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  • Cell Research
    and Cell Biology University of Chinese Academy of Sciences 320 Yue yang Road Shanghai 200031 China 2 Graduate School Institute of Biochemistry and Cell Biology University of Chinese Academy of Sciences 320 Yue yang Road Shanghai 200031 China 3 State Key Laboratory of Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences 320 Yue yang Road Shanghai 200031 China 4 Department of Laboratory Medicine Hua Shan Hospital Fudan University 12 Road Wulumuqi middle Road Shanghai 200040 China 5 Department of Hematology Hua Shan Hospital Fudan University 12 Road Wulumuqi middle Road Shanghai 200040 China 6 Department of Hematology Changzheng Hospital The Second Military Medical University 415 Fengyang Road Shanghai 200003 China 7 Key Laboratory of Nutrition and Metabolism Institute for Nutritional Sciences Shanghai Institutes for Biological Sciences Chinese Academy of Sciences 320 Yue yang Road Shanghai 200031 China 8 Cancer Research Center SIBS Xuhui Central Hospital Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences 320 Yue yang Road Shanghai 200031 China Correspondence Ronggui Hu E mail coryhu sibs ac cn Tao Zhang E mail shmuzt 126 com Zi Chen E mail drchenzi 163 com Global change in protein turnover protein degradome constitutes a central part of cellular responses to intrinsic or extrinsic stimuli However profiling protein degradome remains technically challenging Recently inhibition of the proteasome e g by using bortezomib BTZ has emerged as a major chemotherapeutic strategy for treating multiple myeloma and other human malignancies but systematic understanding of the mechanisms for BTZ drug action and tumor drug resistance is yet to be achieved Here we developed and applied a dual fluorescence based Protein Turnover Assay ProTA to quantitatively profile global changes in human protein degradome upon BTZ induced proteasomal inhibition ProTA and subsequent network analyses delineate potential molecular basis

    Original URL path: http://www.cell-research.com/arts.asp?id=2001 (2016-02-14)
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  • Cell Research
    4 Seung Hyeon Lim 5 Zang Hee Lee 6 Hong Hee Kim 6 and Yang Sook Chun 1 2 1 Department of Biomedical Sciences Seoul National University College of Medicine Seoul 110 799 Republic of Korea 2 Ischemic Hypoxic Disease Institute Seoul National University College of Medicine Seoul 110 799 Republic of Korea 3 Cancer Research Institute Seoul National University College of Medicine Seoul 110 799 Republic of Korea 4 Department of Microbiology and Immunology Seoul National University College of Medicine Seoul 110 799 Republic of Korea 5 Institute for Experimental Animals Seoul National University College of Medicine Seoul 110 799 Republic of Korea 6 Department of Cell and Developmental Biology Seoul National University School of Dentistry Seoul 110 749 Republic of Korea Correspondence Jong Wan Park E mail parkjw snu ac kr Yang Sook Chun E mail chunys snu ac kr Plant homeodomain finger protein 2 PHF2 which contains a plant homeodomain and a Jumonji C domain is an epigenetic regulator that demethylates lysine 9 in histone 3 H3K9me2 On the other hand runt related transcription factor 2 Runx2 plays essential roles in bone development and regeneration Given previous reports that the PHF2 mutation can cause dwarfism in mice and that PHF2 expression is correlated with that of Runx2 in differentiating thymocytes we investigated whether PHF2 regulates Runx2 mediated bone formation Overexpression of PHF2 facilitated bone development in newborn mice and viral shRNA mediated knockdown of PHF2 delayed calvarial bone regeneration in adult rats In primary osteoblasts and C2C12 precursor cells PHF2 enhances osteoblast differentiation by demethylating Runx2 while suppressor of variegation 3 9 homolog 1 SUV39H1 inhibits bone formation by methylating it The PHF2 Runx2 interaction is mediated by the Jumonji C and Runt domains of the two proteins respectively The interaction between Runx2 and osteocalcin promoter is

    Original URL path: http://www.cell-research.com/arts.asp?id=2002 (2016-02-14)
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  • Cell Research
    Cell Biology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences 320 Yueyang Road Shanghai 200031 China 2 Key Laboratory of Nutrition and Metabolism Institute for Nutritional Sciences Shanghai Institutes for Biological Sciences Chinese Academy of Sciences 320 Yueyang Road Shanghai 200031 China 3 CAS MPG Partner Institute for Computational Biology Shanghai Institute for Biological Sciences Chinese Academy of Sciences 320 Yueyang Road Shanghai 200031 China Correspondence Gang Wang Tel 86 21 54921083 E mail gwang sibcb ac cn Mediator complex is a molecular hub integrating signaling transcription factors and RNA polymerase II RNAPII machinery Mediator MED23 is involved in adipogenesis and smooth muscle cell differentiation suggesting its role in energy homeostasis Here through the generation and analysis of a liver specific Med23 knockout mouse we found that liver Med23 deletion improved glucose and lipid metabolism as well as insulin responsiveness and prevented diet induced obesity Remarkably acute hepatic Med23 knockdown in db db mice significantly improved the lipid profile and glucose tolerance Mechanistically MED23 participates in gluconeogenesis and cholesterol synthesis through modulating the transcriptional activity of FOXO1 a key metabolic transcription factor Indeed hepatic Med23 deletion impaired the Mediator and RNAPII recruitment and

