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  • Cell Research
    Ergin Beyret 1 and Juan Carlos Izpisua Belmonte 1 Lupus pathogenesis role of IgE autoantibodies FREE Jagadeesh Bayry 1 2 3 4 19 Jan 2016 RESEARCH HIGHLIGHTS SIRT6 oxidative stress and aging FREE Chen Yu Liao 1 and Brian K Kennedy 1 15 Jan 2016 LETTERS TO THE EDITOR Casilio a versatile CRISPR Cas9 Pumilio hybrid for gene regulation and genomic labeling OPEN Albert W Cheng 1 2 3 Nathaniel Jillette 1 2 Phoebe Lee 1 Dylan Plaskon 1 Yasuhiro Fujiwara 1 Wenbo Wang 1 Aziz Taghbalout 2 and Haoyi Wang 1 4 RESEARCH HIGHLIGHTS Master and commander epigenetic regulation of macrophages FREE Mihai G Netea 1 and Leo AB Joosten 1 Anti cancer effects of vitamin C revisited FREE Jiska van der Reest 1 and Eyal Gottlieb 1 ORIGINAL ARTICLES SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2 OPEN Huize Pan 1 Di Guan 1 Xiaomeng Liu 2 Jingyi Li 2 Lixia Wang 1 3 4 Jun Wu 5 Junzhi Zhou 1 Weizhou Zhang 6 Ruotong Ren 1 3 Weiqi Zhang 1 3 Ying Li 1 Jiping Yang 1 Ying Hao 3 4 Tingting Yuan 1 Guohong Yuan 1 Hu Wang 7 Zhenyu Ju 7 Zhiyong Mao 8 Jian Li 9 Jing Qu 4 Fuchou Tang 2 10 11 12 and Guang Hui Liu 1 3 12 13 Improved survival of porcine acute liver failure by a bioartificial liver device implanted with induced human functional hepatocytes OPEN Xiao Lei Shi 1 Yimeng Gao 2 Yupeng Yan 2 Hucheng Ma 1 Lulu Sun 2 Pengyu Huang 2 3 Xuan Ni 4 Ludi Zhang 2 Xin Zhao 1 Haozhen Ren 1 Dan Hu 5 Yan Zhou 5 Feng Tian 6 Yuan Ji 6 Xin Cheng 2 Guoyu Pan 4 Yi Tao Ding 1 and Lijian Hui 2 3 8 Jan 2016 ORIGINAL ARTICLES Pluripotency associated miR 290 302 family of microRNAs promote the dismantling of naive pluripotency OPEN Kai Li Gu 1 Qiang Zhang 1 Ying Yan 1 Ting Ting Li 2 Fei Fei Duan 1 Jing Hao 1 Xi Wen Wang 1 Ming Shi 1 Da Ren Wu 1 Wen Ting Guo 1 and Yangming Wang 1 5 Jan 2016 ORIGINAL ARTICLES The transcriptional regulator network of human inflammatory macrophages is defined by open chromatin OPEN Susanne V Schmidt 1 Wolfgang Krebs 1 Thomas Ulas 1 Jia Xue 1 Kevin Baßler 1 Patrick Günther 1 Anna Lena Hardt 1 Hartmut Schultze 2 Jil Sander 1 Kathrin Klee 1 Heidi Theis 1 Michael Kraut 1 Marc Beyer 1 and Joachim L Schultze 1 3 25 Dec 2015 ORIGINAL ARTICLES NudC regulates actin dynamics and ciliogenesis by stabilizing cofilin 1 Cheng Zhang 1 Wen Zhang 1 Yi Lu 1 Xiaoyi Yan 1 2 Xiumin Yan 3 Xueliang Zhu 3 Wei Liu 1 Yuehong Yang 1 2 and Tianhua Zhou 1 2 RESEARCH HIGHLIGHTS Organotropic metastasis role of tumor exosomes Yang Liu 1 and Xuetao Cao 1 22 Dec 2015 ORIGINAL ARTICLES Mutation of C elegans demethylase spr 5

