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  • Cell Research

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    Original URL path: /artsmore1.asp?id=103 (2016-02-14)



  • Cell Research
    Tel 301 846 1589 E mail shou mail ncifcrf gov In multicellular organisms biological activities are regulated by cell signaling The various signal transduction pathways regulate cell fate proliferation migration and polarity Miscoordination of the communicative signals will lead to disasters like cancer and other fatal diseases The JAK STAT signal transduction pathway is one of the pathways which was first identified in vertebrates and is highly conserved throughout evolution

    Original URL path: http://www.cell-research.com/arts.asp?id=1212 (2016-02-14)
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  • Cell Research
    VOLUME 11 ISSUE 1 1 2005 6 10 WNK1 analysis of protein kinase structure downstream targets and potential roles in hypertension Bing e XU 1 Byung Hoon LEE 1 Xiaoshan MIN 2 Lisa LENERTZ 1 Charles J HEISE 1 Steve STIPPEC 1 Elizabeth J GOLDSMITH 2 Melanie H COBB 1 1 Department of Pharmacology University of Texas Southwestern Medical Center 5323 Harry Hines Blvd Dallas USA 2 Department of Biochemistry University of Texas Southwestern Medical Center 5323 Harry Hines Blvd Dallas USA Correspondence Melanie H COBB Tel 214 648 3627 E mail melanie cobb UTSouthwestern edu The WNK kinases are a recently discovered family of serine threonine kinases that have been shown to play an essential role in the regulation of electrolyte homeostasis Intronic deletions in the WNK1 gene result in its overexpression and lead to pseudohypoaldosteronism type II a disease with salt sensitive hypertension and hyperkalemia This review focuses on the recent evidence elucidating the structure of the kinase domain of WNK1 and functions of these kinases in normal and disease physiology Their functions have implications for understanding the biochemical mechanism that could lead to the retention or insertion of proteins in the plasma membrane The WNK kinases may

    Original URL path: http://www.cell-research.com/arts.asp?id=1213 (2016-02-14)
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  • Cell Research
    members of the mitogen activated protein MAP kinases mediate a wide variety of cellular behaviors in response to extracellular stimuli One of the four main sub groups the p38 group of MAP kinases serve as a nexus for signal transduction and play a vital role in numerous biological processes In this review we highlight the known characteristics and components of the p38 pathway along with the mechanism and consequences of

    Original URL path: http://www.cell-research.com/arts.asp?id=1216 (2016-02-14)
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  • Cell Research
    rosner uchicago edu Proteins like Raf kinase inhibitory protein RKIP that serve as modulators of signaling pathways either by promoting or inhibiting the formation of productive signaling complexes through protein protein interactions have been demonstrated to play an increasingly important role in a number of cell types and organisms These proteins have been implicated in development as well as the progression of cancer RKIP is a particularly interesting regulator as

    Original URL path: http://www.cell-research.com/arts.asp?id=1214 (2016-02-14)
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  • Cell Research
    Advanced Online Publication Current Issue Top 10 VOLUME 11 ISSUE 1 1 2005 24 27 Molecular mechanism of TNF signaling and beyond Zheng gang LIU Cell and Cancer Biology Branch Center for Cancer Research National Cancer Institute NIH 9000 Rockville Pike Bethesda MD 20892 USA Correspondence Zheng gang LIU E mail zgliu helix nih gov Tumor necrosis factor TNF is a proinflammatory cytokine that plays a critical role in diverse cellular events including cell proliferation differentiation and apoptosis TNF is also involved in many types of diseases In recent years the molecular mechanisms of TNF functions have been intensively investigated Studies from many laboratories have demonstrated that the TNF mediated diverse biological responses are achieved through activating multiple signaling pathways Especially the activation of transcription factors NF κB and AP 1 plays a critical role in mediating these cellular responses Several proteins including FADD the death domain kinase RIP and the TNF receptor associated factor TRAF2 have been identified as the key effectors of TNF signaling Recently we found that the effector molecules of TNF signaling such as RIP and TRAF2 are also involved in other cellular responses These finding suggests that RIP and TRAF2 serve a broader role than

    Original URL path: http://www.cell-research.com/arts.asp?id=1215 (2016-02-14)
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  • Cell Research
    Abl in the DNA damage stress response Yosef SHAUL Merav BEN YEHOYADA Department of Molecular Genetics Weizmann Institute of Scienc Rehovot 76100 Israel Correspondence Yosef SHAUL Tel 972 8 934 2320 E mail yosef shaul weizmann ac il c Abl has been implicated in many cellular processes including differentiation division adhesion death and stress response c Abl is a latent tyrosine kinase that becomes activated in response to numerous extra

    Original URL path: http://www.cell-research.com/arts.asp?id=1218 (2016-02-14)
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  • Cell Research
    5841 S Maryland Avenue MC 6027 Chicago IL 60637 USA Correspondence Anning LIN Tel 773 753 1408 E mail alin huggins bsd uchicago edu JNK is a key regulator of many cellular events including programmed cell death apoptosis In the absence of NF κB activation prolonged JNK activation contributes to TNF α induced apoptosis JNK is also essential for UV induced apoptosis However recent studies reveal that JNK can suppress

    Original URL path: http://www.cell-research.com/arts.asp?id=1219 (2016-02-14)
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