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  • Cell Research
    100850 China Correspondence Qing Jun MA Tel 86 10 66931813 E mail maqj vip sina com Endostatin is a natural occurred angiogenesis inhibitor derived from collagenXVIII So far its function during the angiogenesis process of bone formation and arthropathy has not been well studied yet The present study addresses the function of endostatin in rabbit articular chondrocytes RAC We found that endostatin can promote RAC adhesion and spreading as well

    Original URL path: http://www.cell-research.com/arts.asp?id=1200 (2016-02-14)
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  • Cell Research
    Issue Submission Advanced Online Publication Current Issue Top 10 VOLUME 15 ISSUE 3 3 2005 207 211 Identification of connexin 50 and 57 mRNA in A type horizontal cells of the rabbit retina He HUANG Hui LI Shi Gang HE Institute of Neuroscience Shanghai Institutes for Biological Sciences Chinese Academy of Sciences 320 Yueyang Road Shanghai 200031 China Correspondence He HUANG Tel 86 21 5492 1771 E mail huanghe sibs ac cn Horizontal cells HCs mediate negative feedback to photoreceptors In the mammalian retina there are two types of HCs which are extensively coupled to neighboring cells through homologous gap junctions The permeability and therefore the strength of feedback can be regulated by light intensity dopamine and many other factors However the component s of the most prominent gap junctions those between A type HCs in the rabbit retina is still unknown In this study we compared the sequences of many types of mammalian connexins obtained partial sequences of rabbit connexin 50 and 57 Using specific primers designed against the rabbit sequences we identified mRNAs of connexin 50 and or 57 in visually selected single A type HC using multiplex RT PCR keywords gap junctions dissociated retinal neurons single cell

    Original URL path: http://www.cell-research.com/arts.asp?id=1201 (2016-02-14)
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  • Cell Research
    QIN 1 Xiao CHEN 1 Jing De ZHU 2 Duan Qing PEI 1 1 Guangzhou Institute of Biomedicine and Health GIBH Chinese Academy of Sciences Guangzhou 510663 China 2 The State key Laboratory for Oncogenes and Related Genes Shanghai Cancer Institute Shanghai Jiatong University LN2200 25 Xietu Road Shanghai 200032 China Correspondence Duan Qing PEI E mail pei duanqing gibh ac cn Lung cancer is one of the leading causes of death with one of the lowest survival rates However a subset of lung cancer patients who are of Asian origin and carry somatic mutations in epidermal growth factor receptor or EGFR have responded remarkable well to two tyrosine kinase inhibitors gefitinib and erlotinib While EGFR mutation profiles have been reported from Japan South Korea and Taiwan there is no such report from mainland of China where the largest pool of patients reside In this report we identified ten somatic mutations from a total of 41 lung cancer patients in China Among them seven mutations were found in 17 adenocarcinomas In contrast to previous reports eight of these mutations are deletions in exon 19 and two of these deletions are homozygous These results suggest that a large portion of Chinese

    Original URL path: http://www.cell-research.com/arts.asp?id=1202 (2016-02-14)
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  • Cell Research

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    Original URL path: /artsmore1.asp?id=100 (2016-02-14)


  • Cell Research
    Issue Top 10 VOLUME 15 ISSUE 4 4 2005 228 236 14 3 3 proteins an update Paulette Mhawech Department of Pathology and Laboratory Medicine at Roswell Park Cancer Institute Elm and Carlton Streets Buffalo New York14263 USA Correspondence Paulette Mhawech Tel 01 716 845 3204 E mail pmhawech1 yahoo com 14 3 3 is a highly conserved acidic protein family composed of seven isoforms in mammals 14 3 3 protein can interact with over 200 target proteins by phosphoserine dependent and phosphoserine independent manners Little is known about the consequences of these interactions and thus are the subjects of ongoing studies 14 3 3 controls cell cycle cell growth differentiation survival apoptosis migration and spreading Recent studies have revealed new mechanisms and new functions of 14 3 3 giving us more insights on this fascinating and complex family of proteins Of all the seven isoforms 14 3 3δ seems to be directly involved in human cancer 14 3 3δ itself is subject to regulation by p53 upon DNA damage and by epigenetic deregulation Gene silencing of 14 3 3δ by CpG methylation has been found in many human cancer types This suggests that therapy targeting 14 3 3δ may

    Original URL path: http://www.cell-research.com/arts.asp?id=1184 (2016-02-14)
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  • Cell Research
    mpg de Cancer cells show characteristic alterations in DNA methylation patterns Aberrant CpG methylation of specific promoters results in inactivation of tumor suppressor genes and therefore plays an important role in carcinogenesis The p53 regulated gene 14 3 3δ undergoes frequent epigenetic silencing in several types of cancer including carcinoma of the breast prostate and skin suggesting that the loss of 14 3 3δ expression may be causally involved in

    Original URL path: http://www.cell-research.com/arts.asp?id=1185 (2016-02-14)
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  • Cell Research
    Center Houston Texas USA Correspondence Tsung Teh WU Tel 713 745 4977 E mail twu mdanderson org Gastric cancer is believed to result in part from the accumulation of multiple genetic alterations leading to oncogene overexpression and tumor suppressor loss Epigenetic alterations as a distinct and crucial mechanism to silence a variety of methylated tissue specific and imprinted genes have been extensively studied in gastric carcinoma and play important roles

    Original URL path: http://www.cell-research.com/arts.asp?id=1186 (2016-02-14)
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  • Cell Research
    virus associated human cancers Hsin Pai LI 1 Yu Wei LEU 2 Yu Sun CHANG 1 1 Graduate Institute of Basic Medical Sciences Chang Gung University Kwei shan Taoyuan Taiwan 333 2 Department of Life Science and Institute of Molecular Biology ChungCheng University Ming Hsiung Chia Yi Taiwan 621 Correspondence Yu Sun CHANG Tel 886 3 211 8800 ext 5131 E mail ysc mail cgu edu tw Epigenetics of human cancer becomes an area of emerging research direction due to a growing understanding of specific epigenetic pathways and rapid development of detection technologies Aberrant promoter hypermethylation is a prevalent phenonmena in human cancers Tumor suppressor genes are often hypermethylated due to the increased activity or deregulation of DNMTs Increasing evidence also reveals that viral genes are one of the key players in regulating DNA methylation In this review we will focus on hypermethylation and tumor suppressor gene silencing and the signal pathways that are involved particularly in cancers closely associated with the hepatitis B virus simian virus 40 SV40 and Epstein Barr virus In addition we will discuss current technologies for genome wide detection of epigenetically regulated targets which allow for systematic DNA hypermethylation analysis The study of epigenetic changes

    Original URL path: http://www.cell-research.com/arts.asp?id=1188 (2016-02-14)
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