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  • Cell Research
    Center for Orphan Disease Research Howard Hughes Medical Institute Children s Hospital Boston and Dana Farber Cancer Institute Boston MA 02115 USA 2 Department of Biological Chemistry and Molecular Pharmacology Harvard Medical School Boston MA 02115 USA 3 Broad Institute Boston MA 02115 USA 4 Harvard Stem Cell Institute Boston MA 02115 USA Correspondence George Q Daley E mail george daley childrens harvard edu Pluripotency can be experimentally induced from

    Original URL path: http://www.cell-research.com/arts.asp?id=1849 (2016-02-14)
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  • Cell Research
    McCoy 1 and Andrew J Macpherson 1 1 University of Bern Maurice Müller Laboratories DKF University Clinic for Visceral Surgery and Medicine Murtenstrasse 35 CH 3010 Bern Switzerland Correspondence Andrew J Macpherson Tel 41 31 632 8025 E mail andrew macpherson insel ch Intestinal bacterial metabolites are an important communication tool between the host immune system and the commensal microbiota to establish mutualism In a recent paper published in Science

    Original URL path: http://www.cell-research.com/arts.asp?id=1850 (2016-02-14)
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  • Cell Research
    le Cancer Centre de Recherche des Cordeliers Paris France 4INSERM U848 Villejuif France 5Pôle de Biologie Hôpital Européen Georges Pompidou AP HP Paris France 6Metabolomics and Cell Biology Platforms Gustave Roussy Villejuif France Correspondence Guido Kroemer Tel 33 1 4211 4516 Fax 33 1 4211 6047 E mail kroemer orange fr Lorenzo Galluzzi Tel 33 1 4211 6046 Fax 33 1 4211 6047 E mail deadoc vodafone it In a

    Original URL path: http://www.cell-research.com/arts.asp?id=1851 (2016-02-14)
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  • Cell Research
    Washington Seattle WA98115 USA Correspondence Christine Disteche E mail cdistech u washington edu Trisomy 21 in human causes Down syndrome a common chromosome disorder with devastating phenotypes ranging from early death in utero to intellectual disability together with an array of physical anomalies and late onset diseases In a recent study published in Nature Jeanne Lawrence and her colleagues restored normal gene expression in trisomy 21 cells by silencing the

    Original URL path: http://www.cell-research.com/arts.asp?id=1853 (2016-02-14)
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  • Cell Research
    China 3 Research Network of Immunity and Health RNIH Beijing Institutes of Life Science Chinese Academy of Sciences Beijing 100101 China 4 Laboratory of Protein Engineering and Vaccines Tianjin Institute of Industrial Biotechnology Tianjin 300308 China 5 Laboratory of Non coding RNA Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China 6 School of Life Sciences Sichuan University Chengdu Sichuan 610064 China 7 State Key Laboratory of Pathogen and Biosecurity Institute of Microbiology and Epidemiology Academy of Military Medical Sciences Beijing 100071 China 8 Shanghai Institute of Applied Physics Chinese Academy of Sciences 239 Zhangheng Road Shanghai 201204 China 9 Office of Director General Chinese Center for Disease Control and Prevention China CDC Beijing 102206 China Correspondence George F Gao Tel 86 10 64807688 Fax 86 10 64807882 E mail gaof im ac cn An epidemic of an avian origin H7N9 influenza virus has recently emerged in China infecting 134 patients of which 45 have died This is the first time that an influenza virus harboring an N9 serotype neuraminidase NA has been known to infect humans H7N9 viruses are divergent and at least two distinct NAs and hemagglutinins HAs have been found respectively from clinical isolates The prototypes of these viruses are A Anhui 1 2013 and A Shanghai 1 2013 NAs from these two viruses are distinct as the A Shanghai 1 2013 NA has an R294K substitution that can confer NA inhibitor oseltamivir resistance Oseltamivir is by far the most commonly used anti influenza drug due to its potency and high bioavailability In this study we show that an R294K substitution results in multidrug resistance with extreme oseltamivir resistance over 100 000 fold using protein and virus based assays To determine the molecular basis for the inhibitor resistance we solved high resolution crystal structures of NAs

