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  • Cell Research
    Current Issue Top 10 VOLUME 25 ISSUE 10 10 2015 1087 1088 How phosphoubiquitin activates Parkin E3 activity FREE Xinde Zheng1 and Tony Hunter 1 1 Molecular and Cell Biology Laboratory Salk Institute for Biological Studies 10010 North Torrey Pines Road La Jolla CA 92037 USA Correspondence Tony Hunter Tel 1 858 453 4100 ext 1385 E mail hunter salk edu A recent report solving the structure of a Parkin

    Original URL path: http://www.cell-research.com/arts.asp?id=2160 (2016-02-14)
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  • Cell Research
    10 2015 1089 1090 RNA Pol II as a sensor of 5caC FREE Jian Huang Xue 1 and Guo Liang Xu 1 1 Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China Correspondence Guo Liang Xu E mail glxu sibs ac cn Cytosines in genomic DNA come in different flavors A recent paper published in Nature reveals that an oxidized variety

    Original URL path: http://www.cell-research.com/arts.asp?id=2161 (2016-02-14)
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  • Cell Research
    VOLUME 25 ISSUE 10 10 2015 1091 1092 Cutting in on a secretase pas de deux FREE Michael S Wolfe 1 1 Ann Romney Center for Neurologic Diseases Brigham and Women s Hospital Harvard Medical School Boston MA 02115 USA Two proteolytic enzymes β and γ secretases work together to produce the amyloid β peptide of Alzheimer s disease New evidence suggests that these proteases directly interact and compounds that

    Original URL path: http://www.cell-research.com/arts.asp?id=2162 (2016-02-14)
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  • Cell Research
    Wang 1 Chunxia Zhang 1 Dongyuan Ma 1 Wei Li 3 Bing Liu 2 and Feng Liu 1 1 State Key Laboratory of Membrane Biology Institute of Zoology Chinese Academy of Sciences Beijing 100101 China 2 307 Ivy Translational Medicine Center Laboratory of Oncology Affiliated Hospital of Academy of Military Medical Sciences Beijing 100071 China 3 State Key Laboratory of Reproductive Biology Institute of Zoology Chinese Academy of Sciences Beijing 100101 China Correspondence Feng Liu Tel 86 10 64807307 Fax 86 10 64807313 E mail liuf ioz ac cn In vertebrates embryonic hematopoietic stem and progenitor cells HSPCs are derived from a subset of endothelial cells the hemogenic endothelium HE through the endothelial to hematopoietic transition EHT Notch signaling is essential for HSPC development during embryogenesis across vertebrates However whether and how it regulates EHT remains unclear Here we show that G protein coupled receptor 183 Gpr183 signaling serves as an indispensable switch for HSPC emergence by repressing Notch signaling before the onset of EHT Inhibition of Gpr183 significantly upregulates Notch signaling and abolishes HSPC emergence Upon activation by its ligand 7α 25 OHC Gpr183 recruits β arrestin1 and the E3 ligase Nedd4 to degrade Notch1 in specified HE cells

    Original URL path: http://www.cell-research.com/arts.asp?id=2163 (2016-02-14)
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  • Cell Research
    Yujie Sun 2 3 and Li Yu 1 4 1 State Key Laboratory of Biomembrane and Membrane Biotechnology Tsinghua University Peking University Joint Center for Life Sciences School of Life Sciences Tsinghua University Beijing 100084 China 2 State Key Laboratory of Membrane Biology Biodynamic Optical Imaging Center BIOPIC Beijing 100871 China 3 School of Life Sciences Peking University Beijing 100871 China 4 School of Life Sciences Tsinghua University Beijing 100084 China 5 Mathematical Science Center Tsinghua University Beijing 100084 China Correspondence Li Yu E mail liyulab mail tsinghua edu cn Yujie Sun E mail sun yujie pku edu cn Mitochondria form networks Formation of mitochondrial networks is important for maintaining mitochondrial DNA integrity and interchanging mitochondrial material whereas disruption of the mitochondrial network affects mitochondrial functions According to the current view mitochondrial networks are formed by fusion of individual mitochondria Here we report a new mechanism for formation of mitochondrial networks through KIF5B mediated dynamic tubulation of mitochondria We found that KIF5B pulls thin highly dynamic tubules out of mitochondria Fusion of these dynamic tubules which is mediated by mitofusins gives rise to the mitochondrial network We further demonstrated that dynamic tubulation and fusion is sufficient for mitochondrial network formation