    Original URL path: http://www.cell-research.com/aop.asp (2016-02-14)
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  • Cell Research
    IGF IR InsR as determined by assays on kinase dead IGF IR InsR mutants While both rictor and mTOR immunoprecitates from rictor MCF 10A cells exhibit tyrosine kinase activity towards IGF IR and InsR mTOR immunoprecipitates from rictor MCF 10A cells do not induce IGF IR and InsR phosphorylation Phosphorylation deficient mutation of residue Tyr1131 in IGF IR or Tyr1146 in InsR abrogates the activation of IGF IR InsR by mTOR Finally overexpression of rictor promotes IGF induced cell proliferation Our work identifies mTOR as a dual specificity kinase and clarifies how mTORC2 promotes IGF IR InsR activation Dicer independent RNA directed DNA methylation in Arabidopsis FREE Dong Lei Yang 1 3 Guiping Zhang 1 Kai Tang 2 Jingwen Li 1 Lan Yang 1 Huan Huang 1 Heng Zhang 1 and Jian Kang Zhu 1 2 10 1038 cr 2015 145 Full Text PDF RNA directed DNA methylation RdDM is an important de novo DNA methylation pathway in plants Small interfering RNAs siRNAs generated by Dicers from RNA polymerase IV Pol IV transcripts are thought to guide sequence specific DNA methylation To gain insight into the mechanism of RdDM we performed whole genome bisulfite sequencing of a collection of Arabidopsis mutants including plants deficient in Pol IV nrpd1 or Dicer dcl1 2 3 4 activity Unexpectedly of the RdDM target loci that required Pol IV and or Pol V only 16 were fully dependent on Dicer activity DNA methylation was partly or completely independent of Dicer activity at the remaining Pol IV and or Pol V dependent loci despite the loss of 24 nt siRNAs Instead DNA methylation levels correlated with the accumulation of Pol IV dependent 25 50 nt RNAs at most loci in Dicer mutant plants Our results suggest that RdDM in plants is largely guided by a previously unappreciated class of Dicer independent non coding RNAs and that siRNAs are required to maintain DNA methylation at only a subset of loci Somatosensory neuron types identified by high coverage single cell RNA sequencing and functional heterogeneity Chang Lin Li 1 Kai Cheng Li 1 Dan Wu 1 Yan Chen 1 Hao Luo 4 Jing Rong Zhao 1 Sa Shuang Wang 4 Ming Ming Sun 2 Ying Jin Lu 1 Yan Qing Zhong 1 Xu Ye Hu 5 Rui Hou 2 Bei Bei Zhou 2 Lan Bao 3 4 Hua Sheng Xiao 2 and Xu Zhang 1 4 10 1038 cr 2015 149 Full Text PDF Sensory neurons are distinguished by distinct signaling networks and receptive characteristics Thus sensory neuron types can be defined by linking transcriptome based neuron typing with the sensory phenotypes Here we classify somatosensory neurons of the mouse dorsal root ganglion DRG by high coverage single cell RNA sequencing 10 950 1 218 genes per neuron and neuron size based hierarchical clustering Moreover single DRG neurons responding to cutaneous stimuli are recorded using an in vivo whole cell patch clamp technique and classified by neuron type genetic markers Small diameter DRG neurons are classified into

    Original URL path: http://www.cell-research.com/artsmore.asp?id=193 (2016-02-14)
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  • Cell Research
    regulation of BRI1 signaling by BRI1 interacting protein BKI1 FREE Browse 5247 Ascorbic acid enhances the cardiac differentiation of induced pluripotent stem cells through promoting the proliferation of cardiac progenitor cells Browse 4919 ROS play a critical role in the differentiation of alternatively activated macrophages and the occurrence of tumor associated macrophages Browse 3961 Parkin mitochondrial translocation is achieved through a novel catalytic activity coupled mechanism Browse 3743 Structure of

