institute of Geriatrics Ministry of Health Beijing 100730 China 10 Ministry of Education Key Laboratory of Cell Proliferation and Differentiation Beijing 100871 China 11 Peking Tsinghua Center for Life Sciences Peking University Beijing 100871 China 12 Center for Molecular and Translational Medicine CMTM Beijing 100101 China 13 Beijing Institute for Brain Disorders Beijing 100069 China Correspondence Guang Hui Liu E mail ghliu ibp ac cn Fuchou Tang E mail tangfuchou pku edu cn Jing Qu E mail qujing ioz ac cn SIRT6 belongs to the mammalian homologs of Sir2 histone NAD dependent deacylase family In rodents SIRT6 deficiency leads to aging associated degeneration of mesodermal tissues It remains unknown whether human SIRT6 has a direct role in maintaining the homeostasis of mesodermal tissues To this end we generated SIRT6 knockout human mesenchymal stem cells hMSCs by targeted gene editing SIRT6 deficient hMSCs exhibited accelerated functional decay a feature distinct from typical premature cellular senescence Rather than compromised chromosomal stability SIRT6 null hMSCs were

    Original URL path: http://www.cell-research.com/aoparts.asp?id=455 (2016-02-14)
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  • Cell Research
    of Hepatobiliary Surgery the Affiliated Drum Tower Hospital Medical School of Nanjing University Nanjing Jiangsu China 2 State Key Laboratory of Cell Biology Shanghai Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academic of Sciences Shanghai 200031 China 3 School of Life Science and Technology ShanghaiTech University Shanghai China 4 Center for Drug Safety Evaluation and Research Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai China 5 State Key Laboratory of Bioreactor Engineering School of Bioengineering East China University of Science and Technology Shanghai China 6 Department of Pathology Zhongshan Hospital Fudan University Shanghai China Correspondence Lijian Hui E mail ljhui sibcb ac cn Yi Tao Ding E mail yitaoding hotmail com Guoyu Pan E mail gypan cdser simm ac cn Acute liver failure ALF is a life threatening illness The extracorporeal cell based bioartificial liver BAL system could bridge liver transplantation and facilitate liver regeneration for ALF patients by providing metabolic detoxification and synthetic functions Previous BAL systems based on hepatoma cells and non human hepatocytes achieved limited clinical advances largely due to poor hepatic functions cumbersome preparation or safety concerns of these cells We previously generated human functional hepatocytes by lineage conversion

    Original URL path: http://www.cell-research.com/aoparts.asp?id=456 (2016-02-14)
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  • Cell Research
    Guo 1 and Yangming Wang 1 1 Beijing Key Laboratory of Cardiometabolic Molecular Medicine Peking Tsinghua Center for Life Science Institute of Molecular Medicine Peking University Beijing 100871 China 2 Department of Biomedical Informatics School of Basic Medical Sciences Peking University Health Science Center Peking University Beijing 100083 China Correspondence Yangming Wang E mail yangming wang pku edu cn The molecular mechanism controlling the dismantling of naive pluripotency is poorly understood Here we show that microRNAs miRNAs have important roles during naive to primed pluripotency transition Dgcr8 embryonic stem cells ESCs failed to completely silence the naive pluripotency program as well as to establish the primed pluripotency program during differentiation miRNA profiling revealed that expression levels of a large number of miRNAs changed dynamically and rapidly during naive to primed pluripotency transition Furthermore a miRNA screen identified numerous miRNAs promoting naive to primed pluripotency transition Unexpectedly multiple miRNAs from miR 290 and miR 302 clusters previously shown as pluripotency promoting miRNAs demonstrated the strongest effects in silencing naive pluripotency Knockout of both miR 290 and miR 302 clusters but not either alone blocked the silencing of naive pluripotency program Mechanistically the miR 290 302 family of miRNAs may facilitate the