    Original URL path: http://www.cell-research.com/arts.asp?id=2164 (2016-02-14)
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  • Cell Research
    Bing Xie 1 and Xuetao Cao 1 2 3 1 Institute of Immunology Zhejiang University School of Medicine Hangzhou Zhejiang 310058 China 2 National Key Laboratory of Medical Immunology Institute of Immunology Second Military Medical University Shanghai 200433 China 3 National Key Laboratory of Medical Molecular Biology Department of Immunology Institute of Basic Medical Sciences Chinese Academy of Medical Sciences Beijing 100005 China Correspondence Xuetao Cao Tel 86 571 8820 8283 Fax 86 571 8820 8022 E mail caoxt immunol org Type I interferon IFN production plays pivotal roles in host antiviral innate immune responses but an excessive production of type I IFN leads to the development of immunopathological conditions Investigations on the regulatory mechanisms underlying host type I IFN production are currently of great interest Here we found that the expression of lectin family member Siglec1 was upregulated by viral infection in macrophages which was dependent on the IFN JAK STAT1 signaling pathway Siglec1 was found to negatively regulate viral infection triggered type I IFN production Mechanistically Siglec1 associates with DAP12 to recruit and activate the scaffolding function of SHP2 SHP2 then recruits E3 ubiquitin ligase TRIM27 which induces TBK1 degradation via K48 linked ubiquitination at Lys251 and Lys372

    Original URL path: http://www.cell-research.com/arts.asp?id=2165 (2016-02-14)
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  • Cell Research
    1 1 State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Disease Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China Correspondence Shengshou Hu Tel 86 10 88396011 Fax 86 10 88398359 E mail shengshouhu yahoo com Yu Nie Tel 86 10 60866139 Fax 86 10 60866092 E mail nieyuniverse 126 com Cardiac injury in neonatal 1 day old mice stimulates a regenerative response characterized by reactive cardiomyocyte proliferation which is distinguished from the fibrotic repair process in adults Acute inflammation occurs immediately after heart injury and has generally been believed to exert a negative effect on heart regeneration by promoting scar formation in adults however little is known about the role of acute inflammation in the cardiac regenerative response in neonatal mice Here we show that acute inflammation induced cardiomyocyte proliferation after apical intramyocardial microinjection of immunogenic zymosan A particles into the neonatal mouse heart We also found that cardiac injury induced regenerative response was suspended after immunosuppression in neonatal mice and that cardiomyocytes could not be reactivated to proliferate after neonatal heart injury in the absence of interleukin 6 IL 6 Furthermore cardiomyocyte specific deletion of signal transducer and activator of

    Original URL path: http://www.cell-research.com/arts.asp?id=2166 (2016-02-14)
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  • Cell Research
    1 Shoujun Huang 1 Guoqiang Zhang 1 Xiaohui Liu 2 Yi Tao 3 Shian Wu 2 and Dahua Chen 1 1 State Key Laboratory of Reproductive Biology Institute of Zoology Chinese Academy of Sciences Datun Road Chaoyang Beijing 100101 China 2 State Key Laboratory of Medicinal Chemical Biology and College of Life Sciences Nankai University Tianjin 300071 China 3 Centre for Computational and Evolutionary Biology Institute of Zoology Chinese Academy of Sciences Beijing 100101 China Correspondence Dahua Chen E mail chendh ioz ac cn Shian Wu E mail wusa nankai edu cn Many stem cell populations are tightly regulated by their local microenvironment niche which comprises distinct types of stromal cells However little is known about mechanisms by which niche subgroups coordinately determine the stem cell fate Here we identify that Yki the key Hippo pathway component is essential for escort cell EC function in promoting germline differentiation in Drosophila ovary We found that Hedgehog Hh signals emanating primarily from cap cells support the function of ECs where Cubitus interruptus Ci the Hh signaling effector acts to inhibit Hippo kinase cascade activity Mechanistically we found that Ci competitively interacts with Hpo and impairs the Hpo Wts signaling complex formation thereby

    Original URL path: http://www.cell-research.com/arts.asp?id=2167 (2016-02-14)
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