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  • Cell Research
    12 2003 509 514 Gene expression profile favoring phenotypic reversion a clue for mechanism of tumor suppression by NF IL6 3 UTR Ding Gan LIU 1 Qiu Hong JIANG 1 Yun Yi WEI 1 Li SUN 1 Bei Bei FU 1 Fu Kun ZHAO 2 Qiong ZHOU 1 1 State Key Laboratory of Molecular Biology and 2 Key Laboratory of Proteomics Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China E mail dgliu sibs ac cn Correspondence Ding Gan LIU Tel 021 54921135 E mail dgliu sibs ac cn Transfection of cDNA in 3 untranslated region of human nuclear factor for interleukin 6 NF IL6 3 UTR induced tumor suppression in a human hepatoma cell line cDNA array analysis was used to reveal changes in gene expression profile leading to tumor suppression The results indicate that this suppression was not due to activation of dsRNA dependent protein kinase nor to inactivation of oncogenes rather all the changes in expression of known genes induced by NF IL6 3 UTR cDNA may be ascribed to the suppression of cellular malignancy Therefore our results imply that this 3 untranslated region may have played role

    Original URL path: http://www.cell-research.com/arts.asp?id=1296 (2016-02-14)
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  • Cell Research

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    Original URL path: /artsmore1.asp?id=109 (2016-02-14)


  • Cell Research
    2013 Free Sample Issue Submission Advanced Online Publication Current Issue Top 10 VOLUME 14 ISSUE 1 2 2004 1 7 The revolution of the biology of the genome Wolfgang HENNIG German Academic Exchange Service DAAD Laboratory Shanghai Institutes for Biological Sciences Chinese Academy of Sciences 320 Yue Yang Road Shanghai 200031 China Correspondence Wolfgang HENNIG E mail whennig sibs ac cn Sequence data of entire eukaryotic genomes and their detailed comparison have provided new evidence on genome evolution The major mechanisms involved in the increase of genome sizes are polyploidization and gene duplication Subsequent gene silencing or mutations preferentially in regulatory sequences of genes modify the genome and permit the development of genes with new properties Mechanisms such as lateral gene transfer exon shuffling or the creation of new genes by transposition contribute to the evolution of a genome but remain of relatively restricted relevance Mechanisms to decrease genome sizes and in particular to remove specific DNA sequences such as blocks of satellite DNAs appear to involve the action of RNA interference RNAi RNAi mechanisms have been proven to be involved in chromatin packaging related with gene inactivation as well as in DNA excision during the macronucleus development in ciliates

    Original URL path: http://www.cell-research.com/arts.asp?id=1274 (2016-02-14)
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  • Cell Research
    Sample Issue Submission Advanced Online Publication Current Issue Top 10 VOLUME 14 ISSUE 1 2 2004 8 15 Arabidopsis RAV1 is down regulated by brassinosteroid and may act as a negative regulator during plant development Yu Xin HU Yong Hong WANG Xin Fang LIU Jia Yang LI Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 China Correspondence Jia Yang LI Tel 0086 10 64852855 E mail jyli genetics ac cn RAV1 is a novel DNA binding protein with two distinct DNA binding domains unique in higher plants but its role in plant growth and development remains unknown Using cDNA array we found that transcription of RAV1 is down regulated by epibrassinolide epiBL in Arabidopsis suspension cells RNA gel blot analysis revealed that epiBL regulated RAV1 transcription involves neither protein phosphorylation dephosphorylation nor newly synthesized protein and does not require the functional BRI1 suggesting that this regulation might be through a new BR signaling pathway Overexpressing RAV1 in Arabidopsis results in a retardation of lateral root and rosette leaf development and the underexpression causes an earlier flowering phenotype implying that RAV1 may function as a negative regulatory component of growth and development keywords RAV1 Brassinosteroid signal transduction

    Original URL path: http://www.cell-research.com/arts.asp?id=1275 (2016-02-14)
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  • Cell Research
    of Apoptosis and Cancer Biology State Key Laboratory of Biomembrane and Membrane Biotechnology Chinese Academy of Sciences Beijing 100080 China 2 Cardiovascular Institute and Fu Wai Hospital Peking Union Medical College and Chinese Academy of Medical Sciences Beijing 100037 China Correspondence Quan CHEN Lan Ying CHEN Tel 86 10 6253 7763 86 10 6831 4466 ext 8068 E mail chenq panda ioz ac cn lanyingchen hotmail com Heart remodeling is associated with the loss of cardiomyocytes and increase of fibrous tissue owing to abnormal mechanical load in a number of heart disease conditions In present study a well described in vitro sustained stretch model was employed to study mechanical stretch induced responses in both neonatal cardiomyocytes and cardiac fibroblasts Cardiomyocytes but not cardiac fibroblasts underwent mitochondria dependent apoptosis as evidenced by cytochrome c cyto c and Smac DIABLO release from mitochondria into cytosol accompanied by mitochondrial membrane potential Dy m reduction indicative of mitochondrial permeability transition pore PTP opening Cyclosporin A an inhibitor of PTP inhibited stretch induced cyto c release Dy m reduction and apoptosis suggesting an important role of mitochondrial PTP in stretch induced apoptosis The stretch also resulted in increased expression of the pro apoptotic Bcl 2 family proteins including Bax and Bad in cardiomyocytes but not in fibroblasts Bax was accumulated in mitochondria following stretch Cell permeable Bid BH3 peptide could induce and facilitate stretch induced apoptosis and Dy m reduction in cardiomyocytes These results suggest that Bcl 2 family proteins play an important role in coupling stretch signaling to mitochondrial death machinery probably by targeting to PTP Interestingly the levels of p53 were increased at 12 h after stretch although we observed that Bax upregulation and apoptosis occurred as early as 1 h Adenovirus delivered dominant negative p53 blocked Bax upregulation in cardiomyocytes but showed

