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  • Cell Research
    Sample Issue Submission Advanced Online Publication Current Issue Top 10 VOLUME 25 ISSUE 7 7 2015 769 770 DNA damage and gene transcription accident or necessity FREE Miguel Beato 1 Roni H Wright 1 and Guillermo P Vicent 1 1 Center for Genomic Regulation CRG Dr Aiguader 88 E 08003 Barcelona Spain University Pompeu Fabra UPF E 08803 Barcelona Spain Correspondence Miguel Beato Guillermo P Vicent E mail miguel beato

    Original URL path: http://www.cell-research.com/arts.asp?id=2123 (2016-02-14)
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  • Cell Research
    Advanced Online Publication Current Issue Top 10 VOLUME 25 ISSUE 7 7 2015 771 784 Metabolic reprogramming in macrophages and dendritic cells in innate immunity OPEN Beth Kelly 1 and Luke AJ O Neill 1 1 School of Biochemistry and Immunology Trinity Biomedical Sciences Institute Trinity College Dublin Ireland Correspondence Beth Kelly E mail kellyb3 tcd ie Activation of macrophages and dendritic cells DCs by pro inflammatory stimuli causes them to undergo a metabolic switch towards glycolysis and away from oxidative phosphorylation OXPHOS similar to the Warburg effect in tumors However it is only recently that the mechanisms responsible for this metabolic reprogramming have been elucidated in more detail The transcription factor hypoxia inducible factor 1α HIF 1α plays an important role under conditions of both hypoxia and normoxia The withdrawal of citrate from the tricarboxylic acid TCA cycle has been shown to be critical for lipid biosynthesis in both macrophages and DCs Interference with this process actually abolishes the ability of DCs to activate T cells Another TCA cycle intermediate succinate activates HIF 1α and promotes inflammatory gene expression These new insights are providing us with a deeper understanding of the role of metabolic reprogramming in innate immunity 10

    Original URL path: http://www.cell-research.com/arts.asp?id=2124 (2016-02-14)
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  • Cell Research
    Geriatric the State Key Laboratory of Kidney Beijing 100853 the Provincial Key Laboratory of Biotechnology Guangdong 510006 China 2 State Key Laboratory of Oncology in Southern China Sun Yat Sen University Cancer Center Guangzhou Guangdong 510060 China 3 Wuhan Institute of Virology Chinese Academy of Sciences Wuhan Hubei 430071 China 4 School of Ophthalmology and Optometry Wenzhou Medical University Wenzhou Zhejiang 325000 China 5 State Key Laboratory of Biotherapy West China Hospital Sichuan University Chengdu Sichuan 610041 China 6 The Second Affiliated Hospital Guangzhou Medical University Guangzhou Guangdong 510260 China 7 Laboratory of Cell Engineering Institute of Biotechnology Beijing 100071 China 8 Institute of Molecular Immunology School of Biotechnology Southern Medical University Guangzhou Guangdong 510515 China 9 Department of Immunology and Microbiology Shanghai Institute of Immunology Shanghai Jiaotong University School of Medicine Shanghai 200025 China Correspondence Xiaoning Wang Ying Wang E mail xnwang88 163 com ywang sibs ac cn Epstein Barr virus EBV can infect both susceptible B lymphocytes and non susceptible epithelial cells ECs Viral tropism analyses have revealed two intriguing means of EBV infection either by a receptor mediated infection of B cells or by a cell to cell contact mediated infection of non susceptible ECs Herein we report a novel in cell infection mechanism for EBV infection of non susceptible ECs through the formation of cell in cell structures Epithelial CNE 2 cells were invaded by EBV infected Akata B cells to form cell in cell structures in vitro Such unique cellular structures could be readily observed in the specimens of nasopharyngeal carcinoma Importantly the formation of cell in cell structures led to the autonomous activation of EBV within Akata cells and subsequent viral transmission to CNE 2 cells as evidenced by the expression of viral genes and the presence of virion particles in CNE 2 cells

