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  • Cell Research
    Man Sun 1 Bin Shen 3 Hui Jiang 1 Nannan Kang 4 Jimin Gao 4 Xingxu Huang 1 2 and Jianghuai Liu 1 1 State Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animals for Disease Study Model Animal Research Center of Nanjing University Nanjing Jiangsu 210061 China 2 School of Life Science and Technology ShanghaiTech University 100 Haike Rd Pudong New Area Shanghai 201210 China 3

    Original URL path: http://www.cell-research.com/arts.asp?id=2131 (2016-02-14)
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  • Cell Research
    Deng 1 Jian Wu 1 Feng Wang 2 3 Junko Kanoh 4 Pierre Marie Dehe 5 Haruna Inoue 4 Juan Chen 1 and Ming Lei 1 2 3 1 National Center for Protein Science Shanghai State Key Laboratory of Molecular Biology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China 2 Howard Hughes Medical Institute Ann Arbor MI 48109 USA 3

    Original URL path: http://www.cell-research.com/arts.asp?id=2132 (2016-02-14)
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  • Cell Research
    the salt mine expands FREE Liliana E Lucca 1 and David A Hafler 1 1 Department of Neurology and Immunobiology Yale School of Medicine New Haven CT 06511 USA Correspondence David Hafler E mail david hafler yale edu High sodium consumption has been raising interest as a putative environmental factor linking Western lifestyle to the growing epidemic of autoimmune and inflammatory diseases Now Zhang and colleagues show that high sodium

    Original URL path: http://www.cell-research.com/arts.asp?id=2135 (2016-02-14)
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  • Cell Research
    degradation Furthermore the phospho deficient T205A FBW7 mutant is resistant to ERK activation and could significantly suppress pancreatic cancer cell proliferation and tumorigenesis These results collectively demonstrate how the oncogenic KRAS mutation inhibits the tumor suppressor FBW7 thus revealing an important function of KRAS mutations in promoting pancreatic cancer progression Three dimensional human facial morphologies as robust aging markers FREE Weiyang Chen 1 2 Wei Qian 1 2 Gang Wu 1 Weizhong Chen 1 2 Bo Xian 1 Xingwei Chen 1 2 Yaqiang Cao 1 2 Christopher D Green 1 Fanghong Zhao 3 Kun Tang 1 and Jing Dong J Han 1 4 10 1038 cr 2015 36 Full Text PDF Aging is associated with many complex diseases Reliable prediction of the aging process is important for assessing the risks of aging associated diseases However despite intense research so far there is no reliable aging marker Here we addressed this problem by examining whether human 3D facial imaging features could be used as reliable aging markers We collected 300 3D human facial images and blood profiles well distributed across ages of 17 to 77 years By analyzing the morphological profiles we generated the first comprehensive map of the aging human facial phenome We identified quantitative facial features such as eye slopes highly associated with age We constructed a robust age predictor and found that on average people of the same chronological age differ by 6 years in facial age with the deviations increasing after age 40 Using this predictor we identified slow and fast agers that are significantly supported by levels of health indicators Despite a close relationship between facial morphological features and health indicators in the blood facial features are more reliable aging biomarkers than blood profiles and can better reflect the general health status than chronological age Epigenetic silencing of microRNA 149 in cancer associated fibroblasts mediates prostaglandin E2 interleukin 6 signaling in the tumor microenvironment OPEN Pu Li 1 Jing Xuan Shan 3 Xue Hua Chen 1 Di Zhang 2 Li Ping Su 1 Xiu Ying Huang 2 Bei Qin Yu 1 Qiao Ming Zhi 1 Cheng Long Li 1 Ya Qing Wang 2 Sara Tomei 3 Qu Cai 1 Jun Ji 1 Jian Fang Li 1 Lotfi Chouchane 3 Ying Yan Yu 1 Fang Zhen Sun 2 Zhi Heng Xu 2 Bing Ya Liu 1 and Zheng Gang Zhu 1 10 1038 cr 2015 51 Full Text PDF Tumor initiation and growth depend on its microenvironment in which cancer associated fibroblasts CAFs in tumor stroma play an important role Prostaglandin E2 PGE2 and interleukin IL 6 signal pathways are involved in the crosstalk between tumor and stromal cells However how PGE2 mediated signaling modulates this crosstalk remains unclear Here we show that microRNA miR 149 links PGE2 and IL 6 signaling in mediating the crosstalk between tumor cells and CAFs in gastric cancer GC miR 149 inhibited fibroblast activation by targeting IL 6 and miR 149 expression was substantially suppressed in the CAFs of GC miR

    Original URL path: http://www.cell-research.com/artsmore.asp?id=183 (2016-02-14)
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  • Cell Research

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    Original URL path: /artsmore1.asp?id=184 (2016-02-14)


  • Cell Research
    1748 7838 2012 impact factor 10 526 Thomson Reuters 2013 Free Sample Issue Submission Advanced Online Publication Current Issue Top 10 VOLUME 25 ISSUE 6 6 2015 647 648 In cell infection bringing uninvited guests FREE Yongchan Lee 1 and Michael Overholtzer 1 1 Cell Biology Program Memorial Sloan Kettering Cancer Center New York NY 10065 USA Correspondence Michael Overholtzer E mail overhom1 mskcc org 10 1038 cr 2015 57

    Original URL path: http://www.cell-research.com/arts.asp?id=2109 (2016-02-14)
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  • Cell Research
    factor 10 526 Thomson Reuters 2013 Free Sample Issue Submission Advanced Online Publication Current Issue Top 10 VOLUME 25 ISSUE 6 6 2015 649 650 Cushing s disease towards precision medicine FREE Ursula B Kaiser 1 1 Division of Endocrinology Diabetes and Hypertension Brigham and Women s Hospital and Harvard Medical School 221 Longwood Avenue Boston MA 02115 USA Correspondence Ursula B Kaiser E mail ukaiser partners org 10 1038

    Original URL path: http://www.cell-research.com/arts.asp?id=2110 (2016-02-14)
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  • Cell Research
    Current Issue Top 10 VOLUME 25 ISSUE 6 6 2015 651 652 Shed NKG2D ligand boosts NK cell immunity FREE Emilie Narni Mancinelli 1 2 3 and Eric Vivier 1 2 3 4 1 Centre d Immunologie de Marseille Luminy UM2 Aix Marseille Université Marseille France 2 INSERM U1104 Marseille France 3 CNRS UMR7280 Marseille France 4 Service d Immunologie Assistance Publique Hôpitaux de Marseille Hôpital de la Conception Marseille

    Original URL path: http://www.cell-research.com/arts.asp?id=2111 (2016-02-14)
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