archive-com.com » COM » C » CELL-RESEARCH.COM

Total: 1754

Choose link from "Titles, links and description words view":

Or switch to "Titles and links view".
  • Cell Research
    the salt mine expands FREE Liliana E Lucca 1 and David A Hafler 1 1 Department of Neurology and Immunobiology Yale School of Medicine New Haven CT 06511 USA Correspondence David Hafler E mail david hafler yale edu High sodium consumption has been raising interest as a putative environmental factor linking Western lifestyle to the growing epidemic of autoimmune and inflammatory diseases Now Zhang and colleagues show that high sodium

    Original URL path: http://www.cell-research.com/arts.asp?id=2146 (2016-02-14)
    Open archived version from archive


  • Cell Research
    8 8 2015 887 888 Cancer immunotherapy exploiting neoepitopes FREE Michael Platten 1 2 and Rienk Offringa 3 4 1 DKTK Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology German Cancer Research Center Heidelberg Germany 2 Neurology Clinic University Hospital Heidelberg and National Center for Tumor Diseases Heidelberg Germany 3 Dept Molecular Oncology of Gastrointestinal Tumors German Cancer Research Center Heidelberg Germany 4 European Pancreas Center Surgery Clinic University Hospital

    Original URL path: http://www.cell-research.com/arts.asp?id=2136 (2016-02-14)
    Open archived version from archive

  • Cell Research
    Thomson Reuters 2013 Free Sample Issue Submission Advanced Online Publication Current Issue Top 10 VOLUME 25 ISSUE 8 8 2015 889 890 rsPSCs A new type of pluripotent stem cells FREE Uri Weissbein 1 and Nissim Benvenisty 1 1 The Azrieli Center for Stem Cells and Genetic Research Department of Genetics Silberman Institute of Life Sciences The Hebrew University Jerusalem 91904 Israel Correspondence Nissim Benvenisty E mail nissimb mail huji

    Original URL path: http://www.cell-research.com/arts.asp?id=2137 (2016-02-14)
    Open archived version from archive

  • Cell Research
    factor 10 526 Thomson Reuters 2013 Free Sample Issue Submission Advanced Online Publication Current Issue Top 10 VOLUME 25 ISSUE 8 8 2015 891 892 A frightening thought Neuronal activity enhances tumor growth FREE Emily G Thompson 1 and Harald Sontheimer 1 1 Department of Neurobiology Center for Glial Biology in Medicine University of Alabama at Birmingham Birmingham AL 35209 USA Correspondence Harald Sontheimer E mail sontheimer uab edu 10

    Original URL path: http://www.cell-research.com/arts.asp?id=2138 (2016-02-14)
    Open archived version from archive

  • Cell Research
    Zhong Duan 1 1 Key Laboratory of Nutrition and Metabolism Institute for Nutritional Sciences Shanghai Institutes for Biological Sciences Chinese Academy of Sciences University of the Chinese Academy of Sciences Shanghai 200031 China 2 Shanghai Key Laboratory of Stomatology Department of Oral and Maxillofacial Head Neck Oncology Ninth People s Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200011 China 3 Department of Cardiology Shanghai Chest Hospital Shanghai Jiao Tong University Shanghai 200030 China 4 Department of Hypertension and Vascular Disease The First Affiliated Hospital Sun Yat Sen University Guangzhou Guangdong 510080 China 5 Cancer Institute Fudan University Shanghai Cancer Center Fudan University Shanghai 200032 China 6 Life Sciences Institute and Innovation Center for Cell Biology Zhejiang University Hangzhou Zhejiang 310058 China 7 State Key Laboratory of Cell Biology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China 8 Department of Pathology Tongji Hospital Tongji University School of Medicine Shanghai 200065 China 9 Laboratory of Cardiovascular Diseases Regenerative Medicine Research Center West China Hospital Sichuan University Chengdu Sichuan 610041 China 10 Department of Pathology University Medical Center of Princeton Plainsboro NJ USA 11 Department of Chemical Biology Ernest Mario School of Pharmacy Rutgers University Piscataway NJ USA 12 Department of Pathology Robert Wood Johnson Medical School Rutgers University Piscataway NJ USA 13 Cancer Institute of New Jersey Rutgers University Piscataway NJ 08854 8020 USA Correspondence Sheng Zhong Duan Tel Fax 86 21 5492 0981 E mail szduan sibs ac cn High salt is positively associated with the risk of many diseases However little is known about the mechanisms Here we showed that high salt increased proinflammatory molecules while decreased anti inflammatory and proendocytic molecules in both human and mouse macrophages High salt also potentiated lipopolysaccharide induced macrophage activation and suppressed

    Original URL path: http://www.cell-research.com/arts.asp?id=2139 (2016-02-14)
    Open archived version from archive