    Original URL path: http://www.cell-research.com/arts.asp?id=2125 (2016-02-14)
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  • Cell Research
    Hong Kong China 2 Center of Systems Biology and Human Health School of Science and Institute for Advanced Study Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China 3 State Key Laboratory of Medicinal Chemical Biology Nankai University 94 Weijin Road Tianjin 300071 China 4 College of Life Sciences Nankai University 94 Weijin Road Tianjin 300071 China 5 Institute of Molecular and Cell Biology Agency for Science Technology and Research A STAR 61 Biopolis Drive Proteos Singapore 138673 Singapore 6 Department of Biology South University of Science and Technology of China Shenzhen Guangdong 518055 China Correspondence Jiafu Long Mingjie Zhang E mail jflong nankai edu cn mzhang ust hk The tumor suppressor Merlin NF2 functions upstream of the core Hippo pathway kinases Lats1 2 and Mst1 2 as well as the nuclear E3 ubiquitin ligase CRL4DCAF1 Numerous mutations of Merlin have been identified in Neurofibromatosis type 2 and other cancer patients Despite more than two decades of research the upstream regulator of Merlin in the Hippo pathway remains unknown Here we show by high resolution crystal structures that the Lats1 2 binding site on the Merlin FERM domain is physically blocked by Merlin s auto

    Original URL path: http://www.cell-research.com/arts.asp?id=2126 (2016-02-14)
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  • Cell Research
    Jia sheng Wang 1 Fei Xu 1 Wei Lu 3 Shuang Qiu 1 Wei Yang 1 and Jian hong Luo 1 1 Department of Neurobiology Key Laboratory of Medical Neurobiology Ministry of Health of China Collaborative Innovation Center for Brain Science Zhejiang University School of Medicine Hangzhou Zhejiang 310058 China 2 Department of Physiology Kunming Medical University Kunming Yunnan 650500 China 3 Key Laboratory of Developmental Genes and Human Disease Ministry of Education of China Institute of Life Sciences Southeast University Nanjing Jiangsu 211189 China Correspondence Jian hong Luo Wei Yang Shuang Qiu E mail luojianhong zju edu cn yangwei zju edu cn qiushly zju edu cn The N methyl D aspartate receptor NMDAR in adult forebrain is a heterotetramer mainly composed of two GluN1 subunits and two GluN2A and or GluN2B subunits The synaptic expression and relative numbers of GluN2A and GluN2B containing NMDARs play critical roles in controlling Ca2 dependent signaling and synaptic plasticity Previous studies have suggested that the synaptic trafficking of NMDAR subtypes is differentially regulated but the precise molecular mechanism is not yet clear In this study we demonstrated that Bip an endoplasmic reticulum ER chaperone selectively interacted with GluN2A and mediated the neuronal activity

    Original URL path: http://www.cell-research.com/arts.asp?id=2127 (2016-02-14)
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  • Cell Research
    Planck Institute for Heart and Lung Research Parkstrasse 1 61231 Bad Nauheim Germany 2 The Massachusetts General Hospital Cancer Center Harvard Medical School Boston MA 02118 USA 3 Division of Biomolecular Mass Spectrometry Max Planck Institute for Heart and Lung Research Parkstrasse 1 61231 Bad Nauheim Germany 4 Group of Bioinformatics Max Planck Institute for Heart and Lung Research Parkstrasse 1 61231 Bad Nauheim Germany 5 Department of Medicine Cedars Sinai Medical Center Los Angeles CA 90048 USA 6 Chair for Lung Matrix Remodeling Excellence Cluster Cardio Pulmonary System University Justus Liebig 35932 Giessen Germany 7 Department of Lung Development and Remodeling Max Planck Institute for Heart and Lung Research Parkstrasse 1 61231 Bad Nauheim Germany 8 Department of Cardiac Development and Remodeling Max Planck Institute for Heart and Lung Research Parkstrasse 1 61231 Bad Nauheim Germany 9 Institute of Fundamental Medicine and Biology Kazan Volga Region Federal University 420008 Kazan Russian Federation 10 Member of the Universities of Giessen and Marburg Lung Center UGMLC and the German Center of Lung Research Deutsches Zentrum für Lungenforschung DZL Correspondence Guillermo Barreto E mail guillermo barreto mpi bn mpg de The eukaryotic genome is organized into chromatins the physiological template for DNA dependent processes including replication recombination repair and transcription Chromatin mediated transcription regulation involves DNA methylation chromatin remodeling and histone modifications However chromatin also contains non histone chromatin associated proteins of which the high mobility group HMG proteins are the most abundant Although it is known that HMG proteins induce structural changes of chromatin the processes underlying transcription regulation by HMG proteins are poorly understood Here we decipher the molecular mechanism of transcription regulation mediated by the HMG AT hook 2 protein HMGA2 We combined proteomic ChIP seq and transcriptome data to show that HMGA2 induced transcription requires phosphorylation of the

