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  • Cell Research
    stem cells efficiently support mouse generation by oocyte injection FREE Cuiqing Zhong 1 2 3 Zhenfei Xie 1 2 3 Qi Yin 1 2 3 Rui Dong 3 4 Suming Yang 1 2 3 Yuxuan Wu 1 2 Li Yang 4 and Jinsong Li 1 2 1 Group of Epigenetic Reprogramming State Key Laboratory of Cell Biology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China 2 Shanghai Key Laboratory of Molecular Andrology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China 3 University of Chinese Academy of Sciences Beijing 100049 China 4 Key Laboratory of Computational Biology CAS MPG Partner Institute for Computational Biology CAS Center for Excellence in Brain Science Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China Correspondence jsli sibcb ac cn Mammalian haploid embryonic stem cells haESCs have been recently generated from parthenogenetic and androgenetic embryos1 2 Both parthenogenetic haESCs PG haESCs and androgenetic haESCs AG haESCs can be used for cell based reverse and forward genetic screens on a whole genome scale3 4 AG haESCs after intracytoplasmic injection into oocytes referred to as

    Original URL path: http://www.cell-research.com/arts.asp?id=2207 (2016-02-14)
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  • Cell Research
    Yukai Wang 1 Xiu Jie Wang 3 Wei Li 1 Qi Zhou 1 and Baoyang Hu 1 1 State Key Laboratory of Stem cell and Reproductive Biology Institute of Zoology Chinese Academy of Sciences Beijing 100101 China 2 University of Chinese Academy of Sciences Beijing 100049 China 3 Key Laboratory of Genetic Network Biology Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 China 4 College of Life Science Northeast Agricultural University of China Harbin Heilongjiang 150030 China Correspondence Baoyang Hu E mail byhu ioz ac cn Qi Zhou E mail qzhou ioz ac cn Wei Li E mail liwei ioz ac cn Normal mammalian development requires participation of both maternal and paternal genomes because of the existence of genomic imprinting whereas the gynogenetic and androgenetic embryos die shortly after implantation1 2 3 Generation of gynogenetic bimaternal mice containing two sets of maternal genomes was achieved using non growing oocytes with imprinting modifications4 however the approach was technically challenging and impractical for further applications Recently we and others have derived mammalian androgenetic and parthenogenetic haploid embryonic stem cells ahESCs and phESCs and showed that ahESCs can replace gametes to produce offspring5 6 7 which provided alternative resources

    Original URL path: http://www.cell-research.com/arts.asp?id=2208 (2016-02-14)
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  • Cell Research
    juvenile monkey testicular xenografts FREE Zhen Liu 1 Yan Hong Nie 1 Chen Chen Zhang 1 Yi Jun Cai 1 Yan Wang 1 Hui Ping Lu 1 Yu Zhuo Li 1 Cheng Cheng 1 Zi Long Qiu 1 and Qiang Sun 1 1 Institute of Neuroscience Key Laboratory of Primate Neurobiology CAS Center for Excellence in Brain Science Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China Correspondence Qiang Sun E mail qsun ion ac cn Germ cell transplantation and testicular tissue grafting have been developed for male fertility restoration1 The testis tissue from young mammals including mice and monkeys is capable of undergoing complete spermatogenesis in xenografts and sperms obtained from monkey testicular tissue xenografts have yielded monkey blastocysts after intracytoplasmic sperm injection ICSI although no successful production of primates has been reported2 3 4 Achieving the latter is important because of its potential implication for restoring fertility of young cancer patients undergoing radiotherapy and chemotherapy In this study we generated monkey offspring using sperm derived from testicular tissue xenografts of juvenile wild type WT and transgenic cynomolgus monkeys macaca fascicularis Our results demonstrate that the testis xenografting approach could shorten the generation of cynomolgus monkey

    Original URL path: http://www.cell-research.com/arts.asp?id=2209 (2016-02-14)
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  • 6 5 4 3 2 1

    Original URL path: http://www.cell-research.com/pic_2.html (2016-02-14)
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  • Jan 2016 About the cover Volume 25 No 12 Dec 2015 About the cover Volume 25 No 11 Nov 2015 About the cover Volume 25 No 10 Oct 2015 About

    Original URL path: http://www.cell-research.com/pic.asp (2016-02-14)
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  • 1