    Original URL path: http://www.cell-research.com/arts.asp?id=1854 (2016-02-14)
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  • Cell Research
    vertebrates FREE Xinyan Lu 1 Xiajuan Li 1 Qiuping He 1 Jiao Gao 2 Ya Gao 1 Bing Liu 2 and Feng Liu 1 1 State Key Laboratory of Biomembrane and Membrane Biotechnology Institute of Zoology Chinese Academy of Sciences Beijing 100101 China 2 307 Ivy Translational Medicine Center Laboratory of Oncology Affiliated Hospital of Academy of Military Medical Sciences Beijing 100071 China Correspondence Feng Liu Tel 86 10 64807307 Fax 86 10 64807313 E mail liuf ioz ac cn Previous studies on developmental hematopoiesis have mainly focused on signaling and transcription factors while the appreciation of epigenetic regulation including that of microRNAs is recent Here we show that in zebrafish and mouse miR 142 3p is specifically expressed in hematopoietic stem cells HSCs Knockdown of miR 142a 3p in zebrafish led to a reduced population of HSCs in the aorta gonad mesonephros AGM region as well as T cell defects in the thymus Mechanistically miR 142a 3p regulates HSC formation and differentiation through the repression of interferon regulatory factor 7 irf7 mediated inflammation signaling Finally we show that miR 142 3p is also involved in the development of HSCs in mouse AGM suggesting that it has a highly conserved

    Original URL path: http://www.cell-research.com/arts.asp?id=1855 (2016-02-14)
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  • Cell Research
    2 3 Ping Yin 1 2 3 and Nieng Yan 1 2 3 1 State Key Laboratory of Bio membrane and Membrane Biotechnology Tsinghua University Beijing 100084 China 2 Center for Structural Biology School of Medicine and School of Life Sciences Tsinghua University Beijing 100084 China 3 Tsinghua Peking Center for Life Sciences Tsinghua University Beijing 100084 China Correspondence Nieng Yan E mail nyan tsinghua edu cn PYR1 PYL RCAR family proteins PYLs are well characterized abscisic acid ABA receptors Among the 14 PYL members in Arabidopsis thaliana PYL13 is ABA irresponsive and its function has remained elusive Here we show that PYL13 selectively inhibits the phosphatase activity of PP2CA independent of ABA The crystal structure of PYL13 PP2CA complex which was determined at 2 4 Å resolution elucidates the molecular basis for the specific recognition between PP2CA and PYL13 In addition to the canonical interactions between PYLs and PP2Cs an extra interface is identified involving an element in the vicinity of a previously uncharacterized CCCH zinc finger ZF motif in PP2CA Sequence blast identified another 56 ZF containing PP2Cs all of which are from plants The structure also reveals the molecular determinants for the ABA irresponsiveness of PYL13 Finally

    Original URL path: http://www.cell-research.com/arts.asp?id=1856 (2016-02-14)
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  • Cell Research
    Pengcheng Wang 2 Chengguo Duan 2 and Jian Kang Zhu 1 2 1 Shanghai Center for Plant Stress Biology and Shanghai Institute of Plant Physiology and Ecology Shanghai Institutes of Biological Sciences Chinese Academy of Sciences Shanghai 200032 China 2 Department of Horticulture and Landscape Architecture Purdue University West Lafayette IN 47906 USA 3 Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture Wuhan Botanical Garden Chinese Academy of Sciences Wuhan Hubei 430074 China 4 School of Life Sciences University of Science and Technology of China Hefei Anhui 230026 China 5 Division of Plant Physiology Indian Agricultural Research Institute New Delhi 110012 India Correspondence Jian Kang Zhu E mail jkzhu purdue edu Proteins in the PYR PYL RCAR family PYLs are known as receptors for the phytohormone ABA Upon ABA binding PYL adopts a conformation that allows it to interact with and inhibit clade A protein phosphatase 2Cs PP2Cs which are known as the co receptors for ABA Inhibition of the PP2Cs then leads to the activation of the SnRK2 family protein kinases that phosphorylate and activate downstream effectors in ABA response pathways The PYL family has 14 members in Arabidopsis 13 of which have been demonstrated to function as ABA receptors The function of PYL13 a divergent member of the family has been enigmatic We report here that PYL13 differs from the other PYLs in three key residues that affect ABA perception and mutations in these three residues can convert PYL13 into a partially functional ABA receptor Transgenic plants overexpressing PYL13 show increased ABA sensitivity in seed germination and postgermination seedling establishment as well as decreased stomatal conductance increased water use efficiency accelerated stress responsive gene expression and enhanced drought resistance pyl13 mutant plants are less sensitive to ABA inhibition of postgermination seedling establishment PYL13 interacts with and inhibits

    Original URL path: http://www.cell-research.com/arts.asp?id=1857 (2016-02-14)
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