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  • Cell Research
    Issue Top 10 VOLUME 15 ISSUE 4 4 2005 272 280 The altered DNA methylation pattern and its implications in liver cancer Jing De ZHU 1 2 1 The State key Laboratory for Oncogenes and Related Genes Shanghai Cancer Institute Shanghai Jiaotong University LN 2200 25 Xietu Road Shanghai 200032 China 2 The Collage of Life Sciences Zhejiang Science and Technology University Xiasha University District Hangzhou Zhejiang 310018 China Correspondence Jing De ZHU Tel 86 21 64224285 E mail zhujingde yahoo com or zhujingde sh163 net DNA methylation is the most intensively studied epigenetic phenomenon disturbances of which result in changes in gene transcription thus exerting drastic imparts onto biological behaviors of cancer Both the global demethylation and the local hypermethylation have been widely reported in all types of tumors providing both challenges and opportunities for a better understanding and eventually controlling of the malignance However we are still in the very early stage of information accumulation concerning the tumor associated changes in DNA methylation pattern A number of excellent recent reviews have covered this issue in depth Therefore this review will summarize our recent data on DNA methylation profiling in cancers Perspectives for the future direction in this dynamic

    Original URL path: http://www.cell-research.com/arts.asp?id=1189 (2016-02-14)
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  • Cell Research
    Publication Current Issue Top 10 VOLUME 15 ISSUE 4 4 2005 281 291 Tudor and its domains germ cell formation from a Tudor perspective Travis Thomson Paul Lasko Department of Biology McGill University Montreal Quebec Canada H3A 1B1 Correspondence Paul Lasko Tel 1 514 398 6401 E mail paul lasko mcgill ca In many metazoan species germ cell formation requires the germ plasm a specialized cytoplasm which often contains electron dense structures Genes required for germ cell formation in Drosophila have been isolated predominantly in screens for maternal effect mutations One such gene is tudor tud without proper tud function germ cell formation does not occur Unlike other genes involved in Drosophila germ cell specification tud is dispensable for other somatic functions such as abdominal patterning It is not known how TUD contributes at a molecular level to germ cell formation but in tud mutants polar granule formation is severely compromised and mitochondrially encoded ribosomal RNAs do not localize to the polar granule TUD is composed of 11 repeats of the protein motif called the Tudor domain There are similar proteins to TUD in the germ line of other metazoan species including mice Probable vertebrate orthologues of Drosophila genes involved

    Original URL path: http://www.cell-research.com/arts.asp?id=1190 (2016-02-14)
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  • Cell Research
    Publication Current Issue Top 10 VOLUME 15 ISSUE 4 4 2005 292 300 Chromatin domain boundaries insulators and beyond Gong Hong Wei De Pei Liu Chih Chuan Liang National Laboratory of Medical Molecular Biology Institute of Basic Medical Sciences Chinese Academy of Medical Sciences and Peking Union Medical College 5 Dong Dan San Tiao Beijing 100005 China Correspondence De Pei Liu Tel 86 10 65296415 E mail liudp pumc edu cn The eukaryotic genome is organized into functionally and structurally distinct domains representing regulatory units for gene expression and chromosome behavior DNA sequences that mark the border between adjacent domains are the insulators or boundary elements which are required in maintenance of the function of different domains Some insulators need others enable to play insulation activity Chromatin domains are defined by distinct sets of post translationally modified histones Recent studies show that these histone modifications are also involved in establishment of sharp chromatin boundaries in order to prevent the spreading of distinct domains Additionally in some loci the high order chromatin structures for long range looping interactions also have boundary activities suggesting a correlation between insulators and chromatin loop domains In this review we will discuss recent progress in the

    Original URL path: http://www.cell-research.com/arts.asp?id=1191 (2016-02-14)
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  • Cell Research

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    Original URL path: /artsmore1.asp?id=99 (2016-02-14)


