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  • Cell Research
    cells Paul Toran 1 Irina Smolina 2 Harry Driscoll 2 Feng Ding 3 Yingjie Sun 2 Charles R Cantor 4 and Natalia E Broude 1 2 1 Cell Biology Molecular Biology and Biochemistry Program Boston University Boston MA 01225 USA 2 Department of Biomedical Engineering Boston University Boston MA 01225 USA 3 Department of Physics and Astronomy 118 Kinard Lab Clemson University Clemson SC 29634 USA 4 Sequenom Inc 3595 John Hopkins Court San Diego CA 92121 1331 USA Correspondence Natalia E Broude E mail nebroude bu edu Irina Smolina E mail E mail ismolina bu edu Labeling RNA molecules in their physiological environment is still a technological challenge that should be overcome to study kinetics localization and protein interactions of these ubiquitous cellular regulators The only non invasive method applicable for detecting unmodified RNAs in live cells described so far used two RNA binding pumilio proteins directly interacting with RNA that triggered complementation of the split fluorescent protein FP fused to pumilio proteins1 2 To use this as a universal method the pumilio proteins should be subjected to mutagenesis to bind each new target RNA Protein mutagenesis is a time consuming process and it limits application of this approach

    Original URL path: http://www.cell-research.com/arts.asp?id=1959 (2016-02-14)
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  • Cell Research

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    Original URL path: /artsmore1.asp?id=171 (2016-02-14)


  • Cell Research
    Sample Issue Submission Advanced Online Publication Current Issue Top 10 VOLUME 24 ISSUE 8 8 2014 899 900 BETs abet Tam R in ER positive breast cancer FREE Prasanna G Alluri 1 2 Irfan A Asangani 2 4 and Arul M Chinnaiyan 2 3 4 5 6 1 Department of Radiation Oncology University of Michigan Medical School Ann Arbor MI 48109 USA 2 Michigan Center for Translational Pathology University of Michigan Medical School Ann Arbor MI 48109 USA 3 Comprehensive Cancer Center University of Michigan Medical School Ann Arbor MI 48109 USA 4 Department of Pathology University of Michigan Medical School Ann Arbor MI 48109 USA 5 Department of Urology University of Michigan Medical School Ann Arbor MI 48109 USA 6 Howard Hughes Medical Institute University of Michigan Medical School Ann Arbor MI 48109 USA Correspondence Arul M Chinnaiyan Tel 1 734 615 4062 Fax 1 734 615 4055 E mail arul med umich edu Epigenetic modifications such as histone acetylation play a central role in the transcriptional regulation of many oncogenic drivers Accumulating evidence suggests that pharmacological modulation of certain key epigenetic reader proteins such as BRD2 3 4 may serve as an attractive strategy for treatment of many

    Original URL path: http://www.cell-research.com/arts.asp?id=1962 (2016-02-14)
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  • Cell Research
    Publication Current Issue Top 10 VOLUME 24 ISSUE 8 8 2014 901 903 Targeting Th17 cells in immune diseases FREE Chen Dong 1 1 Tsinghua University School of Medicine Beijing 100084 China Correspondence Chen Dong E mail cdonglab hotmail com Last decade has seen quick developments in the understanding of a new type of T lymphocytes Th17 cells This information is benefiting the understanding and treatment of a variety of

    Original URL path: http://www.cell-research.com/arts.asp?id=1963 (2016-02-14)
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  • Cell Research
    FREE Rosa Bernardi 1 and Luca Gianni 2 1 Division of Molecular Oncology San Raffaele Scientific Institute 20132 Milan Italy 2 Department of Medical Oncology San Raffaele Hospital 20132 Milan Italy Correspondence Luca Gianni E mail gianni luca hsr it Triple negative breast cancers TNBC are clinically heterogeneous but mostly aggressive malignancies devoid of expression of the estrogen progesterone and HER2 ERBB2 or NEU receptors Recent evidence shows that basal

    Original URL path: http://www.cell-research.com/arts.asp?id=1964 (2016-02-14)
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  • Cell Research
    2014 906 907 Linking SOX10 to a slow growth resistance phenotype FREE Gao Zhang 1 2 and Meenhard Herlyn 1 2 1 Molecular and Cellular Oncogenesis Program The Wistar Institute Philadelphia PA 19104 USA 2 Melanoma Research Center The Wistar Institute Philadelphia PA 19104 USA Correspondence Meenhard Herlyn E mail herlynm wistar org Slow cycling BRAFV600E melanoma cells are notoriously resistant to standard chemotherapy or targeted therapy but the underlying

    Original URL path: http://www.cell-research.com/arts.asp?id=1965 (2016-02-14)
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  • Cell Research
    University of Illinois College of Medicine 835 South Wolcott Avenue Chicago IL 60612 USA 2 Department of Medicine The University of Illinois College of Medicine 835 South Wolcott Avenue Chicago IL 60612 USA 3 Department of Pathology The University of Illinois College of Medicine 835 South Wolcott Avenue Chicago IL 60612 USA 4 Center for Lung and Vascular Biology The University of Illinois College of Medicine 835 South Wolcott Avenue

    Original URL path: http://www.cell-research.com/arts.asp?id=1966 (2016-02-14)
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  • Cell Research
    911 The soft underbelly of tumor cells FREE Yufeng Shi 1 S Kyun Lim 1 and Luis F Parada 1 1 Department of Developmental Biology University of Texas Southwestern Medical Center Dallas TX 75390 USA Correspondence Luis F Parada E mail luis parada utsouthwestern edu In a recent Cell paper Kitambi and colleagues identify a small molecule Vacquinol 1 that has beneficial effects on a glioblastoma multiforme mouse model by

    Original URL path: http://www.cell-research.com/arts.asp?id=1967 (2016-02-14)
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