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  • Cell Research
    Wang 1 Zhiyin Song 6 Xiaojiang Hao 3 and Quan Chen 1 2 4 1 Laboratory of Apoptosis and Mitochondrial Biology The State Key Laboratory of Biomembrane and Membrane Biotechnology Institute of Zoology Chinese Academy of Sciences Beijing 100101 China 2 University of Chinese Academy of Sciences Beijing 100049 China 3 The State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences Kunming 650204 China 4 College of Life Sciences Nankai University Tianjin 300071 China 5 State Key Laboratory of Biomembrane and Membrane Biotechnology Institute of Molecular Medicine Peking Tsinghua Center for Life Sciences Peking University Beijing 100871 China 6 College of Life Sciences Wuhan University Wuhan Hubei 430072 China Correspondence Quan Chen E mail chenq ioz ac cn Tel 86 010 64807322 Xiaojiang Hao Tel 86 0871 5219684 E mail haoxj mail kib ac cn Mitochondrial fusion is a highly coordinated process that mixes and unifies the mitochondrial compartment for normal mitochondrial functions and mitochondrial DNA inheritance Dysregulated mitochondrial fusion causes mitochondrial fragmentation abnormal mitochondrial physiology and inheritance and has been causally linked with a number of neuronal diseases Here we identified a diterpenoid derivative 15 oxospiramilactone S3 that potently

    Original URL path: http://www.cell-research.com/arts.asp?id=1912 (2016-02-14)
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  • Cell Research
    and biochemical analysis of the heptameric Lsm1 7 complex OPEN Lijun Zhou 1 3 Yulin Zhou 1 Jing Hang 2 3 Ruixue Wan 2 Guifeng Lu 2 Chuangye Yan 2 3 and Yigong Shi 1 3 1 Ministry of Education Key Laboratory of Protein Science Center for Structural Biology School of Life Sciences and School of Medicine Tsinghua University Beijing 100084 China 2 State Key Laboratory of Bio membrane and Membrane Biotechnology Center for Structural Biology School of Life Sciences and School of Medicine Tsinghua University Beijing 100084 China 3 Tsinghua Peking Joint Center for Life Sciences Center for Structural Biology School of Life Sciences and School of Medicine Tsinghua University Beijing 100084 China Correspondence Yigong Shi E mail shi lab tsinghua edu cn The Lsm Sm like family of proteins characterized by the Sm fold1 and conserved among eukaryotes plays an important role in RNA biogenesis The Sm and Lsm complexes play an essential role in pre mRNA splicing2 Of the five small ribonucleoproteins snRNPs four U1 U2 U4 U5 contain the Sm heptamer ring whereas the U6 snRNP contains a specific Lsm2 8 heptamer that comprises Lsm2 Lsm3 Lsm4 Lsm5 Lsm6 Lsm7 and Lsm83 Another Lsm heptameric complex

    Original URL path: http://www.cell-research.com/arts.asp?id=1913 (2016-02-14)
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  • Cell Research
    Yu Zhao 2 Xiaoling Yi 2 Longquan Quan 1 Songcai Liu 1 Zhenguo Yang 1 Hongsheng Ouyang 1 Y Eugene Chen 3 Zhong Wang 3 and Liangxue Lai 1 2 1 Jilin Provincial Key Laboratory of Animal Embryo Engineering Institute of Zoonosis College of Veterinary Medicine Jilin University Changchun 130062 China 2 Key Laboratory of Regenerative Biology Chinese Academy of Sciences Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine Guangzhou Institutes of Biomedicine and Health Guangzhou Guangdong 510530 China 3 Department of Cardiac Surgery Cardiovascular Research Center University of Michigan 2800 Plymouth Road Ann Arbor MI 48109 USA 4 Leon H Charney Division of Cardiology New York University School of Medicine 522 First Avenue New York NY 10016 USA Correspondence Liangxue Lai E mail lai liangxue gibh ac cn Zhong Wang E mail E mail zhongw med umich edu Genetic modification of pigs has many agricultural and biomedical applications Ectopic overexpression of foreign genes is necessary in many cases to generate transgenic pigs with favorable phenotypes1 However random integration of foreign genes often leads to unpredictable expression and unstable phenotypes2 Rosa26 is ubiquitously expressed in embryonic as well as adult tissues3 Targeting genes to the Rosa26 locus is a desirable method to create transgenic animals consistently expressing foreign genes at a high level Insertion of a reporter or toxin gene into the Rosa26 locus has been widely used to trace or ablate specific cell lineages4 and this approach plays a fundamental role in understanding cell differentiation in vivo Rosa26 was first identified and targeted in mouse embryonic stem cells ESCs in 1990s3 and then in human ESCs in 20075 With the establishment of rat pluripotent stem cells the Rosa26 locus was also successfully identified and targeted in rats recently6 However Rosa26 has not been tackled in large animals

