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  • Cell Research
    Top 10 VOLUME 10 ISSUE 2 6 2000 139 149 Activation of phospholipase D activity in transforming growth factor beta induced cell growth inhibition ZHOU Bing Hong Jun Song CHEN Ming Qiang CHAI Sheng ZHAO Jun LIANG He Hua CHEN Jian Guo SONG State Key Laboratory of Molecular Biology Shanghai Institute of Biochemistry Chinese Academy of Sciences 320 Yue Yang Road Shanghai 200031 China Cells regulate phospholipase D PLD activity in response to numerous extracellular signals Here we investigated the involvement of PLD activity in transforming growth factor b TGF b 1 mediated growth inhibition of pithelial cells TGF b inhibits the growth of MDCK Mv1Lu and A 549 cells In the presence of 0 4 butanol TGF b induces an increase in the formation of phosphatidylbutanol a unique product catalyzed by PLD TGF b also induces an increase in phosphatidic acid PA level in A 549 and MDCK cells TGF b induces an increase in the levels of DAG labeled with 3 H myristic acid in A 549 and MDCK cells but not in Mv1Lu cells No increase of DAG was observed in cells prelabeled with 3 H arachidonic acid The data presented suggest that PLD activation is involved

    Original URL path: http://www.cell-research.com/arts.asp?id=1442 (2016-02-14)
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  • Cell Research
    151 160 Leafy head formation of the progenies of transgenic plants of Chinese cabbage with exogenous auxin genes HE Yu Ke Wan Xin XUE Yu Dong SUN Xu Hong YU Ping Lin LIU National Laboratory of Plant Molecular Genetics Shanghai Institute of Plant Physiology Chinese Academy of Sciences Shanghai 200032 China The experiment was performed to evaluate the progenies of plant lines transgenic for auxin synthesis genes derived from Ri T DNA Four lines of the transgenic plants were self crossed and the foreign auxin genes in plants of T5 generation were confirmed by Southern hybridization Two lines D1232 and D1653 showed earlier folding of expanding leaves than untransformed line and therefore had early initiation of leafy head Leaf cuttings derived from plant of transgenic line D1653 produced more adventitious roots than the control whereas the cuttings from folding leaves had much more roots than rosette leaves at folding stage and the cuttings from head leaves had more roots than rosette leaves at heading stage It is demonstrated that early folding of transgenic leaf may be caused by the relatively higher concentration of auxin These plant lines with auxin transgenes can be used for the study of hormonal regulation in

    Original URL path: http://www.cell-research.com/arts.asp?id=1443 (2016-02-14)
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  • Cell Research

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    Original URL path: /artsmore1.asp?id=126 (2016-02-14)


  • Cell Research
    Online Publication Current Issue Top 10 VOLUME 10 ISSUE 3 9 2000 161 167 Signal transduction mediated by Bid a pro death Bcl 2 family proteins connects the death receptor and mitochondria apoptosis pathways YIN Xiao Ming Department of Pathology University of Pittsburgh School of Medicine 3550 Terrace Street Pittsburgh PA 15261 USA Two major apoptosis pathways have been defined in mammalian cells the Fas TNF R1 death receptor pathway and the mitochondria pathway The Bcl 2 family proteins consist of both anti apoptosis and pro apoptosis members that regulate apoptosis mainly by controlling the release of cytochrome c and other mitochondrial apoptotic events However death signals mediated by Fas TNF R1 receptors can usually activate caspases directly bypassing the need for mitochondria and escaping the regulation by Bcl 2 family proteins Bid is a novel pro apoptosis Bcl 2 family protein that is activated by caspase 8 in response to Fas TNF R1 death receptor signals Activated Bid is translocated to mitochondria and induces cytochrome c release which in turn activates downstream caspases Such a connection between the two apoptosis pathways could be important for induction of apoptosis in certain types of cells and responsible for the pathogenesis of