  • Cell Research
    3 Garwin Pichler 1 3 6 David Hörl 1 3 4 Karin Fellinger 1 3 7 Fabio Spada 1 3 8 Ian Marc Bonapace 5 Axel Imhof 2 3 Hartmann Harz 1 3 4 and Heinrich Leonhardt 1 3 4 1 Department of Biology II Ludwig Maximilians University Munich Großhaderner Str 2 82152 Planegg Martinsried Germany 2 Adolf Butenandt Institute Ludwig Maximilians University Munich Schillerstr 44 80336 Munich Germany 3 Center for Integrated Protein Science Munich CIPSM Via Manara 7 21052 Busto Arsizio VA Italy 4 Nanosystems Initiative Munich NIM Via Manara 7 21052 Busto Arsizio VA Italy 5 Department of Theoretical and Applied Sciences University of Insubria Via Manara 7 21052 Busto Arsizio VA Italy 6 Current address Department of Proteomics and Signal Transduction Max Planck Institute of Biochemistry Martinsried Germany 7 Current address Intervet International GmbH Unterschleissheim Germany 8 Current address Department of Chemistry Ludwig Maximilians University Munich Germany Correspondence Heinrich Leonhardt E mail h leonhardt lmu de DNMT1 is recruited by PCNA and UHRF1 to maintain DNA methylation after replication UHRF1 recognizes hemimethylated DNA substrates via the SRA domain but also repressive H3K9me3 histone marks with its TTD With systematic mutagenesis and functional assays we could show that chromatin binding further involved UHRF1 PHD binding to unmodified H3R2 These complementation assays clearly demonstrated that the ubiquitin ligase activity of the UHRF1 RING domain is required for maintenance DNA methylation Mass spectrometry of UHRF1 deficient cells revealed H3K18 as a novel ubiquitination target of UHRF1 in mammalian cells With bioinformatics and mutational analyses we identified a ubiquitin interacting motif UIM in the N terminal regulatory domain of DNMT1 that binds to ubiquitinated H3 tails and is essential for DNA methylation in vivo H3 ubiquitination and subsequent DNA methylation required UHRF1 PHD binding to H3R2 These results show the

    Original URL path: http://www.cell-research.com/arts.asp?id=2140 (2016-02-14)
    Open archived version from archive

  • Cell Research
    Ding 3 Lei Qiu 2 Zhen Lin Hu 2 Xin Zhang 1 Hong Yang Wang 3 Jun Ping Zhang 2 and Wei Fen Xie 1 1 Department of Gastroenterology Changzheng Hospital Second Military Medical University Shanghai 200003 China 2 Department of Biochemical Pharmacology School of Pharmacy Second Military Medical University Shanghai 200433 China 3 The International Cooperation Laboratory on Signal Transduction of Eastern Hepatobiliary Surgery Institute Second Military Medical University Shanghai 200433 China 4 Current address Department of Gastroenterology 411th Hospital of PLA Shanghai 200081 China Correspondence Wei Fen Xie Tel 86 21 81885341 Fax 86 21 8188 6924 E mail weifenxie medmail com cn Jun Ping Zhang Tel 86 21 81871328 E mail jpzhang08 hotmail com Hepatocytes are critical for the maintenance of liver homeostasis but its involvement in hepatic fibrogenesis remains elusive Hepatocyte nuclear factor 1α HNF1α is a liver enriched transcription factor that plays a key role in hepatocyte function Our previous study revealed a significant inhibitory effect of HNF1α on hepatocellular carcinoma In this study we report that the expression of HNF1α is significantly repressed in both human and rat fibrotic liver Knockdown of HNF1α in the liver significantly aggravates hepatic fibrogenesis in either dimethylnitrosamine DMN or bile duct ligation BDL model in rats In contrast forced expression of HNF1α markedly alleviates hepatic fibrosis HNF1α regulates the transcriptional expression of SH2 domain containing phosphatase 1 SHP 1 via directly binding to SHP 1 promoter in hepatocytes Inhibition of SHP 1 expression abrogates the anti fibrotic effect of HNF1α in DMN treated rats Moreover HNF1α repression in primary hepatocytes leads to the activation of NF κB and JAK STAT pathways and initiates an inflammatory feedback circuit consisting of HNF1α SHP 1 STAT3 p65 miR 21 and miR 146a which sustains the deregulation of HNF1α in hepatocytes More

    Original URL path: http://www.cell-research.com/arts.asp?id=2141 (2016-02-14)
    Open archived version from archive

  • Cell Research
    and Weijun Pan 1 9 1 Key Laboratory of Stem Cell Biology Institute of Health Sciences Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai Jiao Tong University School of Medicine Shanghai China 2 State Key Laboratory for Medical Genomics Shanghai Institute of Hematology RuiJin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China 3 Stem Cell Program Hematology Oncology Program at Children s Hospital Boston Harvard Medical School Boston MA 02114 USA 4 Biomedical Research Center Baotou Medical College Baotou Inner Mongolia Autonomous Region China 5 Institute of Neuroscience Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai China 6 Key Laboratory of Metabolism and Molecular Medicine Ministry of Education Department of Biochemistry and Molecular Biology School of Basic Medical Sciences Fudan University Shanghai China 7 CNRS LIA Shanghai Institute of Hematology RuiJin Hospital 197 RuiJin Road II Shanghai China 8 Key Laboratory of Freshwater Fish Reproduction and Development Ministry of Education Laboratory of Molecular Developmental Biology School of Life Sciences Southwest University Beibei Chongqing China 9 Collaborative Innovation Center of Systems Biomedicine Shanghai Jiao Tong University School of Medicine Shanghai China Correspondence Weijun Pan E mail weijunpan sibs ac cn Saijuan Chen E mail sjchen stn sh cn Yi Zhou E mail yzhou enders tch harvard edu Dysregulation of ribosome biogenesis causes human diseases such as Diamond Blackfan anemia del 5q syndrome and bone marrow failure However the mechanisms of blood disorders in these diseases remain elusive Through genetic mapping molecular cloning and mechanism characterization of the zebrafish mutant cas002 we reveal a novel connection between ribosomal dysfunction and excessive autophagy in the regulation of hematopoietic stem progenitor cells HSPCs cas002 carries a recessive lethal mutation in kri1l gene that encodes an essential component of rRNA small subunit processome We show that Kri1l is required

    Original URL path: http://www.cell-research.com/arts.asp?id=2142 (2016-02-14)
    Open archived version from archive



  •