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  • Cell Research

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    Original URL path: /artsmore1.asp?id=117 (2016-02-14)



  • Cell Research
    Building Gower Street UCL London WC1 E 6AU UK 2 Department of Surgery Charles Bell House 67 73 Riding House Street UCL London W1W 7EJ UK Correspondence Weiming XU Tel 442076796209 E mail w xu ucl ac uk Nitric oxide NO is a pleiotropic regulator critical to numerous biological processes including vasodilatation neurotransmission and macrophage mediated immunity The family of nitric oxide synthases NOS comprises inducible NOS iNOS endothelial NOS eNOS and neuronal NOS nNOS Interestingly various studies have shown that all three isoforms can be involved in promoting or inhibiting the etiology of cancer NOS activity has been detected in tumour cells of various histogenetic origins and has been associated with tumour grade proliferation rate and expression of important signaling components associated with cancer development such as the oestrogen receptor It appears that high levels of NOS expression for example generated by activated macrophages may be cytostatic or cytotoxic for tumor cells whereas low level activity can have the opposite effect and promote tumour growth Paradoxically therefore NO and related reactive nitrogen species may have both genotoxic and angiogenic properties Increased NO generation in a cell may select mutant p53 cells and contribute to tumour angiogenesis by upregulating VEGF

    Original URL path: http://www.cell-research.com/arts.asp?id=1337 (2016-02-14)
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  • Cell Research
    Biotechnology Schools of Sciences and Medicine Tsinghua University Beijing 100084 China 2 Center for Animal Transgenesis and Germ Cell Research School of Veterinary Medicine Department of Animal Biology University of Pennsylvania New Bolton Center 382 West Street Road Kennett Square PA 19348 USA 3 Department of Pharmacology University of Minnesota Minneapolis MN 55455 USA Correspondence Duanqing PEI E mail Duanqing aol com Mammalian cell totipotency is a subject that has fascinated scientists for generations A long lasting question whether some of the somatic cells retains totipotency was answered by the cloning of Dolly at the end of the 20th century The dawn of the 21st has brought forward great expectations in harnessing the power of totipotentcy in medicine Through stem cell biology it is possible to generate any parts of the human body by stem cell engineering Considerable resources will be devoted to harness the untapped potentials of stem cells in the foreseeable future which may transform medicine as we know today At the molecular level totipotency has been linked to a singular transcription factor and its expression appears to define whether a cell should be totipotent Named Oct4 it can activate or repress the expression of various genes Curiously

    Original URL path: http://www.cell-research.com/arts.asp?id=1338 (2016-02-14)
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  • Cell Research
    inhibit LPS induced IL 12 p40 expression by interfering with phosphorylation of p38 MAPK in Murine Peritoneal Macrophages Wei Guo FENG Yi Bing WANG Jin Song ZHANG Xing Yu WANG Chang lin LI Zong Liang CHANG Laboratory of Immune Signaling Transduction Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China Correspondence Zong Liang CHANG E mail immusig sunm shcnc ac cn cAMP mediated signaling may play a suppressive role in immune response We previously found that the cAMP elevators CTx and 8 Br cAMP inhibited IL 12 IL 1a IL 6 gene expression but increased the transcriptional levels of IL 10 and IL 1Ra in LPS treated murine peritoneal macrophages The present study examined a possible molecular mechanism involved in cAMP elevators induced inhibition of IL 12 p40 expression in response to LPS Our data demonstrated that cAMP elevators downregulated IL 12 p40 mRNA expression and IL 12 p70 production in murine peritoneal macrophages Subsequent studies revealed that cAMP elevators blocked phosphorylation of p38 MAPK but did not affect the activity of NF kB binding to IL 12 promoter 136 112 This is the first report that cAMP elevators inhibit LPS

    Original URL path: http://www.cell-research.com/arts.asp?id=1339 (2016-02-14)
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  • Cell Research
    XU Da Qin MAO Li Li FU Jian Ren GU Jing De ZHU The State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer Institute Ln 2200 25 Xie Tu Road Shanghai 200032 China Correspondence Jing De ZHU Tel 00 86 21 64224285 E mail zhujingde yahoo com The human C17orf25 gene Accession No AF177342 is one of thirteen genes cloned from a region displaying a high score of loss of heterozygosity within chromosome 17p13 3 in human hepatocellular carcinoma in China 1 To unveil the underlying mechanisms for the transcription regulation of this gene and understand its implication to the hepatocellular carcinogenesis we looked into the relevant aspects by both bioinformatic and experimental executions We found 1 The abundant expression of the C17orf25 gene was evident in all the cell lines and tissue samples tested showing little hepatoma selectivity 2 Its transcription starts at a single site locating at 60 from the translation initiation codon 3 A 58 bp fragment containing the transcription start extending from 112 to 55 represents the minimal promoter 4 The consensus sequence within this fragment recognized by SP1 contributes predominantly to the activity of the minimal promoter 5 The bioinformatic analysis suggests that the

