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  • Cell Research
    Institute of Genetics and Developmental Biology Beijing 100101 China 2 CAS Center for Excellence in Brain Science Chinese Academy of Sciences Beijing 100101 China 3 State Key Laboratory of Biomembrane and Membrane Biotechnology School of Life Sciences Beijing 100871 China 4 PKU IDG McGovern Institute for Brain Research Peking University Beijing 100871 China 5 School of Life Sciences University of Science and Technology of China Hefei Anhui 230026 China 6 University of Chinese Academy of Sciences Beijing 100039 China Correspondence Jia Jia Liu Tel 86 010 6480 6561 E mail jjliu genetics ac cn Dendritic spines are actin rich membrane protrusions that are the major sites of excitatory synaptic input in the mammalian brain and their morphological plasticity provides structural basis for learning and memory Here we report that endophilin A1 with a well established role in clathrin mediated synaptic vesicle endocytosis at the presynaptic terminal also localizes to dendritic spines and is required for spine morphogenesis synapse formation and synaptic function We identify p140Cap a regulator of cytoskeleton reorganization as a downstream effector of endophilin A1 and demonstrate that disruption of their interaction impairs spine formation and maturation Moreover we demonstrate that knockdown of endophilin A1 or p140Cap impairs

    Original URL path: http://www.cell-research.com/arts.asp?id=2089 (2016-02-14)
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  • Cell Research
    Reuters 2013 Free Sample Issue Submission Advanced Online Publication Current Issue Top 10 VOLUME 25 ISSUE 4 4 2015 517 520 Detection of dietary plant based small RNAs in animals Jian Yang 1 Lisa M Farmer 1 Abia AA Agyekum 1 and Kendal D Hirschi 1 1 USDA ARS Children s Nutrition Research Center Baylor College of Medicine 1100 Bates Street Houston TX 77030 USA Correspondence Kendal Hirschi E mail

    Original URL path: http://www.cell-research.com/arts.asp?id=2090 (2016-02-14)
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  • Cell Research
    4 2015 521 524 A novel chemopreventive strategy based on therapeutic microRNAs produced in plants OPEN Sizolwenkosi Mlotshwa 1 Gail J Pruss 1 John L MacArthur 1 Matthew W Endres 1 Celestia Davis 1 Lorne J Hofseth 2 Maria Marjorette Peña 1 and Vicki Vance 1 1 Department of Biological Sciences University of South Carolina Columbia SC 29208 USA 2 Department of Drug Discovery and Biomedical Sciences South Carolina College

    Original URL path: http://www.cell-research.com/arts.asp?id=2091 (2016-02-14)
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  • Cell Research
    National Center for Protein Science Shanghai Shanghai Key Laboratory of Molecular Andrology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China 2 Department of Embryology Carnegie Institution for Science Baltimore MD 21218 USA 3 National Laboratory of Biomacromolecules Chinese Academy of Sciences Beijing 100101 China 4 State Key Laboratory of Genetic Engineering Collaborative Innovation Center of Genetics and Development Department of

    Original URL path: http://www.cell-research.com/arts.asp?id=2092 (2016-02-14)
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  • Cell Research

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    Original URL path: /artsmore1.asp?id=128 (2016-02-14)


  • Cell Research
    Way Rockville MD In any multi cellular organism the balance between cell division and cell death maintains a constant cell number Both cell division cycle and cell death are highly regulated events Whether the cell will proceed through the cycle or not depends upon whether the conditions required at the checkpoints during the cycle are fulfilled In higher eucaryotic cells such as mammalian cells signals that arrest the cycle usually

    Original URL path: http://www.cell-research.com/arts.asp?id=1444 (2016-02-14)
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  • Cell Research
    vertebrates are good experimental models for studies of cell and developmental biology by many favorable characteristics Nuclear transplantation in fish has been thoroughly studied in China since 1960s Fish nuclei of embryonic cells from different genera were transplanted into enucleated eggs generating nucleo cytoplasmic hybrids of adults Most importantly nuclei of cultured goldfish kidney cells had been reprogrammed in enucleated eggs to support embryogenesis and ontogenesis of a fertile fish This was the first case of cloned fish with somatic cells Based on the technique of microinjection recombinant MThGH gene has been transferred into fish eggs and the first batch of transgenic fish were produced in 1984 The behavior of foreign gene was characterized and the onset of the foreign gene replication occurred between the blastula to gastrula stages and random integration mainly occurred at later stages of embryogenesis This eventually led to the transgenic mosaicism The MThGH transferred common carp enhanced growth rate by 2 4 times in the founder juveniles and doubled the body weight in the adults The transgenic common carp were more efficient in utilizing dietary protein than the controls An all fish gene construct CAgcGH has been made by splicing the common carp β actin

    Original URL path: http://www.cell-research.com/arts.asp?id=1445 (2016-02-14)
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  • Cell Research
    Institute of Plant Physiology Chinese Academy of Sciences 300 Fenglin Road Shanghai 200032 BcpCAL the homologous gene of CAL was isolated from Chinese cabbage Unlike BobCAL of cauliflower BcpCAL did not hold the terminating mutation in the fifth exon After crosses of cauliflower with Chinese cabbage the resultant hybrids failed to form curd which implicates the genetic complement of BcpCAL to the mutated BobCAL in the function of curd formation

    Original URL path: http://www.cell-research.com/arts.asp?id=1446 (2016-02-14)
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