archive-com.com » COM » C » CELL-RESEARCH.COM

Total: 1754

Choose link from "Titles, links and description words view":

Or switch to "Titles and links view".
  • Cell Research
    Eric Xu1 3 1 VARI SIMM Center Center for Structure and Function of Drug Targets Key Laboratory of Receptor Research Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201203 China 2 The Institute of Biomedical Sciences and School of Life Sciences East China Normal University Shanghai 200241 China 3 Laboratory of Structural Sciences and Laboratory of Structural Biology and Biochemistry Van Andel Research Institute Grand Rapids Michigan USA 4 Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology Wuhan 430074 China 5 School of Chemistry and Biochemistry The University of Western Australia Crawley WA 6009 Australia 6 School of Biological Sciences University of Tasmania Hobart Hobart TAS 7001 Australia 7 State Key Laboratory of Plant Genomics and National Center for Plant Gene Research Beijing Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 China 8 Department of Molecular Therapeutics Translational Research Institute The Scripps Research Institute Scripps Florida Jupiter FL 33458 USA Correspondence Karsten Melcher E mail Karsten Melcher vai org H Eric Xu E mail Eric Xu vai org Strigolactones SLs are endogenous hormones and exuded signaling molecules in plant responses to low levels of mineral nutrients Key mediators of the SL signaling pathway in rice include the α β fold hydrolase DWARF 14 D14 and the F box component DWARF 3 D3 of the ubiquitin ligase SCFD3 that mediate ligand dependent degradation of downstream signaling repressors One perplexing feature is that D14 not only functions as the SL receptor but is also an active enzyme that slowly hydrolyzes diverse natural and synthetic SLs including GR24 preventing the crystallization of a binary complex of D14 with an intact SL as well as the ternary D14 SL D3 complex Here we overcome these barriers to derive a

    Original URL path: http://www.cell-research.com/arts.asp?id=2177 (2016-02-14)
    Open archived version from archive


  • Cell Research
    Metabolic engineering Institute of Microbiology Chinese Academy of Sciences Beijing 100101 China 4 Departments of Microbiology and Pediatrics University of Iowa Iowa City IA 52242 USA 5 State Key Laboratory of Biotherapy and Cancer Center West China Hospital West China Medical School Sichuan University Chengdu Sichuan 610041 China 6 Laboratory Animal Center Chinese Center for Disease Control and Prevention China CDC Beijing 102206 China 7 State Key Laboratory for Emerging Infectious Diseases Department of Microbiology The University of Hong Kong Pokfulam Hong Kong SAR 60518120 China 8 National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention China CDC Beijing 102206 China 9 China Japan Joint Laboratory of Molecular Microbiology and Molecular Immunology Institute of Microbiology Chinese Academy of Sciences Beijing 100101 China 10 Office of Director General Chinese Center for Disease Control and Prevention China CDC Beijing 102206 China 11 State Key Laboratory of Respiratory Diseases Guangzhou Institute of Respiratory Disease The First Affiliated Hospital of Guangzhou Medical University Guangzhou Guangdong 510120 China Correspondence Jinghua Yan E mail yanjh im ac cn George F Gao E mail gaof im ac cn The newly emerging Middle East respiratory syndrome coronavirus MERS CoV can cause severe and fatal acute respiratory disease in humans Despite global efforts the potential for an associated pandemic in the future cannot be excluded The development of effective counter measures is urgent MERS CoV specific anti viral drugs or vaccines are not yet available Using the spike receptor binding domain of MERS CoV MERS RBD to immunize mice we identified two neutralizing monoclonal antibodies mAbs 4C2 and 2E6 Both mAbs potently bind to MERS RBD and block virus entry in vitro with high efficacy We further investigated their mechanisms of neutralization by crystallizing the complex between the Fab fragments and the RBD

    Original URL path: http://www.cell-research.com/arts.asp?id=2178 (2016-02-14)
    Open archived version from archive

  • Cell Research
    Imaging Center BIOPIC College of Life Sciences Peking University Beijing 100871 China 2 Department of Surgery Beijing Shijitan Hospital Capital Medical University Beijing 100038 China 3 Department of Hepatobiliary Surgery Peking University People s Hospital Beijing 100044 China 4 Ninth School of Clinical Medicine Peking University Beijing 100044 China 5 School of Oncology Capital Medical University Beijing 100069 China 6 Center of Therapeutic Research for Liver Cancer Beijing 302 Hospital Beijing 100039 China 7 Department of Hepatobiliary Surgery Beijing DiTan Hospital Capital Medical University Beijing 100015 China 8 Ministry of Education Key Laboratory of Cell Proliferation and Differentiation College of Life Sciences Peking University Beijing 100871 China 9 BIMCR Peking University Beijing 100871 China 10 Peking Tsinghua Center for Life Sciences Peking University Beijing 100871 China 11 College of Engineering Peking University Beijing 100871 China Correspondence Fuchou Tang E mail tangfuchou pku edu cn Yanyi Huang E mail yanyi pku edu cn Jirun Peng E mail pengjr medmail com cn Despite advances in DNA methylome analyses of cells and tissues current techniques for genome scale profiling of DNA methylation in circulating cell free DNA ccfDNA remain limited Here we describe a methylated CpG tandems amplification and sequencing MCTA Seq method that can detect thousands of hypermethylated CpG islands simultaneously in ccfDNA This highly sensitive technique can work with genomic DNA as little as 7 5 pg which is equivalent to 2 5 copies of the haploid genome We have analyzed a cohort of tissue and plasma samples n 151 of hepatocellular carcinoma HCC patients and control subjects identifying dozens of high performance markers in blood for detecting small HCC 3 cm Among these markers 4 RGS10 ST8SIA6 RUNX2 and VIM are mostly specific for cancer detection while the other 15 classified as a novel set are already hypermethylated in the