    Original URL path: http://www.cell-research.com/arts.asp?id=1914 (2016-02-14)
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  • Cell Research
    4 4 2014 505 508 Recurrent mutations at C reactive protein gene promoter SNP position 286 in human cancers Ming Yu Wang 1 Hai Hong Zhou 1 Shi Chao Zhang 1 Feng Hui 1 Wei Zhu 2 Hai Xiang Su 3 Hong Yun Guo 3 Xing Wen Li 3 Shang Rong Ji 1 and Yi Wu 1 4 1 MOE Key Laboratory of Cell Activities and Stress Adaptations School of Life Sciences Lanzhou University Lanzhou Gansu 730000 China 2 The Second Hospital Lanzhou University Lanzhou Gansu 730000 China 3 The Gansu Cancer Hospital Lanzhou 730050 China 4 Key Laboratory of Preclinical Study for New Drugs of Gansu Province Lanzhou University Lanzhou Gansu 730000 China Correspondence Yi Wu Tel Fax 86 931 8914102 E mail wuy lzu edu cn Shang Rong Ji Tel Fax 86 931 8914176 E mail jsr lzu edu cn Genetic alteration and inflammation underlie the development of cancer1 C reactive protein CRP is the most widely used nonspecific marker of inflammation2 whose serum level has been shown to be associated with the risk and prognosis of several types of cancer3 Accumulating evidence supports a role of CRP as a pattern recognition receptor in the innate immunity and

    Original URL path: http://www.cell-research.com/arts.asp?id=1915 (2016-02-14)
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  • Cell Research
    dependent pathway triggering a novel DUOX2 NADPH Oxidase mediated airway antiviral response FREE Karin Fink 1 2 Lydie Martin 1 Esperance Mukawera 1 Stéfany Chartier 1 Xavier De Deken 3 Emmanuelle Brochiero 1 4 Françoise Miot 3 and Nathalie Grandvaux 1 2 1 Centre de Recherche du CHUM CRCHUM Montréal Québec Canada H2X 1P1 2 Department of Biochemistry Faculty of Medicine Université de Montréal Québec Canada H3T 1J4 3 Institut

    Original URL path: http://www.cell-research.com/arts.asp?id=1917 (2016-02-14)
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  • Cell Research
    10 526 Thomson Reuters 2013 Free Sample Issue Submission Advanced Online Publication Current Issue Top 10 VOLUME 24 ISSUE 4 4 2014 510 510 The ubiquitin conjugating enzyme UBE2L3 regulates TNFα induced linear ubiquitination FREE Bishi Fu 1 Shitao Li 1 Lingyan Wang 1 Michael A Berman 1 and Martin E Dorf 1 1 Division of Immunology Department of Microbiology and Immunobiology Harvard Medical School Boston MA 02115 USA 10

    Original URL path: http://www.cell-research.com/arts.asp?id=1918 (2016-02-14)
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  • Cell Research

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    Original URL path: /artsmore1.asp?id=168 (2016-02-14)


  • Cell Research
    VOLUME 24 ISSUE 5 5 2014 511 512 diRNA Ago2 RAD51 complexes at double strand break sites FREE Soichiro Yamanaka 1 and Haruhiko Siomi 1 1 Department of Molecular Biology Keio University School of Medicine Tokyo 160 8582 Japan Correspondence Haruhiko Siomi E mail awa403 z2 keio jp The way in which the DNA damage response signals the presence of DNA lesions and mediates DNA repair has not been fully

    Original URL path: http://www.cell-research.com/arts.asp?id=1919 (2016-02-14)
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