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  • Cell Research
    Huang 1 1 The Walter and Eliza Hall Institute of Medical Research 1G Royal Parade Parkville Victoria 3050 Australia 2 Department of Medical Biology University of Melbourne Parkville Victoria 3010 Australia Correspondence David CS Huang E mail huang d wehi edu au Commitment of cells to apoptosis is governed largely by protein protein interactions between members of the Bcl 2 protein family Its three sub families have distinct roles the BH3 only proteins trigger apoptosis by binding via their BH3 domain to pro survival relatives while the pro apoptotic Bax and Bak have an essential downstream role involving disruption of organellar membranes and induction of caspase activation The BH3 only proteins act as damage sensors held inert until their activation by stress signals Once activated they were thought to bind promiscuously to pro survival protein targets but unexpected selectivity has recently emerged from analysis of their interactions Some BH3 only proteins also bind to Bax and Bak Whether Bax and Bak are activated directly by these BH3 only proteins or indirectly as a consequence of BH3 only proteins neutralizing their pro survival targets is the subject of intense debate Regardless of this a detailed understanding of the interactions between family

    Original URL path: http://www.cell-research.com/arts.asp?id=1112 (2016-02-14)
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  • Cell Research
    University School of Medicine 635 Barnhill Drive MS 420 Indianapolis IN 46202 5120 USA Correspondence Xin Yuan Fu Tel 317 274 2082 E mail xfu IUPUI edu STAT3 has been known as a mediator for gene expression induced by many important cytokines Recent studies have suggested that STAT3 has important functions in regulation of both innate and adaptive immunity Loss of STAT3 in immune cells caused severe inflammation in response

    Original URL path: http://www.cell-research.com/arts.asp?id=1113 (2016-02-14)
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  • Cell Research
    Toronto Ontario M5G 2M1 Canada Correspondence Eleanor N Fish Tel 416 340 5380 E mail en fish utoronto ca Interferon IFN αs bind to and activate their cognate cell surface receptor to invoke an antiviral response in target cells Well described receptor mediated signaling events result in transcriptional regulation of IFN sensitive genes effectors of this antiviral response Results from a pilot study to evaluate the clinical efficacy of IFN α treatment of SARS patients provided evidence for IFN inducible resolution of disease In this report we examined the contribution of IFN inducible phosphorylation activation of specific signaling effectors to protection from infection by a SARS related murine coronavirus MHV 1 As anticipated the earliest receptor activation event Jak1 phosphorylation is critical for IFN inducible protection from MHV 1 infection Additionally we provide evidence for the contribution of two kinases the MAP kinase p38MAPK and protein kinase C PKC d to antiviral protection from MHV 1 infection Notably our data suggest that MHV 1 infection as for the Urbani SARS coronoavirus inhibits an IFN response inferred from the lack of activation of pkr and 2 5 oas genes associated with mediating the antiviral activities of IFN αs To identify potential

    Original URL path: http://www.cell-research.com/arts.asp?id=1114 (2016-02-14)
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  • Cell Research
    Japan 2 Department of Experimental Therapeutics Translational Research Center Kyoto University Hospital 54 Shogoin Kawahara cho Sakyo ku Kyoto 606 8507 Japan 3 Research Unit for Clinical Allergy RIKEN Research Center for Allergy and Immunology 1 7 22 Suehiro cho Tsurumi ku Yokohama 230 0045 Japan Correspondence Junji Yodoi Tel 81 75 751 4024 E mail yodoi virus kyoto u ac jp Thioredoxin 1 TRX is a stress inducible redox regulatory protein with antioxidative and anti inflammatory effects Here we show that the release of histamine from mast cells elicited by cross linking of high affinity receptor for IgE FcεRI was significantly suppressed in TRX transgenic TRX tg mice compared to wild type WT mice Intracellular reactive oxygen species ROS of mast cells stimulated by IgE and antigen was also reduced in TRX tg mice compared to WT mice Whereas there was no difference in the production of cytokines IL 6 and TNF α from mast cells in response to 2 4 dinitrophenylated bovine serum albumin DNP BSA stimulation in TRX tg and WT mice Immunological status of TRX tg mice inclined to T helper Th 2 dominant in primary immune response although there was no difference in the population

