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  • Cell Research

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    Original URL path: /artsmore1.asp?id=94 (2016-02-14)



  • Cell Research
    Department of Immunology Duke University Medical Center Durham NC 27710 USA Correspondence You Wen HE Tel 1 919 613 7870 E mail he000004 mc duke edu Apoptosis plays an essential role in T cell biology Thymocytes expressing nonfunctional or autoreactive TCRs are eliminated by apoptosis during development Apoptosis also leads to the deletion of expanded effector T cells during immune responses The dysregulation of apoptosis in the immune system results

    Original URL path: http://www.cell-research.com/arts.asp?id=1131 (2016-02-14)
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  • Cell Research
    776 Systemic delivery of full length C EBPb liposome complex suppresses growth of human colon cancer in nude mice Li SUN Bei Bei FU Ding Gan LIU State Key Laboratory of Molecular Biology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China Correspondence Ding Gan LIU Tel 86 21 54921135 E mail E mail dgliu sibs ac cn C EBPb CCAAT enhancer binding protein b is an important transcription factor involved in cellular proliferation and differentiation Overexpression of the full length C EBPb protein results in cellular growth arrest and apoptosis Using a nonviral liposome as carrier we delivered the full length C EBPb expression plasmid pCN into nude mice bearing CW 2 human colon cancer tumors via tail vein Southern blots revealed that the major organs and tumors were transfected Experimental gene therapy showed that a strong suppression of tumor growth was observed in the pCN treated mice and such suppression was due to the overexpression of C EBPb leading to the increased apoptosis in tumors of pCN treated mice No apparent toxic effects of pCN liposome complex were observed in the animals Thus C EBPb has tumor suppression effect

    Original URL path: http://www.cell-research.com/arts.asp?id=1132 (2016-02-14)
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  • Cell Research
    of Medicine Central South University 110 Xiangya Road Changsha Hunan 410078 China 2 Molecular Medical Center Tongji Hospital Tongji Medical University Wuhan 430030 China Received Sep 12 2005 Revised Sep 26 2005 Accepted Oct 15 2005 Correspondence Ya CAO Tel 86 731 4805448 E mail E mail ycao98 public cs hn cn Latent membrane protein 1 LMP1 an important protein encoded by Epstein Barr virus EBV has been implied to link with the pathogenesis of nasopharyngeal carcinoma NPC Its dual effects of increasing cell proliferation and inhibiting cell apoptosis have been confirmed In this study we showed that the expression of Survivin and CDK4 protein in CNE LMP1 a LMP1 positive NPC epithelial cell line is higher than in LMP1 negative NPC epithelial cell line CNE1 and the expression is LMP1 dosage dependent Although it was reported that Survivin specifically expressed in cell cycle G 2 M phase our studies suggested that LMP1 could promote the expression of Survivin in G 0 G 1 S and G 2 M phase It also showed that Survivin and CDK4 could be accumulated more in the nuclei triggered by LMP1 More interestingly Survivin and CDK4 could form a protein complex in the nuclei

    Original URL path: http://www.cell-research.com/arts.asp?id=1134 (2016-02-14)
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  • Cell Research
    PXR or Steroid and Xenobiotic Receptor SXR a new member of the nuclear receptor superfamily is thought to modulate a network of genes that are involved in xenobiotic metabolism and elimination To further explore the role of PXR in body s homeostatic mechanisms we for the first time report successful prokaryotic expression and purification of full length PXR and preparation of polyclonal antibody against the whole protein The full length cDNA encoding a 434 amino acids protein was sub cloned into prokaryotic expression vector pET 30b and transformed into E coli BL21 DE3 cells for efficient over expression The inclusion body fraction containing the expressed recombinant protein was purified first by solubilizing in sarcosine extraction buffer and then by affinity column chromatography using Ni NTA His Bind matrix The efficacy of anti PXR antibody was confirmed by immunocytology Western blot analysis EMSA and immunohistochemistry The antibody obtained was capable of detecting human and mouse PXR with high specificity and sensitivity Immunofluorescence staining of COS 1 cells transfected with human or mouse PXR showed a clear nuclear localization Results from immunohistochemistry showed that level of PXR in liver sections is immunologically detectable in the nuclei Similar to exogenously transfected PXR Western

    Original URL path: http://www.cell-research.com/arts.asp?id=1135 (2016-02-14)
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  • Cell Research
    Sciences Chinese Academy of Sciences 300 Fenglin Road Shanghai 200032 China 3 Graduate School of the Chinese Academy of Sciences D C 19 Yuquan Road Beijing 100039 China Correspondence Hong Xuan LIN Tel 86 21 54924129 E mail E mail hxlin sippe ac cn We used cDNA microarrays containing 9 000 unigenes to identify 486 salt responsive expressed sequence tags ESTs representing 450 unigenes in shoots of the highly salt tolerant rice variety Nona Bokra Oryza sativa L ssp Indica pv Nona Some of the genes identified in this study had previously been associated with salt stress However the majority were novel indicating that there is a great number of genes that are induced by salt exposure Analysis of the salt stress expression profile data of Nona provided clues regarding some putative cellular and molecular processes that are undertaken by this tolerant rice variety in response to salt stress Namely we found that multiple transcription factors were induced during the initial salt response of shoots Many genes whose encoded proteins are implicated in detoxification protectant and transport were rapidly induced Genes supporting photosynthesis were repressed and those supporting carbohydrate metabolism were altered Commonality among the genes induced by salt exposure

    Original URL path: http://www.cell-research.com/arts.asp?id=1136 (2016-02-14)
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  • Cell Research
    1 Olga M MOISEEVA 2 Anton L EVDONIN 1 Kirill A KONDRATOV 1 Natalja D MEDVEDEVA 1 1 Institute of Cytology Russian Academy of Sciences St Petersburg 196064 Russia 2 Almazovs Research Institute of Cardiology St Petersburg 194056 Russia Received Jun 30 2005 Revised Sep 13 2005 Accepted Oct 12 2005 Correspondence Marina G MARTYNOVA E mail heartdev mail cytspb rssi ru Atrial natriuretic peptide ANP is an important component of the natriuretic peptide system A great role in many regulatory systems is played by mast cells Meanwhile involvement of these cells in ANP activity is poorly studied In this work we have shown the presence of ANP in rat peritoneal mast cells Pure fraction of mast cells was obtained by separation of rat peritoneal cells on a Percoll density gradient By Western blotting two ANP immunoreactive proteins of molecular masses of 2 5 kDa and 16 9 kDa were detected in lysates from these mast cells Electron microscope immunogold labeling has revealed the presence of ANP immunoreactive material in storage secreting and released granules of mast cells Our findings indicate the rat peritoneal mast cells to contain both ANP prohormone and ANP These both peptides are located in mast

    Original URL path: http://www.cell-research.com/arts.asp?id=1137 (2016-02-14)
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  • Cell Research
    526 Thomson Reuters 2013 Free Sample Issue Submission Advanced Online Publication Current Issue Top 10 VOLUME 15 ISSUE 11 11 2005 821 822 An editorial overview HIV AIDS in China Richard Y ZHAO University of Maryland School of Medicine 10 South Pine Street MSTF 700A Baltimore Maryland 21201 USA Correspondence Richard Y ZHAO Tel 410 706 6301 E mail rzhao som umaryland edu Cell Research 2005 15 821 822 doi

    Original URL path: http://www.cell-research.com/arts.asp?id=1671 (2016-02-14)
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