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  • Cell Research
    into egg extracts of Xenopus laevis they caused nuclei of mouse liver to undergo apoptotic changes Chromatin condensation margination and DNA ladder were observed After incubating isolated mitochondria in some hypotonic solutions and centrifuging these mixtures at high speed we got mitochondrial supernatants It was found that in the absence of cytosolic factor the supernatant alone was able to induce apoptotic changes in nuclei The effective components were partly of

    Original URL path: http://www.cell-research.com/arts.asp?id=1435 (2016-02-14)
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  • Cell Research
    233 242 Mitochondria supernatant apoptosis egg extract nuclei DNA cleavage CHANG Yun Chao Yong Hua XU Shanghai Institute of Cell Biology Chinese Academy of Sciences 320 Yue yang Road Shanghai 200031 China Apoptosis plays an important role in embryonic development tissue remodeling immune regulation and tumor regression Two groups of molecules Bcl 2 family and Death factor family are involved in regulating apoptosis In order to know about the effect of Bcl 2 on apoptosis induced by Fas a typical member of Death factor family the transfection experiments with expression vectors pcDNA3 fl and pcDNA3 bcl 2 were performed in BEL 7404 cells a human hepatocellular carcinoma cell line which expresses endogenous Fas but not FasL and Bcl 2 The data showed that the expression of FasL in pcDNA3 fl transfected hepatoma cells obviously induced the apoptosis of the cells However the overexpression of Bcl 2 in pcDNA3 bcl 2 transfected 7404 b 16 cells counteracted pcDNA3 fl transient transfection mediated apoptosis Further study by co transfection experiments indicated that Bid but not Bax both were pro apoptotic proteins of Bcl 2 family blocked the inhibitory effect of Bcl 2 on Fas mediated apoptosis These results suggested that Fas mediated

    Original URL path: http://www.cell-research.com/arts.asp?id=1436 (2016-02-14)
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  • Cell Research

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    Original URL path: /artsmore1.asp?id=125 (2016-02-14)


  • Cell Research
    MA USA Apoptosis produced in B cells through Fas APO 1 CD95 triggering is regulated by signals derived from other surface receptors CD40 engagement produces upregulation of Fas expression and marked susceptibility to Fas induced cell death whereas antigen receptor engagement or IL 4R engagement inhibits Fas killing and in so doing induces a state of Fas resistance even in otherwise sensitive CD40 stimulated targets Surface immunoglobulin and IL 4R utilize at least partially distinct pathways to produce Fas resistance that differentially depend on PKC and STAT6 respectively Further surface immunoglobulin signaling for inducible Fas resistance bypasses Btk requires NF κB and entails new macromolecular synthesis Terminal effectors of B cell Fas resistance include the known anti apoptotic gene products Bcl x L and FLIP and a novel anti apoptotic gene that encodes FAIM Fas Apoptosis Inhibitory Molecule faim was identified by differential display and exists in two alternatively spliced forms faim S is broadly expressed but faim L expression is tissue specific The FAIM sequence is highly evolutionarily conserved suggesting an important role for this molecule throughout phylogeny Inducible resistance to Fas killing is hypothesized to protect foreign antigen specific B cells during potentially hazardous interactions with FasL bearing

    Original URL path: http://www.cell-research.com/arts.asp?id=1422 (2016-02-14)
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  • Cell Research
    Amgen Institute and Ontario Cancer Institute Departments of Immunology and Medical Biophysics University of Toronto Canada Apoptosis or programmed cell death PCD is an evolutionarily conserved cellular process that is essential for normal development and homeostasis of multicellular organisms Defects in the apoptosis signaling result in many diseases including autoimmune diseases and cancer The apoptosis signaling pathway was first described genetically in the nematode Caenorhabditis elegans which serves as a

    Original URL path: http://www.cell-research.com/arts.asp?id=1423 (2016-02-14)
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  • Cell Research
    Red Cross Rockville Department of Anatomy and Cell Biology George Washington University School of Medicine and Health Sciences Washington DC Cellular biological activities are tightly controlled by intracellular signaling processes initiated by extracellular signals Protein tyrosine phosphatases which remove phosphate groups from tyrosine phosphorylated signaling molecules play equally important tyrosine roles as protein kinases in signal transduction SHP 2 a cytoplasmic SH2 domain containing protein tyrosine phosphatase is involved in

    Original URL path: http://www.cell-research.com/arts.asp?id=1424 (2016-02-14)
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  • Cell Research
    GU 1 Ji Ning LU 1 Jia Ke TSO 1 1 Shanghai Institute of Planned Parenthood Research Shanghai 200032 China 2 College of Life Science Shandong University Jinan 250100 China p34 cdc2 and Cyclin B1 are key components of cell cycle controlling machine and are believed to play a fundamental role in gametogenesis It is also well known that in scrotal mammals spermatogenesis depends greatly on the maintenance of comparatively low temperature in the scrotum To investigate whether the expression of cdc2 and cyclin B1 in spermatogenic cells during spermatogenesis is actually a temperature dependent event in situ hybridization Western blotting and immunohistochemistry analysis were used to study the expression of cdc2 and cyclin B1 in normal and cryptorchid testis Results showed that the abdominal temperature had no significant influence on the transcription of cdc2 and cyclin B1 in the spermatogonia and pachytene diplotene primary spermatocytes but it blocked the translation of them Due to the deficiency of p34 cdc2 and Cyclin B1 the spermatogonia and pachytene diplotene primary spermatocytes were unable to form MPF hence they couldn t undergo karyokinesis The development of primary spermatocytes was arrested at the G2 to M phase transition We also found that testosterone

    Original URL path: http://www.cell-research.com/arts.asp?id=1425 (2016-02-14)
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  • Cell Research
    Zhen Tong MEI 2 Jian FEI 1 Li He GUO 1 1 Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Science Shanghai 200031 China 2 Shanghai Institute of Physiology Chinese Academy of Science Shanghai 200031 China Transgenic mice ubiquitously overexpressing murine r aminobutyric acid transporter subtype I were created Unexpectedly these mice markedly exhibited heritable obesity which features significantly increased body weight and fat

    Original URL path: http://www.cell-research.com/arts.asp?id=1426 (2016-02-14)
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