    Original URL path: http://www.cell-research.com/reader.asp (2016-02-14)
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  • Cell Research
    USA 2 Herbert Irving Comprehensive Cancer Center New York NY 10065 USA 3 Cancer Biology and Genetics Program Memorial Sloan Kettering Cancer Center New York NY 10065 USA Correspondence Swarnali Acharyya E mail sa3141 cumc columbia edu Joan Massague E mail j massague ski mskcc org It is becoming increasingly clear that leukocytes dynamically regulate cancer progression and metastasis and among leukocytes granulocytic cells abundantly accumulate in metastatic organs however

    Original URL path: http://www.cell-research.com/aoparts.asp?id=466 (2016-02-14)
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  • Cell Research
    Yang 1 Su Yun Wang 1 Zhe Fu Huang 1 Hong Mei Zou 1 Bing Ru Yan 2 Wei Wei Luo 2 and Yan Yi Wang 1 1 Wuhan Institute of Virology State Key Laboratory of Virology Chinese Academy of Sciences Hubei 430071 China 2 Collaborative Innovation Center for Viral Immunology Medical Research Institute College of Life Sciences Wuhan University Hubei 430072 China Correspondence Yan Yi Wang Tel 86 27 87198095 Fax 86 27 87198095 E mail wangyy wh iov cn Recognition of viral dsRNA by Toll like receptor 3 TLR3 leads to induction of interferons IFNs and proinflammatory cytokines and innate antiviral response Here we identified the RNA binding protein Mex3B as a positive regulator of TLR3 mediated signaling by expression cloning screens Cells from Mex3b mice exhibited reduced production of IFN β in response to the dsRNA analog poly I C but not infection with RNA viruses Mex3b mice injected with poly I C was more resistant to poly I C induced death Mex3B was associated with TLR3 in the endosomes It bound to dsRNA and increased the dsRNA binding activity of TLR3 Mex3B also promoted the proteolytic processing of TLR3 which is critical for its activation Mutants

    Original URL path: http://www.cell-research.com/aoparts.asp?id=467 (2016-02-14)
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  • Cell Research
    Proud 1 1 Nutrition and Metabolism Theme South Australian Health Medical Research Institute North Terrace and University of Adelaide Adelaide Australia Correspondence Christopher G Proud E mail Christopher Proud sahmri com The mammalian target of rapamycin mTOR a protein kinase is the centre of huge attention due to its importance in intracellular signaling and in health and disease Nonetheless research in this area continues to generate surprise In their recent

    Original URL path: http://www.cell-research.com/arts.asp?id=2196 (2016-02-14)
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  • Cell Research
    W Pollard 1 2 1 MRC Centre for Reproductive Health Queen s Medical Research Institute The University of Edinburgh Edinburgh EH16 4TJ UK 2 Department of Developmental and Molecular Biology Albert Einstein College of Medicine New York NY 10461 USA Correspondence Jeffrey W Pollard E mail Jeff Pollard ed ac uk Classical inflammatory monocytes and their derivative macrophages promote tumor metastasis whereas CD8 T and NK cells restrict tumor growth

    Original URL path: http://www.cell-research.com/arts.asp?id=2197 (2016-02-14)
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  • Cell Research
    and Junjie Chen 3 1 School of Biomedical Sciences The University of Hong Kong Hong Kong SAR 2 State Key Laboratory of Brain and Cognitive Sciences The University of Hong Kong Hong Kong SAR 3 Department of Experimental Radiation Oncology The University of Texas MD Anderson Cancer Center 1515 Holcombe Boulevard Houston TX 77030 USA Correspondence jchen8 mdanderson org Adding to the Histone Code at DNA double strand breaks Mailand

    Original URL path: http://www.cell-research.com/arts.asp?id=2198 (2016-02-14)
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