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  • Cell Research
    12 2014 1385 1386 Backseat drivers Cargo adaptors and dynactin activate cytoplasmic dynein motility FREE Mark P Dodding 1 1 Randall Division of Cell and Molecular Biophysics King s College London SE1 1UL UK Correspondence Mark P Dodding E mail mark dodding kcl ac uk Control of the activity of the microtubule motor cytoplasmic dynein 1 is essential for its function in intracellular transport A recent paper by McKenney et

    Original URL path: http://www.cell-research.com/arts.asp?id=2024 (2016-02-14)
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  • Cell Research
    Science Institute of Singapore YLL School of Medicine National University of Singapore Singapore 2 Department of Biological Sciences Faculty of Science National University of Singapore Singapore 3 Department of Biochemistry YLL School of Medicine National University of Singapore Singapore 4 Immunology Programme and Department of Microbiology YLL School of Medicine National University of Singapore Singapore 5 Cancer and Stem Cell Biology Duke NUS Graduate Medical School Singapore 6 Neurobiology Programme Life Sciences Institute National University of Singapore Singapore 7 Departments of Pediatrics and Herman B Wells Center for Pediatric Research Indiana University School of Medicine Indianapolis IN 46202 USA 8 Department of Microbiology and Immunology Indiana University School of Medicine Indianapolis IN 46202 USA Correspondence Yongliang Zhang E mail miczy nus edu sg Xin Yuan Fu E mail xin yuan fu nuhs edu sg T helper TH cell subsets such as TH1 and TH17 mediate inflammation in both peripheral tissues and central nervous system Here we show that STAT5 is required for T helper cell pathogenicity in autoimmune neuroinflammation but not in experimental colitis Although STAT5 promotes regulatory T cell generation and immune suppression loss of STAT5 in CD4 T cells resulted in diminished development of experimental autoimmune encephalomyelitis EAE a mouse model of multiple sclerosis Our results showed that loss of encephalitogenic activity of STAT5 deficient autoreactive CD4 T cells was independent of IFN γ or interleukin 17 IL 17 production but was due to the impaired expression of granulocyte macrophage colony stimulating factor GM CSF a crucial mediator of T cell pathogenicity We further showed that IL 7 activated STAT5 promotes the generation of GM CSF producing CD4 T cells which were preferentially able to induce more severe EAE than TH17 or TH1 cells Consistent with GM CSF producing cells being a distinct subset of TH cells the

    Original URL path: http://www.cell-research.com/arts.asp?id=2029 (2016-02-14)
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  • Cell Research
    6 Akimitsu Okamoto 4 5 Chuan He 7 8 Jannie M Rendtlew Danielsen 1 9 Xiu Jie Wang 10 and Yun Gui Yang 1 1 Key Laboratory of Genomic and Precision Medicine Beijing Institute of Genomics Chinese Acaemy of Sciences No 1 7 Beichen West Road Chaoyang District Beijing 100101 China 2 University of Chinese Academy of Sciences 19A Yuquan Road Beijing 100049 China 3 Protein Science Laboratory of the Ministry of Education School of Life Sciences Tsinghua University Qinghuayuan 1 Beijing 100084 China 4 Research Center for Advanced Science and Technology the University of Tokyo 4 6 1 Komaba Meguro ku Tokyo 153 8904 Japan 5 RIKEN Advanced Science Institute 2 1 Hirosawa Wako Saitama 351 0198 Japan 6 Department of Pathology Center for Experimental Animal Research Institute of Basic Medical Sciences Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100005 China 7 Department of Chemical Biology Beijing National Laboratory for Molecular Sciences Synthetic and Functional Biomolecules Center College of Chemistry and Molecular Engineering Peking University Beijing 100871 China 8 Department of Chemistry Institute for Biophysical Dynamics The University of Chicago 929 East 57th Street Chicago IL 60637 USA 9 The Novo Nordisk Foundation Center for Protein Research Ubiquitin Signalling Group Faculty of Health Sciences Blegdamsvej 3b 2200 Copenhagen Denmark 10 Key Laboratory of Genetic Network Biology Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 China Correspondence Yun Gui Yang Tel Fax 86 10 84097642 E mail ygyang big ac cn The role of Fat Mass and Obesity associated protein FTO and its substrate N6 methyladenosine m6A in mRNA processing and adipogenesis remains largely unknown We show that FTO expression and m6A levels are inversely correlated during adipogenesis FTO depletion blocks differentiation and only catalytically active FTO restores adipogenesis Transcriptome analyses in