    Original URL path: http://www.cell-research.com/arts.asp?id=1115 (2016-02-14)
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  • Cell Research

    (No additional info available in detailed archive for this subpage)
    Original URL path: /artsmore1.asp?id=90 (2016-02-14)


  • Cell Research
    immunology and biotechnology have made cancer gene therapy and immunotherapy feasible The current efforts for cancer gene therapy mainly focus on using immunogenes chemogenes and tumor suppressor genes Central to all these therapies is the development of efficient vectors for gene therapy By far adenovirus AdV mediated gene therapy is one of the most promising approaches as has confirmed by studies relating to animal tumor models and clinical trials Dendritic cells DCs are highly efficient specialized antigen presenting cells and DCbased tumor vaccines are regarded as having much potential in cancer immunotherapy Vaccination with DCs pulsed with tumor peptides lysates or RNA or loaded with apoptotic necrotic tumor cells or engineered to express certain cytokines or chemokines could induce significant antitumor cytotoxic T lymphocyte CTL responses and antitumor immunity Although both AdV mediated gene therapy and DC vaccine can both stimulate antitumor immune responses their therapeutic efficiency has been limited to generation of prophylactic antitumor immunity against re challenge with the parental tumor cells or to growth inhibition of small tumors However this approach has been unsuccessful in combating well established tumors in animal models Therefore a major strategic goal of current cancer immunotherapy has become the development of novel

    Original URL path: http://www.cell-research.com/arts.asp?id=1088 (2016-02-14)
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  • Cell Research
    and Technology Wuhan 430074 China Correspondence Guang Cun He Yun Chun Song Tel 86 27 87641314 E mail gche whu edu cn songyc1936 yahoo com cn The genomic structures of Oryza sativa A genome and O meyeriana G genome were comparatively studied using bicolor genomic in situ hybridization GISH GISH was clearly able to discriminate between the chromosomes of O sativa and O meyeriana in the interspecific F1 hybrids without blocking DNA and co hybridization was hardly detected The average mitotic chromosome length of O meyeriana was found to be 1 69 times that of O sativa A comparison of 4 6 diamidino 2 phenylindole staining showed that the chromosomes of O meyeriana were more extensively labelled suggesting that the G genome is amplified with more repetitive sequences than the A genome In interphase nuclei 9 12 chromocenters were normally detected and nearly all the chromocenters constituted the G genome specific DNA More and larger chromocenters formed by chromatin compaction corresponding to the G genome were detected in the hybrid compared with its parents During pachytene of the F1 hybrid most chromosomes of A and G did not synapse each other except for 1 2 chromosomes paired at the end

    Original URL path: http://www.cell-research.com/arts.asp?id=1089 (2016-02-14)
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  • Cell Research
    Biology Chinese Academy of Sciences Beijing 100101 China 2 State Key Laboratory of Rice Biology China National Rice Research Institute Chinese Academy of Agricultural Sciences Hangzhou 310006 China 3 Graduate University of Chinese Academy of Sciences Beijing 100049 China Correspondence Yong Hong Wang Qian Qian Tel 86 10 64889377 E mail yhwang genetics ac cn qianqian188 hotmail com During vegetative development higher plants continuously form new leaves in regular spatial and temporal patterns Mutants with abnormal leaf developmental patterns not only provide a great insight into understanding the regulatory mechanism of plant architecture but also enrich the ways to its modification by which crop yield could be improved Here we reported the characterization of the rice leafy head2 lhd2 mutant that exhibits shortened plastochron dwarfism reduced tiller number and failure of phase transition from vegetative to reproductive growth Anatomical and histological study revealed that the rapid emergence of leaves in lhd2 was resulted from the rapid initiation of leaf primordia whereas the reduced tiller number was a consequence of the suppression of the tiller bud outgrowth The molecular and genetic analysis showed that LHD2 encodes a putative RNA binding protein with 67 similarity to maize TE1 Comparison of genome scale

    Original URL path: http://www.cell-research.com/arts.asp?id=1090 (2016-02-14)
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