    Original URL path: http://www.cell-research.com/aoparts.asp?id=452 (2016-02-14)
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  • Cell Research
    1 3 1 Genomics and Immunoregulation LIMES Institute University of Bonn 53115 Bonn Germany 2 Schultze Know How Beteiligungsgesellschaft mbH Kirschblütenweg 2 53639 Königswinter Germany 3 German Center for Neurodegenerative Diseases 53175 Bonn Germany Correspondence Joachim L Schultze E mail j schultze uni bonn de Differentiation of inflammatory macrophages from monocytes is characterized by an orderly integration of epigenetic and transcriptional regulatory mechanisms guided by lineage determining transcription factors such as PU 1 Further activation of macrophages leads to a stimulus or microenvironment specific signal integration with subsequent transcriptional control established by the action of tissue or signal associated transcription factors Here we assess four histone modifications during human macrophage activation and integrate this information with the gene expression data from 28 different macrophage activation conditions in combination with GM CSF Bioinformatically for inflammatory macrophages we define a unique network of transcriptional and epigenetic regulators TRs which was characterized by accessible promoters independent of the activation signal In contrast to the general accessibility of promoters of TRs mRNA expression of central TRs belonging to the TR network displayed stimulus specific expression patterns indicating a second level of transcriptional regulation beyond epigenetic chromatin changes In contrast stringent integration of epigenetic and

    Original URL path: http://www.cell-research.com/aoparts.asp?id=451 (2016-02-14)
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  • Cell Research
    Xueliang Zhu 3 Wei Liu 1 Yuehong Yang 1 2 and Tianhua Zhou 1 2 1 Department of Cell Biology and Program in Molecular Cell Biology Zhejiang University School of Medicine Hangzhou Zhejiang 310058 China 2 Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases Hangzhou Zhejiang 310003 China 3 State Key Laboratory of Cell Biology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences 320 Yue Yang Road Shanghai 200031 China Correspondence Tianhua Zhou Tel 86 571 88208258 E mail tzhou zju edu cn Yuehong Yang Tel 86 571 88208257 E mail yhyang zju edu cn Emerging data indicate that actin dynamics is associated with ciliogenesis However the underlying mechanism remains unclear Here we find that nuclear distribution gene C NudC an Hsp90 co chaperone is required for actin organization and dynamics Depletion of NudC promotes cilia elongation and increases the percentage of ciliated cells Further results show that NudC binds to and stabilizes cofilin 1 a key regulator of actin dynamics Knockdown of cofilin 1 also facilitates ciliogenesis Moreover depletion of either NudC or cofilin 1 causes similar ciliary defects in zebrafish including curved body pericardial edema and defective left right

    Original URL path: http://www.cell-research.com/aoparts.asp?id=450 (2016-02-14)
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  • Cell Research
    Top 10 Organotropic metastasis role of tumor exosomes Yang Liu 1 and Xuetao Cao 1 1 National Key Laboratory of Medical Molecular Biology Department of Immunology Institute of Basic Medical Sciences Peking Union Medical College Chinese Academy of Medical Sciences Beijing 100005 China Correspondence Xuetao Cao E mail caoxt immunol org A recent paper in Nature shows that tumor exosomes expressing unique integrins can determine organotropic metastasis by preparing pre

    Original URL path: http://www.cell-research.com/aoparts.asp?id=448 (2016-02-14)
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  • Cell Research
    demethylase spr 5 extends transgenerational longevity FREE Eric Lieberman Greer 1 Ben Becker 3 Christian Latza 3 Adam Antebi 3 4 and Yang Shi 1 2 1 Division of Newborn Medicine Children s Hospital Boston 300 Longwood Avenue Boston MA 02115 USA 2 Department of Cell Biology Harvard Medical School Boston MA 02115 USA 3 Max Planck Institute for Biology of Ageing 50931 Cologne Germany 4 Cologne Excellence Cluster on Cellular Stress Responses in Ageing Associated Diseases University of Cologne D 50674 Cologne Germany Correspondence Yang Shi E mail yang shi hms harvard edu Eric Lieberman Greer E mail eric greer childrens harvard edu Complex organismal properties such as longevity can be transmitted across generations by non genetic factors Here we demonstrate that deletion of the C elegans histone H3 lysine 4 dimethyl H3K4me2 demethylase spr 5 causes a trans generational increase in lifespan We identify a chromatin modifying network which regulates this lifespan extension We further show that this trans generational lifespan extension is dependent on a hormonal signaling pathway involving the steroid dafachronic acid an activator of the nuclear receptor DAF 12 These findings suggest that loss of the demethylase SPR 5 causes H3K4me2 mis regulation and activation

    Original URL path: http://www.cell-research.com/aoparts.asp?id=446 (2016-02-14)
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