  • Cell Research
    tooth growth factors transcription factors and stem cells Yan Ding ZHANG 1 2 Zhi CHEN 1 Yi Qiang SONG 3 Chao LIU 2 Yi Ping CHEN 2 3 1 College of Stomatology Wuhan University Wuhan 430072 China 2 College of Bioengineering Fujian Normal University Fuzhou 350007 China 3 Division of Developmental Biology Department of Cell and Molecular Biology Tulane University New Orleans LA 70118 USA Correspondence Yi Ping CHEN Tel 504 865 5587 E mail ychen tulane edu Mammalian tooth development is largely dependent on sequential and reciprocal epithelial mesenchymal interactions These processes involve a series of inductive and permissive interactions that result in the determination differentiation and organization of odontogenic tissues Multiple signaling molecules including BMPs FGFs Shh and Wnt proteins have been implicated in mediating these tissue interactions Transcription factors participate in epithelial mesenchymal interactions via linking the signaling loops between tissue layers by responding to inductive signals and regulating the expression of other signaling molecules Adult stem cells are highly plastic and multipotent These cells including dental pulp stem cells and bone marrow stromal cells could be reprogrammed into odontogenic fate and participated in tooth formation Recent progress in the studies of molecular basis of tooth development

    Original URL path: http://www.cell-research.com/arts.asp?id=1173 (2016-02-14)
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  • Cell Research
    Department of Internal Medicine I Division of Hematology and Hemostaseology Vienna Austria 3 University of Tübingen Proteome Center Tübingen Germany 4 University Clinic of Tübingen Department of Dermatology Tübingen Germany Correspondence Hans Jörg BÜHRING Tel 49 7071 2982730 E mail hans joerg buehring uni tuebingen de Using two colour flow cytometry 200 antibodies submitted to the 8th International Workshop of Human Leukocyte Differentiation Antigens HLDA8 have been analyzed for their reactivity with resting and activated CD203c basophils Four antibodies either non reactive or weakly reactive with resting basophils exhibited an increased reactivity with basophils activated by anti IgE mediated cross linking of the high affinity IgE receptor FcεRI These include antibodies against CD164 WS 80160 clone N6B6 and WS 80162 clone 67D2 as well as two reagents with previously unknown specificities that were identified as CD13 WS 80274 clone A8 and CD107a WS 80280 clone E63 880 The activation patterns followed either the CD203c like or CD63 like activation profile The CD203c profile is characterized by a rapid and significant upregulation of CD13 CD164 and CD203c reaching maximum levels after 5 15 min of stimulation The phosphoinositide 3 kinase PI3K specific inhibitor wortmannin inhibited the upregulation of these markers whereas

    Original URL path: http://www.cell-research.com/arts.asp?id=1175 (2016-02-14)
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  • Cell Research
    and Technology Xinxiang 453003 China Correspondence Bao Hong ZHANG Tel 1 806 8854567 E mail baohong zhang ttu edu Seventy five previously known plant microRNAs miRNAs were classified into 14 families according to their gene sequence identity A total of 18 694 plant expressed sequence tags EST were found in the GenBank EST databases by comparing all previously known Arabidopsis miRNAs to GenBank s plant EST databases with BLAST algorithms After removing the EST sequences with high numbers more than 2 of mismatched nucleotides a total of 812 EST contigs were identified After predicting and scoring the RNA secondary structure of the 812 EST sequences using mFold software 338 new potential miRNAs were identified in 60 plant species miRNAs are widespread Some microRNAs may highly conserve in the plant kingdom and they may have the same ancestor in very early evolution There is no nucleotide substitution in most miRNAs among many plant species Some of the new identified potential miRNAs may be induced and regulated by environmental biotic and abiotic stresses Some may be preferentially expressed in specific tissues and are regulated by developmental switching These findings suggest that EST analysis is a good alternative strategy for identifying new miRNA

    Original URL path: http://www.cell-research.com/arts.asp?id=1176 (2016-02-14)
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  • Cell Research
    Yan JIN Yong WEI Lei XIONG Ying YANG Jia Rui WU Laboratory of Molecular Cell Biology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences 320 Yue Yang Road Shanghai 200031 China Correspondence Jia Rui WU Tel 86 21 54921128 E mail wujr sibs ac cn Recent studies indicate that cell cycle checkpoints are tightly correlated with the regulation of apoptosis in which p53 plays an important role Our present works show that the expression of E6 E7 oncogenes of human papillomavirus in HeLa cells is inhibited in the presence of anti tumor reagent tripchlorolide TC which results in the up regulation of p53 in HeLa cells Interestingly under the same TC treatment the cells at the early S phase are more susceptible to apoptosis than those at the middle S phase although p53 protein is stabilized to the same level in both situations Significant difference is exhibited between the two specified expression profiles Further analysis demonstrates that anti apoptotic gene survivin is up regulated by p53 in the TC treated middle S cells whereas it is down regulated by p53 in the TC treated early S cells Taken together the present study indicates

    Original URL path: http://www.cell-research.com/arts.asp?id=1177 (2016-02-14)
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