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  • Cell Research
    1 1 2015 148 148 Manipulation of a VEGF Notch signaling circuit drives formation of functional vascular endothelial progenitors from human pluripotent stem cells FREE Makoto Sahara1 2 3 4 Emil M Hansson1 2 Oliver Wernet5 Kathy O Lui1 2 3 Daniela Später1 2 3 and Kenneth R Chien1 2 4 1Department of Stem Cell and Regenerative Biology Harvard University 7 Divinity Avenue Cambridge MA 02138 USA 2Harvard Stem Cell Institute Harvard University 7 Divinity Avenue Cambridge MA 02138 USA 3Center for Regenerative Medicine Massachusetts General Hospital 185 Cambridge Street Boston MA 02114 USA 4Department of Medicine Cardiology Cell and Molecular Biology Karolinska Institutet SE 171 77 Stockholm Sweden 5Department of Anesthesiology and Intensive Care Medicine Charité University Medicine Berlin Campus Charité Mitte Charitéplatz 1 10117 Berlin Germany The protocol in the current study was developed using BIO as the GSK 3β inhibitor and works with other inhibitors as well The strength and specificity of inhibition can increase efficiency of Phase I The authors apologize for the mistyped GSK 3β inhibitor that was used in these studies We would like to correct this immediately which is noted only in three sentences in separate places in the paper This does not

    Original URL path: http://www.cell-research.com/arts.asp?id=2051 (2016-02-14)
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  • Cell Research

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    Original URL path: /artsmore1.asp?id=179 (2016-02-14)


  • Cell Research
    1 Youssef Aachoui 1 and Edward Axel Miao 1 1 Department of Microbiology and Immunology and Lineberger Comprehensive Cancer Center University of North Carolina at Chapel Hill Chapel Hill NC 27599 USA Correspondence Edward Axel Miao E mail emiao med unc edu Inflammasomes are sensors that serve as activation platforms for caspase 1 a mechanism that set the prevailing paradigm for inflammatory caspase activation A recent Nature paper by Shi

    Original URL path: http://www.cell-research.com/arts.asp?id=2052 (2016-02-14)
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  • Cell Research
    1 Program in Neurosciences and Mental Health The Hospital for Sick Children Toronto Ontario M5G 1X8 Canada 2 Institute of Medical Science University of Toronto Toronto Ontario M5S 1A8 Canada 3 Department of Psychology University of Toronto Toronto Ontario M5S 3GM Canada 4 Department of Physiology University of Toronto Toronto Ontario M5S 1A8 Canada Correspondence Paul W Frankland E mail paul frankland sickkids ca Transcription is a highly regulated process

    Original URL path: http://www.cell-research.com/arts.asp?id=2053 (2016-02-14)
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  • Cell Research
    153 154 Pseudouridine in a new era of RNA modifications FREE Boxuan Simen Zhao 1 and Chuan He 1 1 Department of Chemistry and Institute for Biophysical Dynamics Howard Hughes Medical Institute 929 East 57th Street The University of Chicago Chicago IL 60637 USA Correspondence Chuan He E mail chuanhe uchicago edu Two articles recently published in Nature and Cell report the first transcriptome wide maps of pseudouridine Ψ at

    Original URL path: http://www.cell-research.com/arts.asp?id=2054 (2016-02-14)
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  • Cell Research
    155 156 Adenosine activates thermogenic adipocytes FREE Amy K Rines 1 Francisco Verdeguer 1 and Pere Puigserver 1 1 Department of Cancer Biology Dana Farber Cancer Institute and Department of Cell Biology Harvard Medical School Boston MA 02215 USA Correspondence Pere Puigserver E mail pere puigserver dfci harvard edu Brown or beige fat activation can cause potent anti obesity and anti diabetic effects In a study recently published in Nature

    Original URL path: http://www.cell-research.com/arts.asp?id=2055 (2016-02-14)
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  • Cell Research
    University Beijing 100871 China 2 School of Bioscience and Biotechnology South China University of Technology Guangzhou Guangdong 510006 China 3 Department of Microbial Pathogenesis University of Maryland Dental School Baltimore Maryland 21201 USA Correspondence Wensheng Wei Tel 86 10 6275 7227 Fax 86 10 6275 7131 E mail wswei pku edu cn As a gram positive spore forming anaerobic bacillus Clostridium difficile C difficile is responsible for severe and fatal pseudomembranous colitis and poses the most urgent antibiotic resistance threat worldwide Epidemic C difficile is the leading cause of antibiotic associated diarrhoea globally especially diarrhoea due to the emergence of hypervirulent strains associated with high mortality and morbidity TcdB one of the key virulence factors secreted by this bacterium enters host cells through a poorly understood mechanism to elicit its pathogenic effect Here we report the first identification of the TcdB cellular receptor chondroitin sulfate proteoglycan 4 CSPG4 CSPG4 was initially isolated from a whole genome human shRNAmir library screening and its role was confirmed by both TALEN and CRISPR Cas9 mediated gene knockout in human cells CSPG4 is critical for TcdB binding to the cell surface inducing cytoskeleton disruption and cell death A direct interaction between the N terminus

    Original URL path: http://www.cell-research.com/arts.asp?id=2056 (2016-02-14)
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  • Cell Research
    Hongkui Deng 1 6 7 1 The MOE Key Laboratory of Cell Proliferation and Differentiation College of Life Sciences Peking Tsinghua Center for Life Sciences Peking University Beijing 100871 China 2 Academy for Advanced Interdisciplinary Studies Peking University Beijing 100871 China 3 Key Laboratory of Genomic and Precision Medicine Beijing Institute of Genomics Chinese Academy of Sciences Beijing 100101 China 4 University of Chinese Academy of Sciences Beijing 100049 China 5 Beijing Vitalstar Biotechnology Co Ltd Beijing 100012 China 6 Shenzhen Stem Cell Engineering Laboratory Key Laboratory of Chemical Genomics Peking University Shenzhen Graduate School Shenzhen Guangdong 518055 China 7 Peking University Stem Cell Research Center Department of Cell Biology School of Basic Medical Sciences Peking University Health Science Center Beijing 100191 China Correspondence Hongkui Deng E mail hongkui deng pku edu cn Yingli Sun E mail sunyl big ac cn Members of the GATA protein family play important roles in lineage specification and transdifferentiation Previous reports show that some members of the GATA protein family can also induce pluripotency in somatic cells by substituting for Oct4 a key pluripotency associated factor However the mechanism linking lineage specifying cues and the activation of pluripotency remains elusive Here we report that all GATA family members can substitute for Oct4 to induce pluripotency We found that all members of the GATA family could inhibit the overrepresented ectodermal lineage genes which is consistent with previous reports indicating that a balance of different lineage specifying forces is important for the restoration of pluripotency A conserved zinc finger DNA binding domain in the C terminus is critical for the GATA family to induce pluripotency Using RNA seq and ChIP seq we determined that the pluripotency related gene Sall4 is a direct target of GATA family members during reprogramming and serves as a bridge linking the

    Original URL path: http://www.cell-research.com/arts.asp?id=2057 (2016-02-14)
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