    Original URL path: http://www.cell-research.com/arts.asp?id=2030 (2016-02-14)
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  • Cell Research
    3 Edward Li 1 Shi Yan Ng 2 Hao Wu 1 2 Jolanta Chmielowiec 1 2 Xin Jiang 1 2 Lei Bu 1 2 3 Ronald A Li 3 6 Chad Cowan 1 2 and Kenneth R Chien 1 2 4 1 Cardiovascular Research Center Massachusetts General Hospital 185 Cambridge Street Boston MA 02114 USA 2 Department of Stem Cell and Regenerative Biology Harvard University and Harvard Medical School 7 Divinity Avenue Cambridge MA 02138 USA 3 Stem Cell Regenerative Medicine Consortium and the Department of Physiology LKS Faculty of Medicine The University of Hong Kong Hong Kong SAR China 4 Department of Cell and Molecular Biology and Medicine Karolinska Institute 171 77 Stockholm Sweden 5 Department of Biochemistry and Molecular Biology University of Georgia Athens GA 30602 USA 6 Center of Cardiovascular Research Mount Sinai School of Medicine New York NY 10029 USA Correspondence Kenneth R Chien E mail kenneth chien ki se The cardiac progenitor cells CPCs in the anterior heart field AHF are located in the pharyngeal mesoderm PM where they expand migrate and eventually differentiate into major cell types found in the heart including cardiomyocytes The mechanisms by which these progenitors are able to expand within the PM microenvironment without premature differentiation remain largely unknown Through in silico data mining genetic loss of function studies and in vivo genetic rescue studies we identified N cadherin and interaction with canonical Wnt signals as a critical component of the microenvironment that facilitates the expansion of AHF CPCs in the PM CPCs in N cadherin mutant embryos were observed to be less proliferative and undergo premature differentiation in the PM Notably the phenotype of N cadherin deficiency could be partially rescued by activating Wnt signaling suggesting a delicate functional interaction between the adhesion role of N cadherin and Wnt

    Original URL path: http://www.cell-research.com/arts.asp?id=2025 (2016-02-14)
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  • Cell Research
    510630 China 2 Key Laboratory for Stem Cells and Tissue Engineering Center for Stem Cell Biology and Tissue Engineering Ministry of Education Sun Yat sen University Guangzhou Guangdong 510080 China 3 Department of Anatomy Zhongshan School of Medicine Sun Yat sen University Guangzhou Guangdong 510080 China 4 Reproductive Medicine Center and Guangdong provincial Key Laborartory of Reproductive Medicine Sun Yat sen University Guangzhou Guangdong 510080 China 5 Department of Histopathology The First Affiliated Hospital Sun Yat sen University Guangzhou Guangdong 510080 China 6 Department of Infertility and Sexual Medicine The Third Affiliated Hospital Sun Yat sen University Guangzhou Guangdong 510630 China 7 Department of Urology The First Affiliated Hospital Sun Yat Sen University Guangzhou Guangdong 510080 China 8 Key Laboratory of Bioengineering Medicine of Guangdong Province Institute of Biomedicine Jinan University Guangzhou Guangdong 510632 China 9 Department of Biochemistry Zhongshan School of Medicine Sun Yat sen University Guangzhou Guangdong 510080 China 10 State key Laboratory of Reproductive Biology Institute of Zoology Chinese Academy of Sciences Beijing 100101 China Correspondence Andy Peng Xiang Tel 86 20 87335822 Fax 86 20 87335858 E mail xiangp mail sysu edu cn The ability to identify and isolate lineage specific stem cells from adult tissues could facilitate cell replacement therapy Leydig cells LCs are the primary source of androgen in the mammalian testis and the prospective identification of stem Leydig cells SLCs may offer new opportunities for treating testosterone deficiency Here in a transgenic mouse model expressing GFP driven by the Nestin Nes promoter we observed Nes GFP cells located in the testicular interstitial compartment where SLCs normally reside We showed that these Nes GFP cells expressed LIFR and PDGFR α but not LC lineage markers We further observed that these cells were capable of clonogenic self renewal and extensive proliferation in vitro and could

