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  • Cell Research
    of Experimental Radiation Oncology MD Anderson Cancer Center Houston TX 77030 USA 3 Department of Genetics MD Anderson Cancer Center Houston TX 77030 USA Correspondence Sandy Chang E mail schang yale edu The INO80 inositol requiring mutant 80 chromatin remodeling complex plays important roles in transcriptional regulation and DNA replication and repair and consists of several functional protein subunits including the critical Ino80 ATPase catalytic subunit While the function of INO80 has been studied in yeast and mammalian cell lines we do not know how mIno80 contributes to the maintenance of genome stability to prevent cancer development in mice Here we use a conditional knockout approach to explore the cellular and organismal functions of mIno80 Deletion of mIno80 results in profound cellular proliferative defects and activation of p21 dependent cellular senescence While mIno80 is required for efficient repair of DNA double strand breaks its depletion did not impact upon the formation of γ H2AX and 53BP1 DNA damage foci or the activation of the ATM CHK2 dependent DNA damage response mIno80 deletion inhibited the generation of single strand DNA resulting in defects in homology directed DNA repair HDR at telomeres Fragile telomeres were prominent in mIno80Δ Δ MEFs suggesting that

    Original URL path: http://www.cell-research.com/arts.asp?id=1858 (2016-02-14)
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  • Cell Research
    Lin Ling 1 Lang You 1 Yazhou Chen 1 Yongping Huang 1 and Anjiang Tan 1 1 Key Laboratory of Insect Developmental and Evolutionary Biology Institute of Plant Physiology and Ecology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200032 China 2 University of Chinese Academy of Sciences Beijing 100049 China Correspondence Yongping Huang E mail yphuang sibs ac cn Tel 86 21 54924047 Fax 86 21 54924015

    Original URL path: http://www.cell-research.com/arts.asp?id=1859 (2016-02-14)
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  • Cell Research
    1419 Crystal structure of mammalian cryptochrome in complex with a small molecule competitor of its ubiquitin ligase Shannon Nangle 1 Weiman Xing 1 2 and Ning Zheng 1 2 1 Department of Pharmacology University of Washington Seattle WA 98195 USA 2 Howard Hughes Medical Institute Box 357280 University of Washington Seattle WA 98195 USA Correspondence Weiman Xing E mail wxing uw edu Ning Zheng E mail nzheng uw edu The

    Original URL path: http://www.cell-research.com/arts.asp?id=1860 (2016-02-14)
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  • Cell Research
    Correspondence Yixian Zheng Tel 1 410 246 3032 Fax 1 410 243 6311 E mail zheng ciwemb edu Lamins are the major components of the nuclear lamina NL which is located underneath the inner nuclear membrane1 Diverse array of functions have been assigned to lamins and alterations of lamins are associated with a number of human diseases2 Of the three lamin genes in mammals Lmna expresses all isoforms of A

    Original URL path: http://www.cell-research.com/arts.asp?id=1861 (2016-02-14)
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  • Cell Research

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    Original URL path: /artsmore1.asp?id=164 (2016-02-14)


  • Cell Research
    Life Sciences School of Life Sciences Tsinghua University Beijing 100084 China E mail liyulab mail tsinghua edu cn Autophagy is a lysosome based degradation process whose primary function is to degrade long lived proteins and recycle cellular components So far 3 types of autophagy have been documented including macroautophagy microautophagy and chaperone mediated autophagy Autophagy has been shown to degrade cargo in selective and no selective manners In literature the term autophagy usually indicates macroautophagy Macroautophagy is characterized by the formation of double membrane vesicles termed autophagosomes The biogenesis of autophagosomes is a subject of intensive study in recent years Autophagy can be induced by various stimuli including nutrient starvation hypoxia and various chemical reagents such as rapamycin In yeast the major physiological function of autophagy is to adjust the metabolic machinery in response to varying nutrient status thereby ensuring the cell survival in an ever changing environment In mammalian cells however the roles of autophagy are more complex Autophagy has been implicated in many different cellular processes as varied as cell survival death pathogen clearance and antigen presentation Various diseases have been linked to dysfunctioning autophagy There are strong genetic and animal data supporting the direct connections between autophagy

    Original URL path: http://www.cell-research.com/arts.asp?id=1862 (2016-02-14)
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  • Cell Research
    T Stiemsma 1 Stuart E Turvey 2 and Brett B Finlay 1 1 Department of Microbiology Immunology University of British Columbia Vancouver BC V6T 1Z4 2 Department of Pediatrics Child Family Research Institute Vancouver BC V5Z 4H4 Correspondence Brett B Finlay E mail bfinlay msl ubc ca Antibiotic therapies disrupt the intestinal microbiota and render the host susceptible to enteric infections A recent report by Ng et al explores the

    Original URL path: http://www.cell-research.com/arts.asp?id=1864 (2016-02-14)
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  • Cell Research
    The disposable soma theory of aging in reverse FREE Peter M Douglas 1 2 3 and Andrew Dillin 1 2 3 1 California Institute for Regenerative Medicine Berkeley CA 94720 3370 USA 2 Howard Hughes Medical Institute Berkeley CA 94720 3370 USA 3 University of California Berkeley CA 94720 3370 USA Correspondence Andrew Dillin E mail dillin berkeley edu In a recent paper in Nature Ermolaeva et al uncover a

    Original URL path: http://www.cell-research.com/arts.asp?id=1865 (2016-02-14)
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