    Original URL path: http://www.cell-research.com/arts.asp?id=1429 (2016-02-14)
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  • Cell Research
    ISSUE 3 9 2000 169 177 The IAP family endogenous caspase inhibitors with multiple biological activities YANG Yi Li Xiao Ming LI Laboratory of Immune Cell Biology Division of Basic Sciences National Cancer Institute National Institutes of Health Bethesda MD 20892 USA IAPs inhibitors of apoptosis are a family of proteins containing one or more characteristic BIR domains These proteins have multiple biological activities that include binding and inhibiting caspases regulating cell cycle progression and modulating receptor mediated signal transduction Our recent studies found the IAP family members XIAP and c IAP1 are ubiquitinated and degraded in proteasomes in response to apoptotic stimuli in T cells and their degradation appears to be important for T cells to commit to death In addition to three BIR domains each of these IAPs also contains a RING finger domain We found this region confers ubiquitin protease ligase E3 activity to IAPs and is responsible for the auto ubiquitination and degradation of IAPs after an apoptotic stimulus Given the fact that IAPs can bind a variety of proteins such as caspases and TRAFs it will be of interest to characterize potential substrates of the E3 activity of IAPs and the effects of ubiquitination by

    Original URL path: http://www.cell-research.com/arts.asp?id=1430 (2016-02-14)
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  • Cell Research
    2013 Free Sample Issue Submission Advanced Online Publication Current Issue Top 10 VOLUME 10 ISSUE 3 9 2000 179 192 Activation induced cell death in B lymphocytes DONJERKOVIĆ Dubravka David W SCOTT Department of Immunology Holland Laboratory for the Biomedical Sciences American Red Cross 15601 Crabbs Branch Way Rockville MD 20855 USA Upon encountering the antigen Ag the immune system can either develop a specific immune response or enter a specific state of unresponsiveness tolerance The response of B cells to their specific Ag can be activation and proliferation leading to the immune response or anergy and activation induced cell death AICD leading to tolerance AICD in B lymphocytes is a highly regulated event initiated by crosslinking of the B cell receptor BCR BCR engagement initiates several signaling events such as activation of PLCρ Ras and PI3K which generally speaking lead to survival However in the absence of survival signals CD40 or IL 4R engagement BCR crosslinking can also promote apoptotic signal transduction pathways such as activation of effector caspases expression of pro apoptotic genes and inhibition of pro survival genes The complex interplay between survival and death signals determines the B cell fate and consequently the immune response keywords

    Original URL path: http://www.cell-research.com/arts.asp?id=1431 (2016-02-14)
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  • Cell Research
    20742 USA 2 Department of Biology University of Maryland College Park Maryland 20742 USA Programmed cell death plays an important role in maintaining homeostasis during animal development and has been conserved in animals as different as nematodes and humans Recent studies of Drosophila have provided valuable information toward our understanding of genetic regulation of death Different signals trigger the novel death regulators rpr hid and grim that utilize the evolutionarily

    Original URL path: http://www.cell-research.com/arts.asp?id=1432 (2016-02-14)
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  • Cell Research
    Shao Bai XUE Department of Biology Beijing Normal University Beijing 100875 China Apoptosis manifests in two major execution programs downstream of the death signal the caspase pathway and organelle dysfunction An important antiapoptosis factor Bcl 2 protein contributes in caspase pathway of apoptosis Calcium an important intracellular signal element in cells is also observed to have changes during apoptosis which maybe affected by Bcl 2 protein We have previously reported that in Harringtonine HT induced apoptosis of HL 60 cells there s a change of intracellular calcium distribution moving from cytoplast especially Golgi s apparatus to nucleus and accumulating there with the highest concentration We report here that caspase 3 becomes activated in HT induced apoptosis of HL 60 cells which can be inhibited by overexpression of Bcl 2 protein No sign of apoptosis or intracellular calcium movement from Golgi s apparatus to nucleus in HL 60 cells overexpressing Bcl 2 or treated with Ac DEVD CHO a specific inhibitor of caspase 3 The results indicate that activated caspase 3 can promote the movement of intracellular calcium from Golgi s apparatus to nucleus and the process is inhibited by Ac DEVD CHO inhibitor of caspase 3 and that Bcl 2

    Original URL path: http://www.cell-research.com/arts.asp?id=1434 (2016-02-14)
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