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  • Cell Research

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    Original URL path: /artsmore1.asp?id=8 (2016-02-14)



  • Cell Research
    Correspondence Nabeel Bardeesy E mail bardeesy nabeel mgh harvard edu The LKB1 tumor suppressor encodes a serine threonine kinase whose substrates control cell metabolism polarity and motility LKB1 is a major mediator of the cellular response to energy stress via activation of the master regulator of energy homeostasis AMPK While mutational inactivation of LKB1 promotes the development of many types of epithelial cancer a recent report in Nature by Jeon

    Original URL path: http://www.cell-research.com/arts.asp?id=66 (2016-02-14)
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  • Cell Research
    1623 Taking a bite out of Wnts Cortney M Bouldin and David Kimelman Department of Biochemistry University of Washington Seattle WA 98103 7350 USA Correspondence David Kimelman E mail kimelman uw edu Proper control of intercellular communication through the Wnt signaling pathway is of critical importance for many aspects of biology including head formation during vertebrate embryogenesis A recent Cell paper describes the discovery of a novel protein TIKI which

    Original URL path: http://www.cell-research.com/arts.asp?id=67 (2016-02-14)
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  • Cell Research
    of mammalian recombination Kenneth Paigen and Petko Petkov The Jackson Laboratory Bar Harbor ME 04609 USA Correspondence Kenneth Paigen E mail ken paigen jax org The laboratories of Galina Petukhova and R Daniel Camerini Otero have achieved significant technical advances in determining the genome wide sites of DNA double strand breaks DSBs where the process of genetic exchange between chromatids during meiosis begins Applying the new approaches to male meiosis

    Original URL path: http://www.cell-research.com/arts.asp?id=68 (2016-02-14)
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  • Cell Research
    Online Publication Current Issue Top 10 VOLUME 22 ISSUE 12 12 2012 1627 1630 Huntington s disease Dancing in a dish Kejing Zhang 1 Fei Yi 1 Guang Hui Liu 1 2 and Juan Carlos Izpisua Belmonte 1 3 1 Gene Expression Laboratory Salk Institute for Biological Studies 10010 North Torrey Pines Road La Jolla CA 92037 USA 2 National Laboratory of Biomacromolecules Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China 3 Center for Regenerative Medicine in Barcelona Dr Aiguader 88 08003 Barcelona Spain Correspondence Guang Hui Liu Juan Carlos Izpisua Belmonte E mail ghliu ibp ac cn belmonte salk edu izpisua cmrb eu In a recent landmark paper the Huntington s disease HD iPSC Consortium reports on the establishment and characterization of a panel of iPSC lines from HD patients and more importantly the successful modeling of HD in vitro In the same issue of Cell Stem Cell An et al reports on the successful targeted gene correction of HD in human iPSCs Both advances are exciting provide new resources for current and future HD research and uncover new challenges to better understand and most importantly treat this devastating disease in the near future Cell Research 2012

    Original URL path: http://www.cell-research.com/arts.asp?id=69 (2016-02-14)
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  • Cell Research
    Plant Research Ithaca NY 14853 USA Correspondence Daniel F Klessig E mail dfk8 cornell edu Salicylic acid SA is widely recognized as a key player in plant immunity While several proteins have been previously identified as the direct targets of SA SA mediated plant defense signaling mechanisms remain unclear The Nature paper from Xinnian Dong s group demonstrates that the NPR1 paralogues NPR3 and NPR4 directly bind SA and this

    Original URL path: http://www.cell-research.com/arts.asp?id=70 (2016-02-14)
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  • Cell Research
    Gene Regulation Stem Cells and Cancer Programme Centre for Genomic Regulation CRG UPF Dr Aiguader 88 08003 Barcelona Spain Correspondence Fátima Gebauer Tel 34 93 3160120 E mail fatima gebauer crg eu Cap dependent translation is initiated by the binding of eIF4E to the cap structure at the 5 end of mRNAs During hypoxic stress global translation decreases because eIF4E is inactivated In a recent article in Nature Lee and

    Original URL path: http://www.cell-research.com/arts.asp?id=71 (2016-02-14)
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  • Cell Research
    2013 Free Sample Issue Submission Advanced Online Publication Current Issue Top 10 VOLUME 22 ISSUE 12 12 2012 1637 1639 Mechanisms involved in the Abacavir mediated hypersensitivity syndrome Anuska Llano 1 and Christian Brander 1 2 3 1 Irsicaixa AIDS Research Institute HIVACAT Hospital Universitari Germans Trias i Pujol Badalona Spain 2 Universitat Aut騨oma de Barcelona Hospital Universitari Germans Trias i Pujol Badalona Spain 3 Instituci Catalana de Reserca i Estudis Avan鏰ts ICREA Barcelona Spain Correspondence Christian Brander Tel 34 93 465 63 E mail cbrander irsicaixa es The potentially life threatening adverse reactions to Abavacir ABC a nucleoside analog reverse transcriptase inhibitor for the treatment of HIV infection have been known for several years to be limited to individuals expressing the HLA B 57 01 gene Why the ABC hypersensitivity syndrome is only seen in HLA B 57 01 expressing subjects and what the precise mechanisms underlying this intolerance are remain however controversial A series of recent studies particularly a study by Illing et al recently published in Nature now answer some of these questions and offer new opportunities to better understand autoimmune disorders and prevent adverse reactions to other drugs Cell Research 2012 22 1637 1639 doi 10

    Original URL path: http://www.cell-research.com/arts.asp?id=72 (2016-02-14)
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