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  • Cell Research
    Top 10 VOLUME 24 ISSUE 1 1 2014 122 125 Generating rats with conditional alleles using CRISPR Cas9 FREE Yuanwu Ma 1 Xu Zhang 1 Bin Shen 2 Yingdong Lu 1 Wei Chen 1 Jing Ma 1 Lin Bai 1 Xingxu Huang 2 and Lianfeng Zhang 1 1 Key Laboratory of Human Disease Comparative Medicine Ministry of Health Institute of Laboratory Animal Science Chinese Academy of Medical Sciences Beijing 100021 China 2 MOE Key Laboratory of Model Animal for Disease Study Model Animal Research Center of Nanjing University Nanjing Biomedical Research Institute National Resource Center for Mutant Mice Nanjing Jiang Su 210061 China Correspondence Lianfeng Zhang E mail zhanglf cnilas org Xingxu Huang E mail xingxuhuang mail nju edu cn The rat is an important laboratory model and has many advantages over mouse models especially in toxicology and pharmacology studies Several genome editing technologies such as zinc finger nucleases ZFNs 1 2 transcription activator like effector nucleases TALENs 3 and the Clustered Regularly Interspaced Short Palindromic Repeats CRISPR CRISPR associated 9 Cas9 system4 5 have been used to produce knockout rat models by generating DNA double strand breaks DSBs followed by non homologous end joining NHEJ mediated repair However the

    Original URL path: http://www.cell-research.com/arts.asp?id=1873 (2016-02-14)
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  • Cell Research
    Saleem 2 Sara Sanz Blasco 2 Eliezer Masliah 5 Scott R McKercher 2 Yee Sook Cho 4 Stuart A Lipton 2 5 Janghwan Kim 1 4 and Sheng Ding 1 1 Gladstone Institute of Cardiovascular Disease Department of Pharmaceutical Chemistry University of California San Francisco 1650 Owens Street San Francisco CA 94158 USA 2 Del E Webb Center for Neuroscience Aging and Stem Cell Research Sanford Burnham Medical Research Institute 10901 North Torrey Pines Road La Jolla CA 92037 USA 3 Department of Anatomy Korea University College of Medicine Seoul 136 705 Korea 4 Stem Cell Research Center Korea Research Institute of Bioscience and Biotechnology 125 Gwahak ro Yuseong gu Daejeon 305 806 Korea 5 Department of Neurosciences University of California San Diego 9500 Gilman Drive La Jolla CA 92093 USA Correspondence Sheng Ding Tel 415 734 2717 Fax 415 355 0141 E mail sheng ding gladstone ucsf edu Janghwan Kim Tel 82 42 860 4478 Fax 82 42 879 8495 E mail janghwan kim kribb re kr We previously developed a novel paradigm of cell activation and signaling directed CASD lineage conversion for direct reprogramming of fibroblasts into cardiac neural and endothelial precursor cells This method is based on

    Original URL path: http://www.cell-research.com/arts.asp?id=1874 (2016-02-14)
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  • Cell Research
    Jin 1 Wentao Dong 1 Jiyun Liu 1 Huan Liu 1 Weibing Yang 1 Longjun Zeng 1 Qun Li 1 Zuhua He 1 Giles E D Oldroyd 2 and Ertao Wang 1 1 National Key Laboratory of Plant Molecular Genetics Institute of Plant Physiology and Ecology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200032 China 2 John Innes Centre Norwich Research Park Norwich NR4 7UH UK Correspondence Ertao Wang E mail etwang sibs ac cn lants establish beneficial symbiotic associations with arbuscular mycorrhizal fungi which colonize the root cortex building specialized structures called arbuscules that facilitate nutrient exchange The association occurs following plant recognition of lipochitooligosaccharides LCOs from mycorrhizal fungi which activates the symbiosis signaling pathway prior to mycorrhizal colonization Here we show that SLR1 DELLA a repressor of gibberellic acid GA signaling and its interacting partner protein are required for the mycorrhizal symbiosis GA treatment inhibits mycorrhizal colonization and leads to the degradation of DELLAs Consistently rice lines mutated in DELLA are unable to be colonized by mycorrhizal fungi DELLAs are members of the GRAS family of transcription factors We further show that rice DELLA interacts with a second GRAS protein DIP1 DELLA Interacting Protein 1

    Original URL path: http://www.cell-research.com/arts.asp?id=1875 (2016-02-14)
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  • Cell Research

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    Original URL path: /artsmore1.asp?id=165 (2016-02-14)


  • Cell Research
    1 2 and Georg Halder 1 2 1 VIB Center for the Biology of Disease University of Leuven 3000 Leuven Belgium 2 KU Leuven Center for Human Genetics University of Leuven 3000 Leuven Belgium Correspondence Georg Halder E mail Georg Halder vib be The Hippo pathway is a signal transduction pathway that regulates organ growth stem cell biology regeneration and cancer Three recent proteomic studies with Hippo pathway components uncovered

    Original URL path: http://www.cell-research.com/arts.asp?id=1877 (2016-02-14)
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  • Cell Research
    Descartes Paris V Sorbonne Paris Cité Paris France 3 Equipe 11 labellisée Ligue Nationale contre le Cancer Centre de Recherche des Cordeliers Paris France 4 INSERM U848 Villejuif France 5 Metabolomics and Cell Biology Platforms Gustave Roussy Villejuif France 6 Pôle de Biologie Hôpital Européen Georges Pompidou AP HP Paris France Correspondence Lorenzo Galluzzi E mail deadoc vodafone it Guido Kroemer E mail kroemer orange fr Recent data from two

    Original URL path: http://www.cell-research.com/arts.asp?id=1878 (2016-02-14)
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  • Cell Research
    100101 China 2 Gene Expression Laboratory Salk Institute for Biological Studies 10010 North Torrey Pines Road La Jolla CA 92037 USA 3 Beijing Institute for Brain Disorders Beijing 100069 China 4 Center for Regenerative Medicine in Barcelona Dr Aiguader 88 Barcelona 08003 Spain Correspondence Guang Hui Liu E mail ghliu ibp ac cn Juan Carlos Izpisua Belmonte E mail belmonte salk edu E mail izpisua cmrb eu A major challenge

    Original URL path: http://www.cell-research.com/arts.asp?id=1879 (2016-02-14)
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  • Cell Research
    1 and Jeanne F Loring 1 1 Department of Chemical Physiology Center for Regenerative Medicine The Scripps Research Institute 10550 N Torrey Pines Rd La Jolla CA 92037 USA Correspondence Yu Chieh Wang Tel 1 858 784 7139 Fax 1 858 784 7211 E mail ycwang scripps edu Jeanne F Loring Tel 1 858 784 7362 Fax 1 858 784 7211 E mail jloring scripps edu Post translational modifications PTMs are known to be essential mechanisms used by eukaryotic cells to diversify their protein functions and dynamically coordinate their signaling networks Defects in PTMs have been linked to numerous developmental disorders and human diseases highlighting the importance of PTMs in maintaining normal cellular states Human pluripotent stem cells hPSCs including embryonic stem cells hESCs and induced pluripotent stem cells hiPSCs are capable of self renewal and differentiation into a variety of functional somatic cells these cells hold a great promise for the advancement of biomedical research and clinical therapy The mechanisms underlying cellular pluripotency in human cells have been extensively explored in the past decade In addition to the vast amount of knowledge obtained from the genetic and transcriptional research in hPSCs there is a rapidly growing interest in the

    Original URL path: http://www.cell-research.com/arts.asp?id=1880 (2016-02-14)
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