    Original URL path: http://www.cell-research.com/right_gg.html (2016-02-14)
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  • Cell Research
    into the mechanism of YAP TAZ target genes in cell growth regulation MSX2 mediates entry of human pluripotent stem cells into mesendoderm by simultaneously suppressing SOX2 and activating NODAL signaling FREE Qingqing Wu 1 2 Leisheng Zhang 1 2 Pei Su 1 2 Xiaohua Lei 3 Xin Liu 1 2 Hongtao Wang 1 2 Lisha Lu 4 Yang Bai 1 2 Tao Xiong 4 Dong Li 5 Zhengmao Zhu 6 Enkui Duan 3 Erlie Jiang 1 2 Sizhou Feng 1 2 Mingzhe Han 1 2 Yuanfu Xu 1 2 Fei Wang 7 and Jiaxi Zhou 1 2 10 1038 cr 2015 118 Full Text PDF How BMP signaling integrates into and destabilizes the pluripotency circuitry of human pluripotent stem cells hPSCs to initiate differentiation into individual germ layers is a long standing puzzle Here we report muscle segment homeobox 2 MSX2 a homeobox transcription factor of msh family as a direct target gene of BMP signaling and a master mediator of hPSCs differentiation to mesendoderm Enforced expression of MSX2 suffices to abolish pluripotency and induce directed mesendoderm differentiation of hPSCs while MSX2 depletion impairs mesendoderm induction MSX2 is a direct target gene of the BMP pathway in hPSCs and can be synergistically activated by Wnt signals via LEF1 during mesendoderm induction Furthermore MSX2 destabilizes the pluripotency circuitry through direct binding to the SOX2 promoter and repression of SOX2 transcription while MSX2 controls mesendoderm lineage commitment by simultaneous suppression of SOX2 and induction of NODAL expression through direct binding and activation of the Nodal promoter Interestingly SOX2 can promote the degradation of MSX2 protein suggesting a mutual antagonism between the two lineage specifying factors in the control of stem cell fate Together our findings reveal crucial new mechanisms of destabilizing pluripotency and directing lineage commitment in hPSCs Tuberculosis is associated with expansion of a motile permissive and immunomodulatory CD16 monocyte population via the IL 10 STAT3 axis FREE Claire Lastrucci 1 2 Alan Bénard 1 2 Luciana Balboa 3 Karine Pingris 1 2 Shanti Souriant 1 2 Renaud Poincloux 1 2 Talal Al Saati 4 Voahangy Rasolofo 5 Pablo González Montaner 6 Sandra Inwentarz 6 Eduardo Jose Moraña 6 Ivanela Kondova 7 Frank AW Verreck 7 Maria del Carmen Sasiain 3 Olivier Neyrolles 1 2 Isabelle Maridonneau Parini 1 2 Geanncarlo Lugo Villarino 1 2 and Céline Cougoule 1 2 10 1038 cr 2015 123 Full Text PDF The human CD14 monocyte compartment is composed by two subsets based on CD16 expression We previously reported that this compartment is perturbed in tuberculosis TB patients as reflected by the expansion of CD16 monocytes along with disease severity Whether this unbalance is beneficial or detrimental to host defense remains to be elucidated Here in the context of active TB we demonstrate that human monocytes are predisposed to differentiate towards an anti inflammatory M2 like macrophage activation program characterized by the CD16 CD163 MerTK pSTAT3 phenotype and functional properties such as enhanced protease dependent motility pathogen permissivity and immunomodulation This process is dependent on

    Original URL path: http://www.cell-research.com/artsmore.asp?id=191 (2016-02-14)
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  • Cell Research
    signals Since we found that ASXL1 and BAP1 both are enriched at the INK4B locus our results suggest that activation of the INK4B locus requires ASXL1 BAP1 mediated deubiquitinylation of H2AK119ub1 Consistently our results show that ASXL1 mutations are associated with lower expression levels of p15INK4B and a proliferative advantage of hematopoietic progenitors in primary bone marrow cells and that depletion of ASXL1 in multiple cell lines results in resistance to growth inhibitory signals Taken together this study links ASXL1 mediated H2A deubiquitinylation and transcriptional activation of INK4B expression to its tumor suppressor functions Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3 ligase signaling effector DWARF3 FREE Li Hua Zhao1 2 X Edward Zhou3 Wei Yi1 Zhongshan Wu1 3 4 Yue Liu1 Yanyong Kang3 Li Hou1 3 Parker W de Waal3 Suling Li1 Yi Jiang1 Adrian Scaffidi5 Gavin R Flematti5 Steven M Smith5 6 7 Vinh Q Lam8 Patrick R Griffin8 Yonghong Wang7 Jiayang Li7 Karsten Melcher1 3 and H Eric Xu1 3 10 1038 cr 2015 122 Full Text PDF Strigolactones SLs are endogenous hormones and exuded signaling molecules in plant responses to low levels of mineral nutrients Key mediators of the SL signaling pathway in rice include the α β fold hydrolase DWARF 14 D14 and the F box component DWARF 3 D3 of the ubiquitin ligase SCFD3 that mediate ligand dependent degradation of downstream signaling repressors One perplexing feature is that D14 not only functions as the SL receptor but is also an active enzyme that slowly hydrolyzes diverse natural and synthetic SLs including GR24 preventing the crystallization of a binary complex of D14 with an intact SL as well as the ternary D14 SL D3 complex Here we overcome these barriers to derive a structural model of D14 bound to intact GR24 and identify the interface that is required for GR24 mediated D14 D3 interaction The mode of GR24 mediated signaling including ligand recognition hydrolysis by D14 and ligand mediated D14 D3 interaction is conserved in structurally diverse SLs More importantly D14 is destabilized upon the binding of ligands and D3 thus revealing an unusual mechanism of SL recognition and signaling in which the hormone the receptor and the downstream effectors are systematically destabilized during the signal transduction process A humanized neutralizing antibody against MERS CoV targeting the receptor binding domain of the spike protein FREE Yan Li 1 Yuhua Wan 1 2 3 Peipei Liu 1 Jincun Zhao 4 11 Guangwen Lu 5 Jianxun Qi 1 Qihui Wang 3 Xuancheng Lu 6 Ying Wu 1 Wenjun Liu 1 Buchang Zhang 2 Kwok Yung Yuen 7 Stanley Perlman 4 George F Gao 1 2 8 9 10 and Jinghua Yan 1 2 3 10 1038 cr 2015 113 Full Text PDF The newly emerging Middle East respiratory syndrome coronavirus MERS CoV can cause severe and fatal acute respiratory disease in humans Despite global efforts the potential for an associated pandemic in the future cannot be excluded The development of effective counter measures is

    Original URL path: http://www.cell-research.com/artsmore.asp?id=190 (2016-02-14)
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