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  • Cell Research
    Lawrence Berkeley National Laboratory Berkeley CA 94720 USA Correspondence Ehud Y Isacoff Tel 510 642 9853 E mail ehud berkeley edu Calcium flux through store operated calcium entry is a major regulator of intracellular calcium homeostasis and various calcium signaling pathways Two key components of the store operated calcium release activated calcium channel are the Ca2 sensing protein stromal interaction molecule 1 STIM1 and the channel pore forming protein Orai1 Following calcium depletion from the endoplasmic reticulum STIM1 undergoes conformational changes that unmask an Orai1 activating domain called CAD CAD binds to two sites in Orai1 one in the N terminal and one in the C terminal Most previous studies suggested that gating is initiated by STIM1 binding at the Orai1 N terminal site just proximal to the TM1 pore lining segment and that binding at the C terminal simply anchors STIM1 within reach of the N terminal However a recent study had challenged this view and suggested that the Orai1 C terminal region is more than a simple STIM1 anchoring site In this study we establish that the Orai1 C terminal domain plays a direct role in gating We identify a linker region between TM4 and the C terminal

    Original URL path: http://www.cell-research.com/arts.asp?id=2143 (2016-02-14)
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  • Cell Research
    Center and Institutes of Biomedical Sciences Shanghai Medical College Fudan University Shanghai 200032 China 2 State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer Institute Renji Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200032 China Correspondence Shenglin Huang Tel 86 21 3477 7580 Fax 86 21 6417 2585 E mail slhuang fudan edu cn Xianghuo He E mail xhhe fudan edu cn Circular RNAs circRNAs are recently identified as a naturally occurring family of widespread and diverse endogenous noncoding RNAs that may regulate gene expression in mammals1 2 3 4 They are unusually stable RNA molecules with cell type or developmental stage specific expression patterns3 5 Exosomes are small membrane vesicles of endocytic origin secreted by most cell types They contain a specific cargo of protein mRNA and microRNA species which can modulate recipient cell behaviors and may be used as biomarkers for diagnosis of human diseases6 Here we show for the first time the presence of abundant circRNAs in exosomes RNA seq analyses revealed that circRNAs were enriched in exosomes compared to the producer cells Furthermore the sorting of circRNAs to exosomes may be regulated by changes of associated miRNA levels in producer cells and may

    Original URL path: http://www.cell-research.com/arts.asp?id=2144 (2016-02-14)
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  • Cell Research
    Submission Advanced Online Publication Current Issue Top 10 VOLUME 25 ISSUE 8 8 2015 985 988 Opposing roles of conventional and novel PKC isoforms in Hippo YAP pathway regulation Rui Gong 1 2 3 Audrey W Hong 1 Steven W Plouffe 1 Bin Zhao 4 Guangbo Liu 1 Fa Xing Yu 5 Yanhui Xu 1 2 3 and Kun Liang Guan 1 1 Department of Pharmacology and Moores Cancer Center University of California San Diego La Jolla CA 92093 USA 2 Department of Oncology Fudan University Shanghai Cancer Center Shanghai 200032 China 3 Institute of Biomedical Sciences Shanghai Medical College of Fudan University Shanghai 200032 China 4 Life Sciences Institute and Innovation Center for Cell Biology Zhejiang University Hangzhou Zhejiang 310058 China 5 Children s Hospital and Institutes of Biomedical Sciences Fudan University Shanghai 200032 China Correspondence Fa Xing Yu E mail fxyu fudan edu cn Yanhui Xu E mail xuyh fudan edu cn Kun Liang Guan E mail kuguan ucsd edu The Hippo YAP pathway is an evolutionally conserved signaling module that controls tissue growth during development and its dysregulation causes cancer1 Core components of the Hippo pathway include a kinase cascade comprising MST1 2 and LATS1 2 kinases

    Original URL path: http://www.cell-research.com/arts.asp?id=2145 (2016-02-14)
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  • Cell Research

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    Original URL path: /artsmore1.asp?id=186 (2016-02-14)


  • Cell Research
    7 2015 761 762 Mimicking the niche cytokines expand muscle stem cells FREE Marco Quarta 1 2 3 and Thomas A Rando 1 2 3 1 Department of Neurology and Neurological Sciences Stanford University School of Medicine Stanford CA 94305 USA 2 Paul F Glenn Center for the Biology of Aging Stanford University School of Medicine Stanford CA 94305 USA 3 Center for Tissue Regeneration Repair and Restoration Veterans Affairs

    Original URL path: http://www.cell-research.com/arts.asp?id=2121 (2016-02-14)
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  • Cell Research
    impact factor 10 526 Thomson Reuters 2013 Free Sample Issue Submission Advanced Online Publication Current Issue Top 10 VOLUME 25 ISSUE 7 7 2015 763 764 A price to pay for tumor regression FREE Rene Bernards 1 1 Division of Molecular Carcinogenesis and Cancer Genomics Center Netherlands The Netherlands Cancer Institute Plesmanlaan 121 1066 CX Amsterdam The Netherlands Correspondence Rene Bernards E mail r bernards nki nl 10 1038 cr

    Original URL path: http://www.cell-research.com/arts.asp?id=2122 (2016-02-14)
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  • Cell Research
    Medicine Hadassah Hebrew University Medical Center 91120 Jerusalem Israel 2 Thoracic Oncology Research Laboratory University of Pennsylvania Philadelphia PA 19104 USA 3 Department of Developmental Biology and Cancer Research Institute for Medical Research Israel Canada Hebrew University Medical School 91120 Jerusalem Israel Correspondence Zvi Granot E mail zvikag ekmd huji ac il Steven M Albelda E mail albelda mail med upenn edu Zvi G Fridlender E mail E mail Fridlender

    Original URL path: http://www.cell-research.com/arts.asp?id=2133 (2016-02-14)
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  • Cell Research
    1 and Xiao Jiang Li 1 2 1 Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 China 2 Department of Human Genetics Emory University School of Medicine Atlanta GA 30322 USA Correspondence Xiao Jiang Li E mail xli2 emory edu Mosaic mutations and off target effects caused by CRISPR Cas9 have led to concerns about the efficiency and specificity of this new technique in non human

    Original URL path: http://www.cell-research.com/arts.asp?id=2134 (2016-02-14)
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