    Original URL path: http://www.cell-research.com/arts.asp?id=2179 (2016-02-14)
    Open archived version from archive

  • Cell Research
    Bioscience and Bioengineering South China University of Technology Guangzhou Guangdong 510006 Institute of Life Sciences Municipal Key Laboratory of Geriatric Chinese PLA General Hospital the State Key Laboratory of Kidney Beijing 100853 China 2 Institute of Biotechnology 20 Dongdajie Beijing 100071 China 3 302 Military Hospital of China Beijing 100039 China 4 The First Affiliated Hospital Sun Yat Sen University Guangzhou Guangdong 510080 China 5 Beijing Institute of Microbiology and Epidemiology Beijing 100071 China 6 Beijing Institute of Genomics Chinese Academy of Sciences Beijing 100101 China Correspondence Qiang Sun E mail sunqiang bmi ac cn Xiaoning Wang E mail xnwang88 163 com Chronic virus infection such as infection by Epstein Barr virus EBV hepatitis B C virus HBV HCV and human immunodeficiency virus HIV constitutes major public health concerns Although efforts in deciphering the mechanisms underlying their virological consequences have greatly improved clinical prevention and therapy various challenges such as virus tropism drifting remain to be addressed to develop effective clinical interventions While cell free viruses usually infect target cells via binding to specific receptors the presence of virions in non susceptible cells has been reported with the mechanisms poorly understood1 Recently we reported that EBV could infect non susceptible

    Original URL path: http://www.cell-research.com/arts.asp?id=2180 (2016-02-14)
    Open archived version from archive

  • Cell Research
    drug cocktail OPEN Lin Cheng 1 4 Longfei Gao 1 Wuqiang Guan 2 Jianxin Mao 1 Wenxiang Hu 1 Binlong Qiu 1 Jian Zhao 1 Yongchun Yu 2 and Gang Pei 1 3 1 State Key Laboratory of Cell Biology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China 2 State Key Laboratory of Medical Neurobiology Shanghai Medical College and Institutes of Brain Science Fudan University Shanghai 200032 China 3 Collaborative Innovation Center for Brain Science School of Life Science and Technology Tongji University Shanghai 200092 China 4 State Key Laboratory of Medical Genomics Shanghai Institute of Hematology Rui Jin Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200025 China Correspondence Gang Pei E mail gpei sibs ac cn Neurological disorder is one of the greatest threats to public health according to the World Health Organization Because neurons have little or no regenerative capacity conventional therapies for neurological disorders yielded poor outcomes While the introduction of exogenous neural stem cells or neurons holds promise many challenges still need to be tackled including cell resource delivery strategy cell integration and cell maturation Reprogramming of fibroblasts into induced pluripotent stem cells or

    Original URL path: http://www.cell-research.com/arts.asp?id=2181 (2016-02-14)
    Open archived version from archive

  • Cell Research
    Online Publication Current Issue Top 10 VOLUME 25 ISSUE 11 11 2015 1273 1276 Loss of the sulfate transporter Slc13a4 in placenta causes severe fetal abnormalities and death in mice FREE Joanna Rakoczy Zhe Zhang Francis Gerard Bowling Paul Anthony Dawson and David Gordon Simmons Sulfate is an obligate nutrient for numerous cellular and metabolic processes important for fetal development1 Fetal tissues express sulfotransferases which conjugate sulfate sulfonate to molecules

    Original URL path: http://www.cell-research.com/arts.asp?id=2183 (2016-02-14)
    Open archived version from archive

  • Cell Research

    (No additional info available in detailed archive for this subpage)
    Original URL path: /artsmore1.asp?id=189 (2016-02-14)


  • Cell Research
    J Klionsky 2 1 Comparative Biomedicine Research Branch Division of Cancer Biology National Cancer Center 323 Ilsan ro Ilsandong gu Goyang Gyeonggi do 410 769 Republic of Korea 2 University of Michigan Life Sciences Institute Ann Arbor MI 481098 2216 USA Correspondence Heesun Cheong E mail heesunch ncc re kr Daniel J Klionsky E mail klionsky umich edu Anticancer therapeutics aimed at the inhibition of mTORC1 activity shift metabolism to

    Original URL path: http://www.cell-research.com/arts.asp?id=2159 (2016-02-14)
    Open archived version from archive



  •