    Original URL path: http://www.cell-research.com/arts.asp?id=1340 (2016-02-14)
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  • Cell Research
    Yueyang Road Shanghai 200031 China 2 Department of Surgery Huashan Hospital Fudan University Shanghai 200031 China 3 Department of Pathology Changzheng Hospital Second Military Medical University Shanghai 200003 China Correspondence Yong Hua XU Tel 0086 21 64711349 E mail yhxu sunm shcnc ac cn Human fibrinogen related protein 1 liver fibrinogen related protein 1 HFREP 1 LFIRE 1 a liver specific protein is a member of fibrinogen superfamily that exerts various biological activities However the function of HFREP 1 LFIRE 1 in liver remains unknown Here we isolated its mouse ortholog gene mouse fibrinogen related protein 1 mfrep 1 which encoded 314 amino acids exhibiting 80 4 similarity to HFREP 1 LFIRE 1 Northern blot analysis revealed that 1 2 kb mfrep 1 mRNA was detected selectively in mouse liver To explore the function of MFREP 1 we examined the levels of mfrep 1 mRNA during regeneration after 70 partial hepatectomy PHx in mice mfrep 1 mRNA increased in the regenerating liver and reached the first shoulder peak at 2 4 h after PHx Cycloheximide pretreatment could suppress the induction of mfrep 1 indicating the up regulation of this gene need de novo protein synthesis Its mRNA continued to elevate

    Original URL path: http://www.cell-research.com/arts.asp?id=1341 (2016-02-14)
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  • Cell Research
    0086 21 64711349 E mail yhxu sunm shcnc ac cn IL 16 is a ligand and chemotactic factor for CD4 T cells IL 16 inhibits the CD3 mediated lymphocyte activation and proliferation The effects of IL 16 on the target cells are dependent on the cell type the presence of co activators etc To understand the regulation function and mechanism of IL 16 on target cells we used a 130 a a recombinant IL 16 to study its effects on the growth of Jurkat T leukemia cells in vitro We found that the rIL 16 stimulated the proliferation of Jurkat cells at low dose 10 9 M but inhibited the growth of the cells at higher concentration 10 5 M Results showed that 10 5 M of rIL 16 treatment induced an enhanced apoptosis in Jurkat cells The treatment blocked the expression of FasL but up regulated the c myc and Bid expression in the cells Pre treatment of PKC inhibitor or MEK1 inhibitor markedly increased or decreased the rIL 16 induced growth inhibiting effects on Jurkat cells respectively The results suggested that the rIL 16 might be a regulator for the growth or apoptosis of Jurkat cells at a

    Original URL path: http://www.cell-research.com/arts.asp?id=1342 (2016-02-14)
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  • Cell Research
    Pathology University of Sydney NSW 2006 Australia 2 Human Reproduction Unit Department of Physiology University of Sydney Royal North Shore Hospital NSW 2065 Australia Correspondence Nicholas JC KING Tel 61 2 9351 4553 E mail nickk pathology usyd edu au Expression of the adhesion molecules ICAM 1 VCAM 1 NCAM CD44 CD49d VLA 4 a chain and CD11a LFA 1 a chain on mouse oocytes and pre and peri implantation stage embryos was examined by quantitative indirect immunofluorescence microscopy ICAM 1 was most strongly expressed at the oocyte stage gradually declining almost to undetectable levels by the expanded blastocyst stage NCAM also expressed maximally on the oocyte declined to undetectable levels beyond the morula stage On the other hand CD44 declined from highest expression at the oocyte stage to show a second maximum at the compacted 8 cell morula This molecule exhibited high expression around contact areas between trophectoderm and zona pellucida during blastocyst hatching CD49d was highly expressed in the oocyte remained significantly expressed throughout and after blastocyst hatching was expressed on the polar trophectoderm Like CD44 CD49d declined to undetectable levels at the blastocyst outgrowth stage Expression of both VCAM 1 and CD11a was undetectable throughout The diametrical

    Original URL path: http://www.cell-research.com/arts.asp?id=1343 (2016-02-14)
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