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  • Cell Research

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    Original URL path: /artsmore1.asp?id=178 (2016-02-14)



  • Cell Research
    1 Department of Cell Biology University of Texas Southwestern Medical Center Dallas Texas USA 2 Federal University of Rio de Janeiro Rio de Janeiro Brazil Correspondence Sandra L Schmid E mail sandra schmid utsouthwestern edu Cell migration is a multi step process that involves the coordinated action of signaling networks cytoskeletal dynamics and vesicular trafficking leading to protrusion and adhesion at the leading edge of cells and contraction and detachment

    Original URL path: http://www.cell-research.com/arts.asp?id=2049 (2016-02-14)
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  • Cell Research
    Sharon Moshitch Moshkovitz 1 and Gideon Rechavi 1 2 1 Sheba Cancer Research Center Chaim Sheba Medical Center Tel Hashomer 52621 Israel 2 Sackler School of Medicine Tel Aviv University Tel Aviv 69978 Israel Correspondence Gideon Rechavi E mail Gidi Rechavi sheba health gov il Polymorphism of the FTO gene encoding an N 6 methyladenosine m 6 A RNA demethylase was robustly associated with human obesity however the mechanism by

    Original URL path: http://www.cell-research.com/arts.asp?id=2050 (2016-02-14)
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  • Cell Research
    FREE Christopher G Langendorf 1 and Bruce E Kemp 1 1 St Vincent s Institute Department of Medicine The University of Melbourne 41 Victoria Parade Fitzroy Victoria 3065 Australia Correspondence Bruce E Kemp E mail bkemp svi edu au A recent study published in Cell Research by Li and colleagues reports a detailed biophysical and structural study of AMPK s intra molecular interactions during activation By employing subunit tagging and

    Original URL path: http://www.cell-research.com/arts.asp?id=2035 (2016-02-14)
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  • Cell Research
    FREE Li Yuan 1 and Venkatesan Sundaresan 1 2 1 Department of Plant Biology University of California Davis Davis CA 95616 USA 2 Department of Plant Biology and Plant Sciences University of California Davis Davis CA 95616 USA Correspondence Venkatesan Sundaresan E mail sundar ucdavis edu Plant reproduction is initiated by the specification of sporocytes that form haploid spores through meiosis A new study in Arabidopsis published in Cell Research

    Original URL path: http://www.cell-research.com/arts.asp?id=2036 (2016-02-14)
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  • Cell Research
    DNA damage response Alexandre Maréchal 1 and Lee Zou 1 2 1 Massachusetts General Hospital Cancer Center Harvard Medical School Charlestown MA 02129 USA 2 Department of Pathology Massachusetts General Hospital Harvard Medical School Boston MA 02114 USA Correspondence Alexandre Maréchal E mail amarechal mgh harvard edu Lee Zou E mail zou lee mgh harvard edu The Replication Protein A RPA complex is an essential regulator of eukaryotic DNA metabolism RPA avidly binds to single stranded DNA ssDNA through multiple oligonucleotide oligosaccharide binding folds and coordinates the recruitment and exchange of genome maintenance factors to regulate DNA replication recombination and repair The RPA ssDNA platform also constitutes a key physiological signal which activates the master ATR kinase to protect and repair stalled or collapsed replication forks during replication stress In recent years the RPA complex has emerged as a key target and an important regulator of post translational modifications in response to DNA damage which is critical for its genome guardian functions Phosphorylation and SUMOylation of the RPA complex and more recently RPA regulated ubiquitination have all been shown to control specific aspects of DNA damage signaling and repair by modulating the interactions between RPA and its partners Here we

    Original URL path: http://www.cell-research.com/arts.asp?id=2037 (2016-02-14)
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  • Cell Research
    1 Ying Li 1 Junya Peng 1 Danni Wu 1 Xiaoxin Zhao 1 Yitong Cui 1 Lilian Chen 1 Xiaojun Yan 2 Yanan Du 2 3 and Li Yu 1 1 State Key Laboratory of Biomembrane and Membrane Biotechnology Tsinghua University Peking University Joint Center for Life Sciences School of Life Science Beijing 100084 China 2 Department of Biomedical Engineering School of Medicine Tsinghua University Beijing 100084 China 3 Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases Hangzhou Zhejiang 310003 China Correspondence Li Yu E mail liyulab mail tsinghua edu cn Cells communicate with each other through secreting and releasing proteins and vesicles Many cells can migrate In this study we report the discovery of migracytosis a cell migration dependent mechanism for releasing cellular contents and migrasomes the vesicular structures that mediate migracytosis As migrating cells move they leave long tubular strands called retraction fibers behind them Large vesicles which contain numerous smaller vesicles grow on the tips and intersections of retraction fibers These fibers which connect the vesicles with the main cell body eventually break and the vesicles are released into the extracellular space or directly taken up by surrounding cells Since the formation of these vesicles

    Original URL path: http://www.cell-research.com/arts.asp?id=2038 (2016-02-14)
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  • Cell Research
    Chen 1 Hua Wang 3 Junfeng Zhang 1 Hualan Chen 2 Ke Zen 1 and Chen Yu Zhang 1 1 Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology State Key Laboratory of Pharmaceutical Biotechnology School of Life Sciences Nanjing University Nanjing Jiangsu 210093 China 2 State Key Laboratory of Veterinary Biotechnology Harbin Veterinary Research Institute Chinese Academy of Agricultural Sciences Harbin Heilongjiang 150001 China 3 Jiangsu Provincial Center for Disease Control and Prevention Nanjing Jiangsu 210090 China Correspondence Chen Yu Zhang E mail cyzhang nju edu cn Ke Zen E mail kzen nju edu cn Hualan Chen E mail chenhualan caas cn Junfeng Zhang E mail jfzhang nju edu cn Hua Wang E mail hua jscdc cn Influenza A viruses IAVs particularly H1N1 H5N1 and H7N9 pose a substantial threat to public health worldwide Here we report that MIR2911 a honeysuckle HS encoded atypical microRNA directly targets IAVs with a broad spectrum MIR2911 is highly stable in HS decoction and continuous drinking or gavage feeding of HS decoction leads to a significant elevation of the MIR2911 level in mouse peripheral blood and lung Bioinformatics prediction and a luciferase reporter assay showed that MIR2911 could target various IAVs including H1N1 H5N1 and H7N9 Synthetic MIR2911 significantly inhibited H1N1 encoded PB2 and NS1 protein expression but did not affect mutants in which the MIR2911 binding nucleotide sequences were altered Synthetic MIR2911 extracted RNA from HS decoction and HS decoction all significantly inhibited H1N1 viral replication and rescued viral infection induced mouse weight loss but did not affect infection with a mutant virus in which the MIR2911 binding nucleotide sequences of PB2 and NS1 were altered Importantly the inhibitory effect of HS decoction on viral replication was abolished by an anti MIR2911 antagomir indicating that the physiological concentration of MIR2911 in HS

    Original URL path: http://www.cell-research.com/arts.asp?id=2039 (2016-02-14)
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