    Original URL path: http://www.cell-research.com/arts.asp?id=2032 (2016-02-14)
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  • Cell Research
    structure of a bacterial homologue of SWEET transporters OPEN Jing Wang 1 2 3 Chuangye Yan 1 2 3 Yini Li 1 2 3 Kunio Hirata 4 Masaki Yamamoto 4 Nieng Yan 1 2 3 and Qi Hu 1 2 3 1 State Key Laboratory of Bio membrane and Membrane Biotechnology Tsinghua University Beijing 100084 China 2 Tsinghua Peking Joint Center for Life Sciences Tsinghua University Beijing 100084 China 3 Center for Structural Biology School of Life Sciences and School of Medicine Tsinghua University Beijing 100084 China 4 Advanced Photon Technology Division Research Infrastructure Group SR Life Science Instrumentation Unit 1 1 1 Kouto Sayo cho Sayo gun Hyogo 679 5148 Japan Correspondence Nieng Yan E mail nyan tsinghua edu cn Qi Hu E mail huqi10 tsinghua org cn SWEETs represent a novel family of membrane sugar transporters that have been identified in plants worms and mammals They selectively transport mono or disaccharides across plasma or intracellular membranes and are involved in a number of essential physiological processes1 The functions of SWEETs are best characterized in plants In Arabidopsis thaliana AtSWEET1 4 5 7 8 13 mediate glucose efflux1 AtSWEET11 12 function as sucrose transporters2 and AtSWEET17 permeates fructose3 4

    Original URL path: http://www.cell-research.com/arts.asp?id=2026 (2016-02-14)
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  • Cell Research
    Zhao 1 Jihui Wu 1 and Yunyu Shi 1 1 Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences University of Science and Technology of China Hefei Anhui 230026 China Correspondence Jihui Wu E mail wujihui ustc edu cn Yunyu Shi E mail yyshi ustc edu cn Recent discoveries suggest that N6 methyladenosine m6A modification a prevalent internal modification in eukaryotic RNA is an essential RNA

    Original URL path: http://www.cell-research.com/arts.asp?id=2033 (2016-02-14)
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  • Cell Research
    ISSUE 12 12 2014 1493 1496 Crystal structure of the YTH domain of YTHDF2 reveals mechanism for recognition of N6 methyladenosine Tingting Zhu 1 Ian A Roundtree 2 Ping Wang1 Xiao Wang 3 4 Li Wang 1 Chang Sun 1 Yuan Tian 1 Jie Li 1 Chuan He 3 4 and Yanhui Xu 1 1 Fudan University Shanghai Cancer Center Department of Oncology and Institute of Biomedical Sciences and School of Basic Medical Sciences Shanghai Medical College of Fudan University Shanghai 200032 China 2 Medical Scientist Training Program and Department of Biochemistry and Molecular Biology The University of Chicago Chicago IL 60637 USA 3 Department of Chemistry and Institute for Biophysical Dynamics The University of Chicago Chicago IL 60637 USA 4 Howard Hughes Medical Institute The University of Chicago Chicago IL 60637 USA Correspondence Yanhui Xu E mail xuyh fudan edu cn N6 methyladenosine m6A has been demonstrated to be ubiquitous in several types of eukaryotic RNAs including messenger RNA mRNA transfer RNA tRNA ribosomal RNA rRNA long non coding RNA lncRNA and small nuclear RNA snRNA 1 The recent discoveries of RNA m6A methyltransferase complex METTL3 METTL14 WTAP and demethylases FTO and ALKBH5 prove the reversibility of m6A modification2

    Original URL path: http://www.cell-research.com/arts.asp?id=2034 (2016-02-14)
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