    Original URL path: http://www.cell-research.com/arts.asp?id=2003 (2016-02-14)
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  • Cell Research
    Xi Mei Wu 2 Bin Zhou 3 Yan Teng 1 and Xiao Yang 1 1 State Key Laboratory of Proteomics Genetic Laboratory of Development and Diseases Institute of Biotechnology 20 Dongdajie Beijing 100071 2 Department of Pharmacology School of Medicine Zhejiang University Hangzhou Zhejiang 310058 3 Key Laboratory of Nutrition and Metabolism Institute for Nutritional Sciences Shanghai Institutes for Biological Sciences Graduate School of the Chinese Academy of Sciences Chinese Academy of Sciences Shanghai 200031 China Correspondence Guan Yang Tel Fax 86 10 63895937 E mail yogopop3 163 com Yan Teng Tel Fax 86 10 63895937 E mail tengyan0919 163 com Xiao Yang Tel Fax 86 10 63895937 E mail yangx bmi ac cn Endochondral bone formation is largely dependent on cartilage lineage cells The chondrocytes in growth plates continuously undergo a sequential process from proliferation to terminal hypertrophic differentiation1 Once differentiated hypertrophic chondrocytes elicit multiple functions such as determining bone length inducing osteogenesis as well as directing bone mineralization and eventually disappear at the chondro osseous junction The fate of the terminally differentiated hypertrophic chondrocytes is conceptually important for understanding its role in endochondral bone formation It has been debated for decades whether the terminally differentiated hypertrophic chondrocytes die

    Original URL path: http://www.cell-research.com/arts.asp?id=2004 (2016-02-14)
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  • Cell Research
    Ding 5 Yuchao Chen 1 4 Dazhi Jin 6 Yuna Sun 3 Bin Xia 5 Liming Yan 2 and Zhiyong Lou 1 7 1 Structural Biology Laboratory and MOE laboratory of Protein Science School of Medicine and Life Science Tsinghua University Beijing 100084 China 2 Tsinghua Peking Center for Life Sciences Laboratory of Structural Biology School of Medicine Tsinghua University Beijing 100084 China 3 National Laboratory of Macromolecules Institute of Biophysics Chinese Academy of Science Beijing 100101 China 4 Institute of Plant Stress Biology State Key Laboratory of Cotton Biology School of Life Sciences Henan University Kaifeng Henan 475004 China 5 Beijing Nuclear Magnetic Resonance Center College of Chemistry and Molecular Engineering and School of Life Sciences Peking University Beijing 100871 China 6 Zhejiang Provincial Center for Disease Control and Prevention Zhejiang 310051 China 7 Collaborative Innovation Center for Biotherapy State Key Laboratory of Biotherapy and Cancer Center West China Hospital West China Medical School Sichuan University Chengdu Sichuan 610207 China Correspondence Zhiyong Lou E mail louzy xtal tsinghua edu cn Liming Yan E mail yanlm xtal tsinghua edu cn Through production of cyclic di nucleotides as second messengers di nucleotide cyclases in bacteria and more recently in mammalian cells

    Original URL path: http://www.cell-research.com/arts.asp?id=2005 (2016-02-14)
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  • Cell Research
    Kai Feng 1 Ning Ye 1 Gerald A Tuskan 4 Richard Milne 5 Yingnan Chen 1 Zhibing Wan 1 Zefu Wang 2 Wenchun Luo 2 Kun Wang 2 Dongshi Wan 2 Mingxiu Wang 1 Jun Wang 3 Jianquan Liu 2 and Tongming Yin 1 1 The Southern Modern Forestry Collaborative Innovation Center Nanjing Forestry University Nanjing 210037 China 2 State Key Laboratory of Grassland Agro Ecosystem College of Life Science Lanzhou University Lanzhou 730000 China 3 BGI Shenzhen Shenzhen 518083 China 4 Bio Sciences Division Oak Ridge National Laboratory Oak Ridge TN 37831 USA 5 Institute of Molecular Plant Science The University of Edinburgh Daniel Rutherford Building King s Buildings Mayfield Road Edinburgh EH9 3JH UK Correspondence Tongming Yin E mail tmyin njfu edu cn Jianquan Liu E mail liujq lzu edu cn Jun Wang E mail wangj genomics org cn Willows Salix and poplars Populus are known worldwide as woody species with diverse uses1 2 Although these two genera diverged from each other around the early Eocene3 they share numerous traits including the same chromosome number of 2n 38 and the common Salicoid genome duplication with a high macrosynteny4 5 However most willow species flower early in their lives

    Original URL path: http://www.cell-research.com/arts.asp?id=2006 (2016-02-14)
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  • Cell Research

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    Original URL path: /artsmore1.asp?id=176 (2016-02-14)


  • Cell Research
    1279 1279 Sanofi Cell Research outstanding paper award of 2013 FREE Dangsheng Li 1 1 Deputy Editor in Chief Cell Research Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China Correspondence dsli sibs ac cn In this November issue of Cell Research we are proud to announce the winners of the 5th Sanofi Cell Research Outstanding Paper Award which were selected from papers published in the 2013 print issues of Cell Research The 2013 Sanofi Cell Research Outstanding Review Article Award goes to Dr George Daley for his review paper entitled A blueprint for engineering cell fate current technologies to reprogram cell identify 1 which is co authored with Dr Samantha A Morris The winners of the 2013 Sanofi Cell Research Outstanding Research Article Award are Dr Jiahuai Han for his paper entitled Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis 2 and Dr Rudolf Jaenisch for his paper entitled Multiplexed activation of endogenous genes by CRISPR on an RNA guided transcriptional activator system 3 The award consists of a prize of euro 3000 for the Outstanding Review Article Award and euro 5000 for the Outstanding Research Article Award sponsored by Sanofi The three

    Original URL path: http://www.cell-research.com/arts.asp?id=2008 (2016-02-14)
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