    Original URL path: http://www.cell-research.com/arts.asp?id=2128 (2016-02-14)
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  • Cell Research
    Feng 2 3 Mingming Xie 2 5 Tiantian Gu 2 Tao Zhou 1 Rui Fu 2 Xingxu Huang 6 Qi Zhou 2 Jiahao Sha 1 and Xiao Yang Zhao 2 1 State Key Laboratory of Reproductive Medicine Department of Histology and Embryology Nanjing Medical University Nanjing Jiangsu 210029 China 2 State Key Laboratory of Reproductive Biology Institute of Zoology Chinese Academy of Sciences Beijing 100101 China 3 Graduate School of Chinese Academy of Sciences Beijing 100049 China 4 College of Life Sciences Hunan Normal University Changsha Hunan 410081 China 5 College of Life Science Anhui University of China Hefei Anhui 230601 China 6 MOE Key Laboratory of Model Animal for Disease Study Model Animal Research Center of Nanjing University Nanjing Biomedical Research Institute National Resource Center for Mutant Mice Nanjing Jiang Su 210061 China Correspondence Qi Zhou Jiahao Sha Xiao Yang Zhao E mail qzhou ioz ac cn shajh njmu edu cn xyzhao ioz ac cn Genetic mutations could cause sperm deficiency leading to male infertility Without functional gametes in the testes patients cannot produce progeny even with assisted reproduction technologies such as in vitro fertilization It has been a major challenge to restore the fertility of gamete deficient patients due to genetic mutations In this study using a Kit w Kit wv mouse model we investigated the feasibility of generating functional sperms from gamete deficient mice by combining the reprogramming and gene correcting technologies We derived embryonic stem cells from cloned embryos ntESCs that were created by nuclear transfer of Kit w Kit wv somatic cells Then we generated gene corrected ntESCs using TALEN mediated gene editing The repaired ntESCs could further differentiate into primordial germ cell like cells PGCLCs in vitro RFP labeled PGCLCs from the repaired ntESCs could produce functional sperms in mouse testes In addition by

    Original URL path: http://www.cell-research.com/arts.asp?id=2129 (2016-02-14)
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  • Cell Research
    National Center for Plant Gene Research Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 China 2 State Key Laboratory of Crop Biology College of Life Sciences Shandong Agricultural University Taian Shandong 271018 China 3 Center for Genome Analysis ABLife Inc Novonest Building 8 Nanhu Avenue East Lake Hi Tech Development Zone Wuhan Hubei 430064 China 4 Collaborative Innovation Center of Genetics and Development Shanghai 200433 China Correspondence Chunyan Liu Xiaofeng Cao E mail cyliu genetics ac cn xfcao genetics ac cn Alternative polyadenylation APA is a widespread mechanism for gene regulation and has been implicated in flowering but the molecular basis governing the choice of a specific poly A site during the vegetative to reproductive growth transition remains unclear Here we characterize HLP1 an hnRNP A B protein as a novel regulator for pre mRNA 3 end processing in Arabidopsis Genetic analysis reveals that HLP1 suppresses Flowering Locus C FLC a key repressor of flowering in Arabidopsis Genome wide mapping of HLP1 RNA interactions indicates that HLP1 binds preferentially to A rich and U rich elements around cleavage and polyadenylation sites implicating its role in 3 end formation We show HLP1 is significantly enriched at transcripts

    Original URL path: http://www.cell-research.com/arts.asp?id=2130 (2016-02-14)
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