    Original URL path: http://www.cell-research.com/arts.asp?id=1276 (2016-02-14)
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  • Cell Research
    Xin ZHANG 1 Bi Zeng MAO 2 Qun LI 1 Zu Hua HE 1 2 1 SHARF and National Laboratory of Plant Molecular Genetics Shanghai Institute of Plant Physiology and Ecology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200032 China 2 Biotechnology Institute Zhejiang University Hangzhou 310029 China Correspondence Zu Hua HE Tel 86 21 64042090 ext 6572 E mail zhe iris sipp ac cn Alpha picolinic acid PA a metabolite of tryptophan and an inducer of apoptosis in the animal cell has been reported to be a toxin produced by some of plant fungal pathogens and used in screening for disease resistant mutants Here we report that PA is an efficient apoptosis agent triggering cell death of hypersensitive like response in planta Confirmed by Fluorescence Activated Cell Sorter FACS rice suspension cells and leaves exhibited programmed cell death induced by PA The PA induced cell death was associated with the accumulation of reactive oxygen species that could be blocked by diphenylene iodonium chloride indicating that the generation of reactive oxygen species was NADPH oxidase dependent We also demonstrated the induction of rice defense related genes and subsequent resistant enhancement by PA against the rice blast fungus

    Original URL path: http://www.cell-research.com/arts.asp?id=1277 (2016-02-14)
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  • Cell Research
    and Signal Transduction 300 Fenglin Road 200032 Shanghai China Correspondence Hong Wei XUE Tel 86 21 64042090 ext 4411 E mail hwxue sibs ac cn The phosphatidylinositol PI metabolic pathway is considered critical in plant responses to many environmental factors and previous studies have indicated the involvement of multiple PI related gene families during cellular responses Through a detailed analysis of the Arabidopsis thaliana genome 82 polypeptides were identified as being involved in PI signaling These could be grouped into different families including PI synthases PIS PI phosphate kinases PIPK phospholipases PL inositol polyphosphate phosphatases IPPase inositol polyphosphate kinases IPK PI transfer proteins and putative inositol polyphosphate receptors The presence of more than 10 isoforms of PIPK PLC PLD and IPPase suggested that these genes might be differentially expressed during plant cellular responses or growth and development Accordingly DNA chip technology was employed to study the expression patterns of various isoforms In total 79 mRNA clones were amplified and used for DNA chip generation Expression profile analysis was performed using samples that represented multiple tissues or cellular responses Tested samples included normal leaf stem and flower tissues and leaves from plants treated with various hormones auxin cytokinin gibberellin abscisic acid

    Original URL path: http://www.cell-research.com/arts.asp?id=1278 (2016-02-14)
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  • Cell Research
    Academy of Medical Sciences Peking University of Medical School Beijing 100021 China 2 Department of Thoracic Surgery Cancer Institute Hospital Chinese Academy of Medical Sciences Peking University of Medical School Beijing 100021 China Correspondence Ming Rong WANG Tel 86 10 67781331 8425 E mail wangmr 263 net cn Migration inhibitory factor related protein 14 MRP14 is one of calcium binding proteins referred as S100A9 The heterodimeric molecule formed by MRP14 with its partner MRP8 S100A8 is the major fatty acid carrier in neutrophils The MRP8 14 complex has been also implicated in the intracellular transport of arachidonic acid and its precursors in keratinocytes We show here the involvement of MRP14 in human esophageal cancer In an initial study mRNA differential display reverse transcription polymerase chain reaction DD PCR was performed with two esophageal carcinomas one esophageal adenocarcinoma and matched normal adjacent mucosa DD PCR with the arbitrary primer OPA3 showed that one cDNA band was highly expressed in normal tissues but disappeared or substantially decreased in tumor counterparts It was later identified to be the 3 end of migration inhibitory factor related protein 14 MRP14 Northern blotting RT PCR and Western blotting corroborated the down regulation of MRP14 in 58

    Original URL path: http://www.cell-research.com/arts.asp?id=1279 (2016-02-14)
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